Tags

Type your tag names separated by a space and hit enter

Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake.
J Agric Food Chem. 2016 Jun 22; 64(24):4891-9.JA

Abstract

Plasma strawberry anthocyanins were characterized in overweight (BMI: 26 ± 2 kg/m(2)) adults (n = 14) on the basis of meal timing. At each visit, subjects ingested three study drinks: two control and one strawberry drink. A strawberry drink was given at either 2 h before the breakfast meal (BM), with the meal (WM), or 2 h after the meal (AM), and control drinks were given at the alternative time points. Plasma anthocyanins and their metabolic conjugates were assessed hourly for 10 h using a triple-quadrupole liquid chromatography mass spectrometer. Maximum concentrations (Cmax), area under the curve (AUC), and bioavailability of pelargonidin-based anthocyanins determined from the main conjugated metabolite (pelargonidin glucuronide) were greater when a strawberry drink was consumed 2 h before the meal (BM) compared to consumption WM or AM (p < 0.05). Our results indicate that the timing of strawberry consumption relative to a meal impacts anthocyanin pharmacokinetic variables.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Sandhu AK
Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
Huang Y
Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
Xiao D
Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
Park E
Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
Edirisinghe I
Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
Burton-Freeman B
Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States. Department of Nutrition, University of California , Davis, California 95616, United States.

MeSH

AdultAnthocyaninsBiological AvailabilityFemaleFragariaFruitFruit and Vegetable JuicesHumansMaleMiddle AgedYoung Adult

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27255121

Citation

Sandhu, Amandeep K., et al. "Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake." Journal of Agricultural and Food Chemistry, vol. 64, no. 24, 2016, pp. 4891-9.
Sandhu AK, Huang Y, Xiao D, et al. Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake. J Agric Food Chem. 2016;64(24):4891-9.
Sandhu, A. K., Huang, Y., Xiao, D., Park, E., Edirisinghe, I., & Burton-Freeman, B. (2016). Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake. Journal of Agricultural and Food Chemistry, 64(24), 4891-9. https://doi.org/10.1021/acs.jafc.6b00805
Sandhu AK, et al. Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake. J Agric Food Chem. 2016 Jun 22;64(24):4891-9. PubMed PMID: 27255121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake. AU - Sandhu,Amandeep K, AU - Huang,Yancui, AU - Xiao,Di, AU - Park,Eunyoung, AU - Edirisinghe,Indika, AU - Burton-Freeman,Britt, Y1 - 2016/06/13/ PY - 2016/6/4/entrez PY - 2016/6/4/pubmed PY - 2017/4/18/medline KW - HPLC KW - anthocyanins KW - bioavailability KW - glucuronide KW - strawberries SP - 4891 EP - 9 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 64 IS - 24 N2 - Plasma strawberry anthocyanins were characterized in overweight (BMI: 26 ± 2 kg/m(2)) adults (n = 14) on the basis of meal timing. At each visit, subjects ingested three study drinks: two control and one strawberry drink. A strawberry drink was given at either 2 h before the breakfast meal (BM), with the meal (WM), or 2 h after the meal (AM), and control drinks were given at the alternative time points. Plasma anthocyanins and their metabolic conjugates were assessed hourly for 10 h using a triple-quadrupole liquid chromatography mass spectrometer. Maximum concentrations (Cmax), area under the curve (AUC), and bioavailability of pelargonidin-based anthocyanins determined from the main conjugated metabolite (pelargonidin glucuronide) were greater when a strawberry drink was consumed 2 h before the meal (BM) compared to consumption WM or AM (p < 0.05). Our results indicate that the timing of strawberry consumption relative to a meal impacts anthocyanin pharmacokinetic variables. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/27255121/Pharmacokinetic_Characterization_and_Bioavailability_of_Strawberry_Anthocyanins_Relative_to_Meal_Intake_ DB - PRIME DP - Unbound Medicine ER -