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Robot-assisted spleen preserving pancreatic surgery in MEN1 patients.
J Surg Oncol. 2016 Sep; 114(4):456-61.JS

Abstract

BACKGROUND

Multiple Endocrine Neoplasia type 1 (MEN1) patients often undergo multiple pancreatic operations at a young age.

OBJECTIVE

To describe robot-assisted and laparoscopic spleen-preserving pancreatic surgery in MEN1 patients, and to compare both techniques.

METHODS

Robot-assisted pancreatectomies of the DutchMEN1 study group and the Université de Lorraine, Nancy, France were compared to a historical cohort of laparoscopic treated MEN1 patients. Perioperative outcomes were compared.

RESULTS

A total of 21 MEN1 patients underwent minimally invasive pancreatic surgery for pancreatic neuroendocrine tumors, seven patients were subjected to robot-assisted surgery, and 14 patients underwent laparoscopic surgery. Demographics and clinical characteristics did not differ between the cohorts and no significant differences in operative outcomes were found. A high number of ISGPS grade B/C pancreatic fistulas were observed in both cohorts (38%), and no conversions were seen in the robot-assisted cohort (respectively 0% vs. 43%, P = 0.06). In one laparoscopic and one robot-assisted case the primary tumor was not resected.

CONCLUSIONS

Minimally invasive spleen-preserving surgery in MEN1 patients is safe and feasible. Patients who underwent robot-assisted surgery did not require conversion to open surgery. J. Surg. Oncol. 2016;114:456-461. © 2016 Wiley Periodicals, Inc.

Authors+Show Affiliations

Department of Endocrine Surgical Oncology and Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.Department of Digestive, Hepatobiliary and Endocrine Surgery, Université de Lorraine, Hôpital Brabois Adultes, CHU Nancy, Nancy, France.Department of Digestive, Hepatobiliary and Endocrine Surgery, Université de Lorraine, Hôpital Brabois Adultes, CHU Nancy, Nancy, France.Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands.Department of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Surgical Oncology and Hepato-Pancreato-Biliary Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.Department of Surgical Oncology and Hepato-Pancreato-Biliary Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.No affiliation info availableDepartment of Surgical Oncology and Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27263513

Citation

Nell, Sjoerd, et al. "Robot-assisted Spleen Preserving Pancreatic Surgery in MEN1 Patients." Journal of Surgical Oncology, vol. 114, no. 4, 2016, pp. 456-61.
Nell S, Brunaud L, Ayav A, et al. Robot-assisted spleen preserving pancreatic surgery in MEN1 patients. J Surg Oncol. 2016;114(4):456-61.
Nell, S., Brunaud, L., Ayav, A., Bonsing, B. A., Groot Koerkamp, B., Nieveen van Dijkum, E. J., Kazemier, G., de Kleine, R. H., Hagendoorn, J., Molenaar, I. Q., Valk, G. D., Borel Rinkes, I. H., & Vriens, M. R. (2016). Robot-assisted spleen preserving pancreatic surgery in MEN1 patients. Journal of Surgical Oncology, 114(4), 456-61. https://doi.org/10.1002/jso.24315
Nell S, et al. Robot-assisted Spleen Preserving Pancreatic Surgery in MEN1 Patients. J Surg Oncol. 2016;114(4):456-61. PubMed PMID: 27263513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Robot-assisted spleen preserving pancreatic surgery in MEN1 patients. AU - Nell,Sjoerd, AU - Brunaud,Laurent, AU - Ayav,Ahmet, AU - Bonsing,Bert A, AU - Groot Koerkamp,Bas, AU - Nieveen van Dijkum,Els J, AU - Kazemier,Geert, AU - de Kleine,Ruben H J, AU - Hagendoorn,Jeroen, AU - Molenaar,I Quintus, AU - Valk,Gerlof D, AU - ,, AU - Borel Rinkes,Inne H M, AU - Vriens,Menno R, Y1 - 2016/06/06/ PY - 2015/09/02/received PY - 2016/05/21/accepted PY - 2016/6/7/entrez PY - 2016/6/7/pubmed PY - 2017/2/10/medline KW - laparoscopic pancreatic surgery KW - multiple endocrine neoplasia type 1 KW - neuroendocrine tumors KW - pancreas KW - robot-assisted pancreatic surgery SP - 456 EP - 61 JF - Journal of surgical oncology JO - J Surg Oncol VL - 114 IS - 4 N2 - BACKGROUND: Multiple Endocrine Neoplasia type 1 (MEN1) patients often undergo multiple pancreatic operations at a young age. OBJECTIVE: To describe robot-assisted and laparoscopic spleen-preserving pancreatic surgery in MEN1 patients, and to compare both techniques. METHODS: Robot-assisted pancreatectomies of the DutchMEN1 study group and the Université de Lorraine, Nancy, France were compared to a historical cohort of laparoscopic treated MEN1 patients. Perioperative outcomes were compared. RESULTS: A total of 21 MEN1 patients underwent minimally invasive pancreatic surgery for pancreatic neuroendocrine tumors, seven patients were subjected to robot-assisted surgery, and 14 patients underwent laparoscopic surgery. Demographics and clinical characteristics did not differ between the cohorts and no significant differences in operative outcomes were found. A high number of ISGPS grade B/C pancreatic fistulas were observed in both cohorts (38%), and no conversions were seen in the robot-assisted cohort (respectively 0% vs. 43%, P = 0.06). In one laparoscopic and one robot-assisted case the primary tumor was not resected. CONCLUSIONS: Minimally invasive spleen-preserving surgery in MEN1 patients is safe and feasible. Patients who underwent robot-assisted surgery did not require conversion to open surgery. J. Surg. Oncol. 2016;114:456-461. © 2016 Wiley Periodicals, Inc. SN - 1096-9098 UR - https://www.unboundmedicine.com/medline/citation/27263513/Robot_assisted_spleen_preserving_pancreatic_surgery_in_MEN1_patients_ L2 - https://doi.org/10.1002/jso.24315 DB - PRIME DP - Unbound Medicine ER -