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Prenatal phthalate exposure and infant size at birth and gestational duration.
Environ Res. 2016 10; 150:52-58.ER

Abstract

BACKGROUND

Phthalate exposure is widespread. Prior research suggests that prenatal phthalate exposure may influence birth size and gestational duration, but published results have been inconsistent.

OBJECTIVE

We quantified the relationship between maternal urinary phthalate concentrations and infant birth weight z-scores, length, head circumference, and gestational duration.

METHODS

In a cohort of 368 women from the HOME Study, based in Cincinnati, OH, we measured nine phthalate metabolites representing exposure to six parent phthalate diesters in urine collected at approximately 16 and 26 weeks gestation. Infant birth size and gestational duration were abstracted from medical records. We used multivariable linear regression to estimate covariate adjusted associations between urinary phthalate metabolite concentrations and infant outcomes.

RESULTS

In unadjusted models, we observed a negative association between monoethyl phthalate (MEP) and birth weight z-scores, while mono-3-carboxypropyl phthalate (MCPP) was positively associated with gestational duration. After covariate adjustment, phthalate metabolite concentrations were no longer associated with birth size or gestational duration.

CONCLUSIONS

In this cohort, urinary phthalate metabolite concentrations during pregnancy were not associated with infant birth size or gestational duration. Additional research is needed to determine if exposures during earlier periods of fetal development are associated with infant health.

Authors+Show Affiliations

Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.Cincinnati Children's Hospital Medical Center, Department of Pediatrics, Cincinnati, OH, USA.Faculty of Health and Sciences, Simon Fraser University, Burnaby, Canada; Child and Family Research Institute, BC Children's and Women's Hospital, Vancouver, Canada.Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA, USA.Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. Electronic address: joseph_braun_1@brown.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27236572

Citation

Shoaff, Jessica R., et al. "Prenatal Phthalate Exposure and Infant Size at Birth and Gestational Duration." Environmental Research, vol. 150, 2016, pp. 52-58.
Shoaff JR, Romano ME, Yolton K, et al. Prenatal phthalate exposure and infant size at birth and gestational duration. Environ Res. 2016;150:52-58.
Shoaff, J. R., Romano, M. E., Yolton, K., Lanphear, B. P., Calafat, A. M., & Braun, J. M. (2016). Prenatal phthalate exposure and infant size at birth and gestational duration. Environmental Research, 150, 52-58. https://doi.org/10.1016/j.envres.2016.05.033
Shoaff JR, et al. Prenatal Phthalate Exposure and Infant Size at Birth and Gestational Duration. Environ Res. 2016;150:52-58. PubMed PMID: 27236572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal phthalate exposure and infant size at birth and gestational duration. AU - Shoaff,Jessica R, AU - Romano,Megan E, AU - Yolton,Kimberly, AU - Lanphear,Bruce P, AU - Calafat,Antonia M, AU - Braun,Joseph M, Y1 - 2016/05/26/ PY - 2016/02/22/received PY - 2016/05/17/revised PY - 2016/05/18/accepted PY - 2016/5/30/entrez PY - 2016/5/30/pubmed PY - 2017/5/2/medline KW - Birth outcomes KW - Endocrine disrupting chemicals KW - Exposure KW - Phthalate KW - Prenatal SP - 52 EP - 58 JF - Environmental research JO - Environ Res VL - 150 N2 - BACKGROUND: Phthalate exposure is widespread. Prior research suggests that prenatal phthalate exposure may influence birth size and gestational duration, but published results have been inconsistent. OBJECTIVE: We quantified the relationship between maternal urinary phthalate concentrations and infant birth weight z-scores, length, head circumference, and gestational duration. METHODS: In a cohort of 368 women from the HOME Study, based in Cincinnati, OH, we measured nine phthalate metabolites representing exposure to six parent phthalate diesters in urine collected at approximately 16 and 26 weeks gestation. Infant birth size and gestational duration were abstracted from medical records. We used multivariable linear regression to estimate covariate adjusted associations between urinary phthalate metabolite concentrations and infant outcomes. RESULTS: In unadjusted models, we observed a negative association between monoethyl phthalate (MEP) and birth weight z-scores, while mono-3-carboxypropyl phthalate (MCPP) was positively associated with gestational duration. After covariate adjustment, phthalate metabolite concentrations were no longer associated with birth size or gestational duration. CONCLUSIONS: In this cohort, urinary phthalate metabolite concentrations during pregnancy were not associated with infant birth size or gestational duration. Additional research is needed to determine if exposures during earlier periods of fetal development are associated with infant health. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/27236572/Prenatal_phthalate_exposure_and_infant_size_at_birth_and_gestational_duration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(16)30205-5 DB - PRIME DP - Unbound Medicine ER -