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Prenatal marijuana exposure impacts executive functioning into young adulthood: An fMRI study.
Neurotoxicol Teratol. 2016 Nov - Dec; 58:53-59.NT

Abstract

Understanding the potentially harmful long term consequences of prenatal marijuana exposure is important given the increase in number of pregnant women smoking marijuana to relieve morning sickness. Altered executive functioning is one area of research that has suggested negative consequences of prenatal marijuana exposure into adolescence. Investigating if these findings continue into young adulthood and exploring the neural basis of these effects was the purpose of this research. Thirty one young adults (ages 18-22years) from the longitudinal Ottawa Prenatal Prospective Study (OPPS) underwent functional magnetic resonance imaging (fMRI) during four tasks; 1) Visuospatial 2-Back, 2) Go/NoGo, 3) Letter 2-Back and 4) Counting Stroop task. Sixteen participants were prenatally exposed to marijuana while 15 had no prenatal marijuana exposure. Task performance was similar for both groups but blood flow was significantly different between the groups. This paper presents the results for all 4 tasks, highlighting the consistently increased left posterior brain activity in the prenatally exposed group compared with the control group. These alterations in neurophysiological functioning of young adults prenatally exposed to marijuana emphasizes the importance of education for women in child bearing years, as well as for policy makers and physicians interested in the welfare of both the pregnant women and their offspring's future success.

Authors+Show Affiliations

University of Ottawa, School of Psychology, Ottawa, ON K1N 6N5, Canada. Electronic address: asmith@uottawa.ca.University of Ottawa, School of Psychology, Ottawa, ON K1N 6N5, Canada.University of Ottawa, School of Psychology, Ottawa, ON K1N 6N5, Canada.University of Ottawa, School of Psychology, Ottawa, ON K1N 6N5, Canada.University of Ottawa, School of Psychology, Ottawa, ON K1N 6N5, Canada.Carleton University, Department of Psychology, Ottawa, ON, Canada.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27263090

Citation

Smith, Andra M., et al. "Prenatal Marijuana Exposure Impacts Executive Functioning Into Young Adulthood: an fMRI Study." Neurotoxicology and Teratology, vol. 58, 2016, pp. 53-59.
Smith AM, Mioduszewski O, Hatchard T, et al. Prenatal marijuana exposure impacts executive functioning into young adulthood: An fMRI study. Neurotoxicol Teratol. 2016;58:53-59.
Smith, A. M., Mioduszewski, O., Hatchard, T., Byron-Alhassan, A., Fall, C., & Fried, P. A. (2016). Prenatal marijuana exposure impacts executive functioning into young adulthood: An fMRI study. Neurotoxicology and Teratology, 58, 53-59. https://doi.org/10.1016/j.ntt.2016.05.010
Smith AM, et al. Prenatal Marijuana Exposure Impacts Executive Functioning Into Young Adulthood: an fMRI Study. Neurotoxicol Teratol. 2016 Nov - Dec;58:53-59. PubMed PMID: 27263090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal marijuana exposure impacts executive functioning into young adulthood: An fMRI study. AU - Smith,Andra M, AU - Mioduszewski,Ola, AU - Hatchard,Taylor, AU - Byron-Alhassan,Aziza, AU - Fall,Carley, AU - Fried,Peter A, Y1 - 2016/06/01/ PY - 2015/10/02/received PY - 2016/05/04/revised PY - 2016/05/31/accepted PY - 2016/6/6/pubmed PY - 2017/12/23/medline PY - 2016/6/6/entrez KW - Cognition KW - Impulsivity KW - Neurophysiology KW - Prenatal marijuana KW - Working memory KW - fMRI SP - 53 EP - 59 JF - Neurotoxicology and teratology JO - Neurotoxicol Teratol VL - 58 N2 - Understanding the potentially harmful long term consequences of prenatal marijuana exposure is important given the increase in number of pregnant women smoking marijuana to relieve morning sickness. Altered executive functioning is one area of research that has suggested negative consequences of prenatal marijuana exposure into adolescence. Investigating if these findings continue into young adulthood and exploring the neural basis of these effects was the purpose of this research. Thirty one young adults (ages 18-22years) from the longitudinal Ottawa Prenatal Prospective Study (OPPS) underwent functional magnetic resonance imaging (fMRI) during four tasks; 1) Visuospatial 2-Back, 2) Go/NoGo, 3) Letter 2-Back and 4) Counting Stroop task. Sixteen participants were prenatally exposed to marijuana while 15 had no prenatal marijuana exposure. Task performance was similar for both groups but blood flow was significantly different between the groups. This paper presents the results for all 4 tasks, highlighting the consistently increased left posterior brain activity in the prenatally exposed group compared with the control group. These alterations in neurophysiological functioning of young adults prenatally exposed to marijuana emphasizes the importance of education for women in child bearing years, as well as for policy makers and physicians interested in the welfare of both the pregnant women and their offspring's future success. SN - 1872-9738 UR - https://www.unboundmedicine.com/medline/citation/27263090/Prenatal_marijuana_exposure_impacts_executive_functioning_into_young_adulthood:_An_fMRI_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0892-0362(16)30055-1 DB - PRIME DP - Unbound Medicine ER -