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The role of vitamin K in vascular calcification of patients with chronic kidney disease.
Acta Clin Belg. 2016 Dec; 71(6):462-467.AC

Abstract

Patients with chronic kidney disease (CKD) are prone to vascular calcification. Pathogenetic mechanisms of vascular calcifications have been broadly studied and discussed such as the role of hyperphosphatemia, hypercalcemia, parathormone, and vitamin D. In recent years, new insights have been gained pointing to vitamin K as a main actor. It has been discovered that vitamin K is an essential cofactor for the activation of matrix Gla protein (MGP), a calcification inhibitor in the vessel wall. Patients with CKD often suffer from vitamin K deficiency, resulting in low active MGP and eventually a lack of inhibition of vascular calcification. Vitamin K supplementation and switching warfarin to new oral anticoagulants are potential treatments. In addition, MGP may have a role as a non-invasive biomarker for vascular calcification.

Authors+Show Affiliations

Wuyts J
a Department of Internal Medicine, Renal Division , Ghent University Hospital , Ghent , Belgium.
Dhondt A
a Department of Internal Medicine, Renal Division , Ghent University Hospital , Ghent , Belgium.

MeSH

BiomarkersDietary SupplementsHumansRenal Insufficiency, ChronicVascular CalcificationVitamin KVitamins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27254816

Citation

Wuyts, Julie, and Annemieke Dhondt. "The Role of Vitamin K in Vascular Calcification of Patients With Chronic Kidney Disease." Acta Clinica Belgica, vol. 71, no. 6, 2016, pp. 462-467.
Wuyts J, Dhondt A. The role of vitamin K in vascular calcification of patients with chronic kidney disease. Acta Clin Belg. 2016;71(6):462-467.
Wuyts, J., & Dhondt, A. (2016). The role of vitamin K in vascular calcification of patients with chronic kidney disease. Acta Clinica Belgica, 71(6), 462-467.
Wuyts J, Dhondt A. The Role of Vitamin K in Vascular Calcification of Patients With Chronic Kidney Disease. Acta Clin Belg. 2016;71(6):462-467. PubMed PMID: 27254816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of vitamin K in vascular calcification of patients with chronic kidney disease. AU - Wuyts,Julie, AU - Dhondt,Annemieke, Y1 - 2016/05/25/ PY - 2016/6/3/pubmed PY - 2017/4/5/medline PY - 2016/6/3/entrez KW - Chronic kidney disease KW - Matrix Gla protein (MGP) KW - Vascular calcification KW - Vitamin K KW - Warfarin SP - 462 EP - 467 JF - Acta clinica Belgica JO - Acta Clin Belg VL - 71 IS - 6 N2 - Patients with chronic kidney disease (CKD) are prone to vascular calcification. Pathogenetic mechanisms of vascular calcifications have been broadly studied and discussed such as the role of hyperphosphatemia, hypercalcemia, parathormone, and vitamin D. In recent years, new insights have been gained pointing to vitamin K as a main actor. It has been discovered that vitamin K is an essential cofactor for the activation of matrix Gla protein (MGP), a calcification inhibitor in the vessel wall. Patients with CKD often suffer from vitamin K deficiency, resulting in low active MGP and eventually a lack of inhibition of vascular calcification. Vitamin K supplementation and switching warfarin to new oral anticoagulants are potential treatments. In addition, MGP may have a role as a non-invasive biomarker for vascular calcification. SN - 2295-3337 UR - https://www.unboundmedicine.com/medline/citation/27254816/The_role_of_vitamin_K_in_vascular_calcification_of_patients_with_chronic_kidney_disease_ DB - PRIME DP - Unbound Medicine ER -