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Airflow in the Human Nasal Passage and Sinuses of Chronic Rhinosinusitis Subjects.
PLoS One. 2016; 11(6):e0156379.Plos

Abstract

Endoscopic surgery is performed on patients with chronic inflammatory disease of the paranasal sinuses to improve sinus ventilation. Little is known about how sinus surgery affects sinonasal airflow. In this study nasal passage geometry was reconstructed from computed tomographic imaging from healthy normal, pre-operative, and post-operative subjects. Transient air flow through the nasal passage during calm breathing was simulated. Subject-specific differences in ventilation of the nasal passage were observed. Velocity magnitude at ostium was different between left and right airway. In FESS, airflow in post-surgical subjects, airflow at the maxillary sinus ostium was upto ten times higher during inspiration. In a Lothrop procedure, airflow at the frontal sinus ostium can be upto four times higher during inspiration. In both post-operative subjects, airflow at ostium was not quasi-steady. The subject-specific effect (of surgery) on sinonasal interaction evaluated through airflow simulations may have important consequences for pre- and post-surgical assessment and surgical planning, and design for improvement of the delivery efficiency of nasal therapeutics.

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Authors+Show Affiliations

Kumar H
Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Jain R
Department of surgery, The University of Auckland, Auckland, New Zealand.
Douglas RG
Department of surgery, The University of Auckland, Auckland, New Zealand.
Tawhai MH
Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.

MeSH

HumansNasal CavityParanasal SinusesSinusitisTomography, X-Ray Computed

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27249219

Citation

Kumar, Haribalan, et al. "Airflow in the Human Nasal Passage and Sinuses of Chronic Rhinosinusitis Subjects." PloS One, vol. 11, no. 6, 2016, pp. e0156379.
Kumar H, Jain R, Douglas RG, et al. Airflow in the Human Nasal Passage and Sinuses of Chronic Rhinosinusitis Subjects. PLoS One. 2016;11(6):e0156379.
Kumar, H., Jain, R., Douglas, R. G., & Tawhai, M. H. (2016). Airflow in the Human Nasal Passage and Sinuses of Chronic Rhinosinusitis Subjects. PloS One, 11(6), e0156379. https://doi.org/10.1371/journal.pone.0156379
Kumar H, et al. Airflow in the Human Nasal Passage and Sinuses of Chronic Rhinosinusitis Subjects. PLoS One. 2016;11(6):e0156379. PubMed PMID: 27249219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airflow in the Human Nasal Passage and Sinuses of Chronic Rhinosinusitis Subjects. AU - Kumar,Haribalan, AU - Jain,Ravi, AU - Douglas,Richard G, AU - Tawhai,Merryn H, Y1 - 2016/06/01/ PY - 2015/07/09/received PY - 2016/05/13/accepted PY - 2016/6/2/entrez PY - 2016/6/2/pubmed PY - 2017/7/18/medline SP - e0156379 EP - e0156379 JF - PloS one JO - PLoS One VL - 11 IS - 6 N2 - Endoscopic surgery is performed on patients with chronic inflammatory disease of the paranasal sinuses to improve sinus ventilation. Little is known about how sinus surgery affects sinonasal airflow. In this study nasal passage geometry was reconstructed from computed tomographic imaging from healthy normal, pre-operative, and post-operative subjects. Transient air flow through the nasal passage during calm breathing was simulated. Subject-specific differences in ventilation of the nasal passage were observed. Velocity magnitude at ostium was different between left and right airway. In FESS, airflow in post-surgical subjects, airflow at the maxillary sinus ostium was upto ten times higher during inspiration. In a Lothrop procedure, airflow at the frontal sinus ostium can be upto four times higher during inspiration. In both post-operative subjects, airflow at ostium was not quasi-steady. The subject-specific effect (of surgery) on sinonasal interaction evaluated through airflow simulations may have important consequences for pre- and post-surgical assessment and surgical planning, and design for improvement of the delivery efficiency of nasal therapeutics. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27249219/Airflow_in_the_Human_Nasal_Passage_and_Sinuses_of_Chronic_Rhinosinusitis_Subjects_ DB - PRIME DP - Unbound Medicine ER -