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Pulmonary manifestations of Sjögren's syndrome.
Eur Respir Rev. 2016 Jun; 25(140):110-23.ER

Abstract

In 9-20% of cases, Sjögren's syndrome is associated with various respiratory symptoms. The most typical manifestations are chronic interstitial lung disease (ILD) and tracheobronchial disease. The most common manifestation of ILD is nonspecific interstitial pneumonia in its fibrosing variant. Other types of ILD, such as organising pneumonia, usual interstitial pneumonia and lymphocytic interstitial pneumonitis, are rare. Their radiological presentation is less distinctive, and definitive diagnosis may require the use of transbronchial or surgical lung biopsy. Corticosteroid therapy is the mainstay of ILD treatment in Sjögren's syndrome, but the use of other immunosuppressive drugs needs to be determined. ILD is a significant cause of death in Sjögren's syndrome. Tracheobronchial disease is common in Sjögren's syndrome, characterised by diffuse lymphocytic infiltration of the airway. It is sometimes responsible for a crippling chronic cough. It can also present in the form of bronchial hyperresponsiveness, bronchiectasis, bronchiolitis or recurrent respiratory infections. The management of these manifestations may require treatment for dryness and/or inflammation of the airways. Airway disease has little effect on respiratory function and is rarely the cause of death in Sjögren's syndrome patients. Rare respiratory complications such as amyloidosis, lymphoma or pulmonary hypertension should not be disregarded in Sjögren's syndrome patients.

Authors+Show Affiliations

Service de Pneumologie, CHRU Tours, Tours, France.Service de Médecine Interne, CHRU Tours, Tours, France.Service de Médecine Interne, CHRU Tours, Tours, France.Service de Pneumologie, CHRU Tours, Tours, France Service de Médecine Interne, CHRU Tours, Tours, France Université François Rabelais, UMR 1100, Tours, France INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100/EA6305, Tours, France.Service de Médecine Interne, CHRU Tours, Tours, France.Service de Pneumologie, CHRU Tours, Tours, France Université François Rabelais, UMR 1100, Tours, France INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100/EA6305, Tours, France s.marchandadam@univ-tours.fr.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27246587

Citation

Flament, Thomas, et al. "Pulmonary Manifestations of Sjögren's Syndrome." European Respiratory Review : an Official Journal of the European Respiratory Society, vol. 25, no. 140, 2016, pp. 110-23.
Flament T, Bigot A, Chaigne B, et al. Pulmonary manifestations of Sjögren's syndrome. Eur Respir Rev. 2016;25(140):110-23.
Flament, T., Bigot, A., Chaigne, B., Henique, H., Diot, E., & Marchand-Adam, S. (2016). Pulmonary manifestations of Sjögren's syndrome. European Respiratory Review : an Official Journal of the European Respiratory Society, 25(140), 110-23. https://doi.org/10.1183/16000617.0011-2016
Flament T, et al. Pulmonary Manifestations of Sjögren's Syndrome. Eur Respir Rev. 2016;25(140):110-23. PubMed PMID: 27246587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulmonary manifestations of Sjögren's syndrome. AU - Flament,Thomas, AU - Bigot,Adrien, AU - Chaigne,Benjamin, AU - Henique,Helene, AU - Diot,Elisabeth, AU - Marchand-Adam,Sylvain, PY - 2016/02/23/received PY - 2016/04/02/accepted PY - 2016/6/2/entrez PY - 2016/6/2/pubmed PY - 2017/4/13/medline SP - 110 EP - 23 JF - European respiratory review : an official journal of the European Respiratory Society JO - Eur Respir Rev VL - 25 IS - 140 N2 - In 9-20% of cases, Sjögren's syndrome is associated with various respiratory symptoms. The most typical manifestations are chronic interstitial lung disease (ILD) and tracheobronchial disease. The most common manifestation of ILD is nonspecific interstitial pneumonia in its fibrosing variant. Other types of ILD, such as organising pneumonia, usual interstitial pneumonia and lymphocytic interstitial pneumonitis, are rare. Their radiological presentation is less distinctive, and definitive diagnosis may require the use of transbronchial or surgical lung biopsy. Corticosteroid therapy is the mainstay of ILD treatment in Sjögren's syndrome, but the use of other immunosuppressive drugs needs to be determined. ILD is a significant cause of death in Sjögren's syndrome. Tracheobronchial disease is common in Sjögren's syndrome, characterised by diffuse lymphocytic infiltration of the airway. It is sometimes responsible for a crippling chronic cough. It can also present in the form of bronchial hyperresponsiveness, bronchiectasis, bronchiolitis or recurrent respiratory infections. The management of these manifestations may require treatment for dryness and/or inflammation of the airways. Airway disease has little effect on respiratory function and is rarely the cause of death in Sjögren's syndrome patients. Rare respiratory complications such as amyloidosis, lymphoma or pulmonary hypertension should not be disregarded in Sjögren's syndrome patients. SN - 1600-0617 UR - https://www.unboundmedicine.com/medline/citation/27246587/Pulmonary_manifestations_of_Sjögren's_syndrome_ L2 - http://err.ersjournals.com/cgi/pmidlookup?view=long&pmid=27246587 DB - PRIME DP - Unbound Medicine ER -