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Apolipoprotein E gene polymorphism and the risk of subarachnoid hemorrhage: a meta-analysis of case-control studies.
Acta Neurochir (Wien). 2016 08; 158(8):1515-22.AN

Abstract

BACKGROUND

Studies investigating the association between the apolipoprotein E gene (APOE) polymorphism and the risk of subarachnoid hemorrhage (SAH) have reported inconsistent results. So we performed a meta-analysis to estimate the association between APOE polymorphism and SAH susceptibility.

METHODS

Relevant studies published before 5 November 2015 were identified by searching PubMed, Embase, EBSCO, and ISI web of knowledge. The strength of relationship between the APOE gene and SAH susceptibility was assessed using odds ratio (OR) and corresponding 95 % confidence interval (95 % CI).

RESULTS

A total number of six case-control studies including 638 SAH cases and 2,341 controls were identified. No association was found in dominant model or allele contrast genetic model (ε4 dominant model: OR = 1.06, 95 % CI = 0.91-1.25; ε3 dominant model: OR = 0.99, 95 % CI = 0.97-1.01; ε2 dominant model: OR = 0.99, 95 % CI = 0.78-1.25; ε4 versus ε3: OR = 1.14, 95 % CI = 0.96-1.35; ε4 versus ε2: OR = 1.07, 95 % CI = 0.90-1.28; ε3 versus ε2: OR = 1.00, 95 % CI = 0.96-1.04) for APOE polymorphism and SAH susceptibility. In the subgroup analyzed that was stratified by ethnicity, increased risk of SAH was found in Asian subjects when ε4 allele compared with ε3 allele (ε4 vs ε3, OR = 1.55, 95 % CI = 1.07-2.52).

CONCLUSIONS

Our meta-analysis suggested that there is no association between APOE polymorphism and SAH risk for overall population. Due to several limitations in the present study, well-designed epidemiological studies with large sample size among different ethnicities should be performed in the future.

Authors+Show Affiliations

Department of Neurosurgery, The First Hospital of Hebei Medical University, Shijiazhuang, China.Department of Neurosurgery, Affiliated Bayi Brain Hospital, Military General Hospital of Beijing PLA, Beijing, China.Department of Neurosurgery, The First Hospital of Hebei Medical University, Shijiazhuang, China.Department of Neurosurgery, Tangshan Gongren Hospital, Tangshan City, China.Centralized Procurement Center for Medical Instruments of Hebei, Shijiazhuang, China.Department of TCM Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.Hebei Medical University, Shijiazhuang, China.Department of Neurosurgery, The Second Hospital of Hebei Medical University, No. 215 West Heping Road, Shijiazhuang, 050005, China.Hebei Medical Science and Technology Development Research Center, Shijiazhuang, China.Institute of Medical Information of Hebei, Shijiazhuang, China.Department of Neurosurgery, The Second Hospital of Hebei Medical University, No. 215 West Heping Road, Shijiazhuang, 050005, China. songjianok@tom.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

27241684

Citation

Zhao, Di, et al. "Apolipoprotein E Gene Polymorphism and the Risk of Subarachnoid Hemorrhage: a Meta-analysis of Case-control Studies." Acta Neurochirurgica, vol. 158, no. 8, 2016, pp. 1515-22.
Zhao D, Zhang Z, Wu GB, et al. Apolipoprotein E gene polymorphism and the risk of subarachnoid hemorrhage: a meta-analysis of case-control studies. Acta Neurochir (Wien). 2016;158(8):1515-22.
Zhao, D., Zhang, Z., Wu, G. B., Wang, H. Y., Gao, F., Duan, X. D., Lu, Y. Y., Wang, Z. M., You, D. P., Qu, Y., & Song, J. (2016). Apolipoprotein E gene polymorphism and the risk of subarachnoid hemorrhage: a meta-analysis of case-control studies. Acta Neurochirurgica, 158(8), 1515-22. https://doi.org/10.1007/s00701-016-2824-2
Zhao D, et al. Apolipoprotein E Gene Polymorphism and the Risk of Subarachnoid Hemorrhage: a Meta-analysis of Case-control Studies. Acta Neurochir (Wien). 2016;158(8):1515-22. PubMed PMID: 27241684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E gene polymorphism and the risk of subarachnoid hemorrhage: a meta-analysis of case-control studies. AU - Zhao,Di, AU - Zhang,Zhenhai, AU - Wu,Guo-Biao, AU - Wang,Hong-Yu, AU - Gao,Fei, AU - Duan,Xu-Dong, AU - Lu,Ying-Ying, AU - Wang,Zhi-Ming, AU - You,Dian-Ping, AU - Qu,Yi, AU - Song,Jian, Y1 - 2016/05/30/ PY - 2015/12/24/received PY - 2016/04/25/accepted PY - 2016/6/1/entrez PY - 2016/6/1/pubmed PY - 2017/9/9/medline KW - Apolipoprotein E KW - Gene polymorphism KW - Meta-analysis KW - Subarachnoid hemorrhage SP - 1515 EP - 22 JF - Acta neurochirurgica JO - Acta Neurochir (Wien) VL - 158 IS - 8 N2 - BACKGROUND: Studies investigating the association between the apolipoprotein E gene (APOE) polymorphism and the risk of subarachnoid hemorrhage (SAH) have reported inconsistent results. So we performed a meta-analysis to estimate the association between APOE polymorphism and SAH susceptibility. METHODS: Relevant studies published before 5 November 2015 were identified by searching PubMed, Embase, EBSCO, and ISI web of knowledge. The strength of relationship between the APOE gene and SAH susceptibility was assessed using odds ratio (OR) and corresponding 95 % confidence interval (95 % CI). RESULTS: A total number of six case-control studies including 638 SAH cases and 2,341 controls were identified. No association was found in dominant model or allele contrast genetic model (ε4 dominant model: OR = 1.06, 95 % CI = 0.91-1.25; ε3 dominant model: OR = 0.99, 95 % CI = 0.97-1.01; ε2 dominant model: OR = 0.99, 95 % CI = 0.78-1.25; ε4 versus ε3: OR = 1.14, 95 % CI = 0.96-1.35; ε4 versus ε2: OR = 1.07, 95 % CI = 0.90-1.28; ε3 versus ε2: OR = 1.00, 95 % CI = 0.96-1.04) for APOE polymorphism and SAH susceptibility. In the subgroup analyzed that was stratified by ethnicity, increased risk of SAH was found in Asian subjects when ε4 allele compared with ε3 allele (ε4 vs ε3, OR = 1.55, 95 % CI = 1.07-2.52). CONCLUSIONS: Our meta-analysis suggested that there is no association between APOE polymorphism and SAH risk for overall population. Due to several limitations in the present study, well-designed epidemiological studies with large sample size among different ethnicities should be performed in the future. SN - 0942-0940 UR - https://www.unboundmedicine.com/medline/citation/27241684/Apolipoprotein_E_gene_polymorphism_and_the_risk_of_subarachnoid_hemorrhage:_a_meta_analysis_of_case_control_studies_ L2 - https://dx.doi.org/10.1007/s00701-016-2824-2 DB - PRIME DP - Unbound Medicine ER -