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Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection.
Am J Clin Nutr 2016; 103(6):1434-42AJ

Abstract

BACKGROUND

Urinary tract infections (UTIs) are among the most common bacterial infections and are often treated with antibiotics. Concerns about multidrug-resistant uropathogens have pointed to the need for safe and effective UTI-prevention strategies such as cranberry consumption.

OBJECTIVE

We assessed the effects of the consumption of a cranberry beverage on episodes of clinical UTIs.

DESIGN

In this randomized, double-blind, placebo-controlled, multicenter clinical trial, women with a history of a recent UTI were assigned to consume one 240-mL serving of cranberry beverage/d (n = 185) or a placebo (n = 188) beverage for 24 wk. The primary outcome was the clinical UTI incidence density, which was defined as the total number of clinical UTI events (including multiple events per subject when applicable) per unit of observation time.

RESULTS

The dates of the random assignment of the first subject and the last subject's final visit were February 2013 and March 2015, respectively. The mean age was 40.9 y, and characteristics were similar in both groups. Compliance with study product consumption was 98%, and 86% of subjects completed the treatment period in both groups. There were 39 investigator-diagnosed episodes of clinical UTI in the cranberry group compared with 67 episodes in the placebo group (antibiotic use-adjusted incidence rate ratio: 0.61; 95% CI: 0.41, 0.91; P = 0.016). Clinical UTI with pyuria was also significantly reduced (incidence rate ratio: 0.63; 95% CI: 0.40, 0.97; P = 0.037). One clinical UTI event was prevented for every 3.2 woman-years (95% CI: 2.0, 13.1 woman-years) of the cranberry intervention. The time to UTI with culture positivity did not differ significantly between groups (HR: 0.97; 95% CI: 0.56, 1.67; P = 0.914).

CONCLUSION

The consumption of a cranberry juice beverage lowered the number of clinical UTI episodes in women with a recent history of UTI. This study was registered at clinicaltrials.gov as NCT01776021.

Authors+Show Affiliations

Biofortis Clinical Research, Addison, IL; MB Clinical Research, Glen Ellyn, IL; kmaki@mbclinicalresearch.com.Ocean Spray Cranberries, Lakeville-Middleboro, MA;Ocean Spray Cranberries, Lakeville-Middleboro, MA;Biofortis Clinical Research, Addison, IL;Biofortis Clinical Research, Addison, IL;Department of Medicine, Boston University School of Medicine, Boston, MA; and VA Boston Healthcare System, Boston, MA.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27251185

Citation

Maki, Kevin C., et al. "Consumption of a Cranberry Juice Beverage Lowered the Number of Clinical Urinary Tract Infection Episodes in Women With a Recent History of Urinary Tract Infection." The American Journal of Clinical Nutrition, vol. 103, no. 6, 2016, pp. 1434-42.
Maki KC, Kaspar KL, Khoo C, et al. Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. Am J Clin Nutr. 2016;103(6):1434-42.
Maki, K. C., Kaspar, K. L., Khoo, C., Derrig, L. H., Schild, A. L., & Gupta, K. (2016). Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. The American Journal of Clinical Nutrition, 103(6), pp. 1434-42. doi:10.3945/ajcn.116.130542.
Maki KC, et al. Consumption of a Cranberry Juice Beverage Lowered the Number of Clinical Urinary Tract Infection Episodes in Women With a Recent History of Urinary Tract Infection. Am J Clin Nutr. 2016;103(6):1434-42. PubMed PMID: 27251185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. AU - Maki,Kevin C, AU - Kaspar,Kerrie L, AU - Khoo,Christina, AU - Derrig,Linda H, AU - Schild,Arianne L, AU - Gupta,Kalpana, PY - 2016/01/11/received PY - 2016/03/17/accepted PY - 2016/6/3/entrez PY - 2016/6/3/pubmed PY - 2017/5/27/medline KW - antibiotics KW - bacteria KW - cranberry KW - inflammation KW - proanthocyanidin KW - urinary tract infection KW - women SP - 1434 EP - 42 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 103 IS - 6 N2 - BACKGROUND: Urinary tract infections (UTIs) are among the most common bacterial infections and are often treated with antibiotics. Concerns about multidrug-resistant uropathogens have pointed to the need for safe and effective UTI-prevention strategies such as cranberry consumption. OBJECTIVE: We assessed the effects of the consumption of a cranberry beverage on episodes of clinical UTIs. DESIGN: In this randomized, double-blind, placebo-controlled, multicenter clinical trial, women with a history of a recent UTI were assigned to consume one 240-mL serving of cranberry beverage/d (n = 185) or a placebo (n = 188) beverage for 24 wk. The primary outcome was the clinical UTI incidence density, which was defined as the total number of clinical UTI events (including multiple events per subject when applicable) per unit of observation time. RESULTS: The dates of the random assignment of the first subject and the last subject's final visit were February 2013 and March 2015, respectively. The mean age was 40.9 y, and characteristics were similar in both groups. Compliance with study product consumption was 98%, and 86% of subjects completed the treatment period in both groups. There were 39 investigator-diagnosed episodes of clinical UTI in the cranberry group compared with 67 episodes in the placebo group (antibiotic use-adjusted incidence rate ratio: 0.61; 95% CI: 0.41, 0.91; P = 0.016). Clinical UTI with pyuria was also significantly reduced (incidence rate ratio: 0.63; 95% CI: 0.40, 0.97; P = 0.037). One clinical UTI event was prevented for every 3.2 woman-years (95% CI: 2.0, 13.1 woman-years) of the cranberry intervention. The time to UTI with culture positivity did not differ significantly between groups (HR: 0.97; 95% CI: 0.56, 1.67; P = 0.914). CONCLUSION: The consumption of a cranberry juice beverage lowered the number of clinical UTI episodes in women with a recent history of UTI. This study was registered at clinicaltrials.gov as NCT01776021. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/27251185/Consumption_of_a_cranberry_juice_beverage_lowered_the_number_of_clinical_urinary_tract_infection_episodes_in_women_with_a_recent_history_of_urinary_tract_infection_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.116.130542 DB - PRIME DP - Unbound Medicine ER -