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Field synopsis and meta-analyses of genetic epidemiological evidence for Kashin-Beck disease, an endemic osteoarthropathy in China.
Mol Genet Genomics. 2016 Oct; 291(5):1823-33.MG

Abstract

Kashin-Beck disease (KBD) is a chronic degenerative osteoarthropathy with unclear etiology. To provide current evidence supporting a genetic predisposition for KBD, we conducted a systematic review and meta-analysis of published literature on the genetic epidemiology of KBD. The PubMed, China National Knowledge Infrastructure and Wan Fang Data were searched up to August 2015 for articles published in English and Chinese. Genome-wide and exome sequencing, linkage, and case-control association studies for any genetic variants associated with KBD were included. Meta-analysis was performed for all single nucleotide polymorphisms (SNPs) that were evaluated in two or more studies. The effect size was summarized as odds ratios (ORs) with 95 % confidence intervals (CIs) by fixed and random effects models. A total of 24 articles were systematically reviewed. Eleven short tandem repeats on chromosomes 2, 11 and 12, 34 SNPs in 12 genes, as well as copy number variant 452 were identified as KBD susceptibility factors in individual studies. The meta-analysis of the GPX1 rs1050450, DIO2 rs225014, TrxR2 rs5748469 and HLA-DRB1 rs7745040 failed to reveal any associations with KBD. However, the meta-analysis of HLA-DRB1 rs9275295 allele A was associated with KBD (OR = 1.737, 95 % CI: 1.002-3.012). In addition, seven haplotypes in GPX1, GPX4, HLA-DRB1 and GDF5 genes also showed significant associations with KBD. In conclusions, our study could identify a number of genetic markers associated with KBD. However, the evidence does not currently support a strong association between the specific variants and KBD because of the limited number of studies, and in the future, more rigorous studies are needed to confirm KBD's links with these variants.

Authors+Show Affiliations

School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Xi'an, Shaanxi, People's Republic of China.Hong Hui Hospital, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Xi'an, Shaanxi, People's Republic of China.School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Xi'an, Shaanxi, People's Republic of China.School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Xi'an, Shaanxi, People's Republic of China. guox@mail.xjtu.edu.cn.School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Xi'an, Shaanxi, People's Republic of China. mikko.lammi@umu.se. Department of Integrative Medical Biology, University of Umeå, Umeå, Sweden. mikko.lammi@umu.se.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

27256326

Citation

Yang, Lei, et al. "Field Synopsis and Meta-analyses of Genetic Epidemiological Evidence for Kashin-Beck Disease, an Endemic Osteoarthropathy in China." Molecular Genetics and Genomics : MGG, vol. 291, no. 5, 2016, pp. 1823-33.
Yang L, Zhao GH, Liu H, et al. Field synopsis and meta-analyses of genetic epidemiological evidence for Kashin-Beck disease, an endemic osteoarthropathy in China. Mol Genet Genomics. 2016;291(5):1823-33.
Yang, L., Zhao, G. H., Liu, H., Wang, X., Guo, X., & Lammi, M. J. (2016). Field synopsis and meta-analyses of genetic epidemiological evidence for Kashin-Beck disease, an endemic osteoarthropathy in China. Molecular Genetics and Genomics : MGG, 291(5), 1823-33. https://doi.org/10.1007/s00438-016-1222-z
Yang L, et al. Field Synopsis and Meta-analyses of Genetic Epidemiological Evidence for Kashin-Beck Disease, an Endemic Osteoarthropathy in China. Mol Genet Genomics. 2016;291(5):1823-33. PubMed PMID: 27256326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Field synopsis and meta-analyses of genetic epidemiological evidence for Kashin-Beck disease, an endemic osteoarthropathy in China. AU - Yang,Lei, AU - Zhao,Guang-Hui, AU - Liu,Huan, AU - Wang,Xi, AU - Guo,Xiong, AU - Lammi,Mikko J, Y1 - 2016/06/02/ PY - 2016/04/11/received PY - 2016/05/24/accepted PY - 2016/6/4/entrez PY - 2016/6/4/pubmed PY - 2017/1/31/medline KW - Genetics KW - Kashin–Beck disease KW - Polymorphism KW - Systematic review SP - 1823 EP - 33 JF - Molecular genetics and genomics : MGG JO - Mol. Genet. Genomics VL - 291 IS - 5 N2 - Kashin-Beck disease (KBD) is a chronic degenerative osteoarthropathy with unclear etiology. To provide current evidence supporting a genetic predisposition for KBD, we conducted a systematic review and meta-analysis of published literature on the genetic epidemiology of KBD. The PubMed, China National Knowledge Infrastructure and Wan Fang Data were searched up to August 2015 for articles published in English and Chinese. Genome-wide and exome sequencing, linkage, and case-control association studies for any genetic variants associated with KBD were included. Meta-analysis was performed for all single nucleotide polymorphisms (SNPs) that were evaluated in two or more studies. The effect size was summarized as odds ratios (ORs) with 95 % confidence intervals (CIs) by fixed and random effects models. A total of 24 articles were systematically reviewed. Eleven short tandem repeats on chromosomes 2, 11 and 12, 34 SNPs in 12 genes, as well as copy number variant 452 were identified as KBD susceptibility factors in individual studies. The meta-analysis of the GPX1 rs1050450, DIO2 rs225014, TrxR2 rs5748469 and HLA-DRB1 rs7745040 failed to reveal any associations with KBD. However, the meta-analysis of HLA-DRB1 rs9275295 allele A was associated with KBD (OR = 1.737, 95 % CI: 1.002-3.012). In addition, seven haplotypes in GPX1, GPX4, HLA-DRB1 and GDF5 genes also showed significant associations with KBD. In conclusions, our study could identify a number of genetic markers associated with KBD. However, the evidence does not currently support a strong association between the specific variants and KBD because of the limited number of studies, and in the future, more rigorous studies are needed to confirm KBD's links with these variants. SN - 1617-4623 UR - https://www.unboundmedicine.com/medline/citation/27256326/Field_synopsis_and_meta_analyses_of_genetic_epidemiological_evidence_for_Kashin_Beck_disease_an_endemic_osteoarthropathy_in_China_ L2 - https://dx.doi.org/10.1007/s00438-016-1222-z DB - PRIME DP - Unbound Medicine ER -