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Preconceptional Iron Intake and Gestational Diabetes Mellitus.
Int J Environ Res Public Health. 2016 05 24; 13(6)IJ

Abstract

Our objective was to assess the impact of preconceptional heme and non-heme iron on gestational diabetes mellitius (GDM) in the Boston University Slone Epidemiology Birth Defects Study (BDS). This retrospective cohort analysis included 7229 participants enrolled in the BDS between 1998 and 2008 who gave birth to non-malformed infants and were free of pre-existing diabetes. All data were collected through structured interviews conducted within 6 months of delivery. Calorie-adjusted and multivariable odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. Preconceptional dietary heme iron was modestly associated with an elevated risk of GDM among those (multivariable OR comparing the fifth quintile to the first: 1.55; 95% CI 0.98, 2.46). Conversely, preconceptional dietary non-heme iron was associated with a decreased risk of GDM among those in the fifth quintile of intake compared to the first (multivariable OR: 0.48; 95% CI 0.28, 0.81). Women who consumed supplemental iron during preconception also had a decreased risk of GDM (multivariable OR: 0.78; 95% CI 0.60, 1.02). In conclusion, our data support a positive association between preconceptional heme iron intake and GDM and an inverse association between preconceptional non-heme iron intake from foods and preconceptional intake from supplements.

Authors+Show Affiliations

Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA. amdarlin@bu.edu.Slone Epidemiology Center at Boston University, Boston, MA 02215, USA. allenmit@bu.edu.Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA. werler@bu.edu. Slone Epidemiology Center at Boston University, Boston, MA 02215, USA. werler@bu.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27231921

Citation

Darling, Anne Marie, et al. "Preconceptional Iron Intake and Gestational Diabetes Mellitus." International Journal of Environmental Research and Public Health, vol. 13, no. 6, 2016.
Darling AM, Mitchell AA, Werler MM. Preconceptional Iron Intake and Gestational Diabetes Mellitus. Int J Environ Res Public Health. 2016;13(6).
Darling, A. M., Mitchell, A. A., & Werler, M. M. (2016). Preconceptional Iron Intake and Gestational Diabetes Mellitus. International Journal of Environmental Research and Public Health, 13(6). https://doi.org/10.3390/ijerph13060525
Darling AM, Mitchell AA, Werler MM. Preconceptional Iron Intake and Gestational Diabetes Mellitus. Int J Environ Res Public Health. 2016 05 24;13(6) PubMed PMID: 27231921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preconceptional Iron Intake and Gestational Diabetes Mellitus. AU - Darling,Anne Marie, AU - Mitchell,Allen A, AU - Werler,Martha M, Y1 - 2016/05/24/ PY - 2016/03/15/received PY - 2016/05/09/revised PY - 2016/05/16/accepted PY - 2016/5/28/entrez PY - 2016/5/28/pubmed PY - 2017/7/25/medline KW - diet KW - gestational diabetes KW - iron KW - pregnancy JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 13 IS - 6 N2 - Our objective was to assess the impact of preconceptional heme and non-heme iron on gestational diabetes mellitius (GDM) in the Boston University Slone Epidemiology Birth Defects Study (BDS). This retrospective cohort analysis included 7229 participants enrolled in the BDS between 1998 and 2008 who gave birth to non-malformed infants and were free of pre-existing diabetes. All data were collected through structured interviews conducted within 6 months of delivery. Calorie-adjusted and multivariable odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. Preconceptional dietary heme iron was modestly associated with an elevated risk of GDM among those (multivariable OR comparing the fifth quintile to the first: 1.55; 95% CI 0.98, 2.46). Conversely, preconceptional dietary non-heme iron was associated with a decreased risk of GDM among those in the fifth quintile of intake compared to the first (multivariable OR: 0.48; 95% CI 0.28, 0.81). Women who consumed supplemental iron during preconception also had a decreased risk of GDM (multivariable OR: 0.78; 95% CI 0.60, 1.02). In conclusion, our data support a positive association between preconceptional heme iron intake and GDM and an inverse association between preconceptional non-heme iron intake from foods and preconceptional intake from supplements. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/27231921/Preconceptional_Iron_Intake_and_Gestational_Diabetes_Mellitus_ L2 - https://www.mdpi.com/resolver?pii=ijerph13060525 DB - PRIME DP - Unbound Medicine ER -