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Cannabinoid 2 (CB2) receptor agonism reduces lithium chloride-induced vomiting in Suncus murinus and nausea-induced conditioned gaping in rats.
Eur J Pharmacol. 2016 Sep 05; 786:94-99.EJ

Abstract

We aimed to investigate the potential anti-emetic and anti-nausea properties of targeting the cannabinoid 2 (CB2) receptor. We investigated the effect of the selective CB2 agonist, HU-308, on lithium chloride- (LiCl) induced vomiting in Suncus murinus (S. murinus) and conditioned gaping (nausea-induced behaviour) in rats. Additionally, we determined whether these effects could be prevented by pretreatment with AM630 (a selective CB2 receptor antagonist/inverse agonist). In S. murinus, HU-308 (2.5, 5mg/kg, i.p.) reduced, but did not completely block, LiCl-induced vomiting; an effect that was prevented with AM630. In rats, HU-308 (5mg/kg, i.p.) suppressed, but did not completely block, LiCl-induced conditioned gaping to a flavour; an effect that was prevented by AM630. These findings are the first to demonstrate the ability of a selective CB2 receptor agonist to reduce nausea in animal models, indicating that targeting the CB2 receptor may be an effective strategy, devoid of psychoactive effects, for managing toxin-induced nausea and vomiting.

Authors+Show Affiliations

Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada.Institute of Drug Research, Hebrew University of Jerusalem, Jerusalem, Israel.Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada. Electronic address: parkerl@uoguelph.ca.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27263826

Citation

Rock, Erin M., et al. "Cannabinoid 2 (CB2) Receptor Agonism Reduces Lithium Chloride-induced Vomiting in Suncus Murinus and Nausea-induced Conditioned Gaping in Rats." European Journal of Pharmacology, vol. 786, 2016, pp. 94-99.
Rock EM, Boulet N, Limebeer CL, et al. Cannabinoid 2 (CB2) receptor agonism reduces lithium chloride-induced vomiting in Suncus murinus and nausea-induced conditioned gaping in rats. Eur J Pharmacol. 2016;786:94-99.
Rock, E. M., Boulet, N., Limebeer, C. L., Mechoulam, R., & Parker, L. A. (2016). Cannabinoid 2 (CB2) receptor agonism reduces lithium chloride-induced vomiting in Suncus murinus and nausea-induced conditioned gaping in rats. European Journal of Pharmacology, 786, 94-99. https://doi.org/10.1016/j.ejphar.2016.06.001
Rock EM, et al. Cannabinoid 2 (CB2) Receptor Agonism Reduces Lithium Chloride-induced Vomiting in Suncus Murinus and Nausea-induced Conditioned Gaping in Rats. Eur J Pharmacol. 2016 Sep 5;786:94-99. PubMed PMID: 27263826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabinoid 2 (CB2) receptor agonism reduces lithium chloride-induced vomiting in Suncus murinus and nausea-induced conditioned gaping in rats. AU - Rock,Erin M, AU - Boulet,Nathalie, AU - Limebeer,Cheryl L, AU - Mechoulam,Raphael, AU - Parker,Linda A, Y1 - 2016/06/02/ PY - 2015/11/16/received PY - 2016/05/20/revised PY - 2016/06/01/accepted PY - 2016/6/7/entrez PY - 2016/6/7/pubmed PY - 2017/3/11/medline KW - AM630 KW - AM630 (PubChem CID: 4302963) KW - Acute nausea KW - CB(2) receptor KW - Conditioned gaping KW - HU-308 KW - HU-308 (PubChem CID: 9844711) KW - Lithium chloride (PubChem CID: 433294) KW - Vomiting SP - 94 EP - 99 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 786 N2 - We aimed to investigate the potential anti-emetic and anti-nausea properties of targeting the cannabinoid 2 (CB2) receptor. We investigated the effect of the selective CB2 agonist, HU-308, on lithium chloride- (LiCl) induced vomiting in Suncus murinus (S. murinus) and conditioned gaping (nausea-induced behaviour) in rats. Additionally, we determined whether these effects could be prevented by pretreatment with AM630 (a selective CB2 receptor antagonist/inverse agonist). In S. murinus, HU-308 (2.5, 5mg/kg, i.p.) reduced, but did not completely block, LiCl-induced vomiting; an effect that was prevented with AM630. In rats, HU-308 (5mg/kg, i.p.) suppressed, but did not completely block, LiCl-induced conditioned gaping to a flavour; an effect that was prevented by AM630. These findings are the first to demonstrate the ability of a selective CB2 receptor agonist to reduce nausea in animal models, indicating that targeting the CB2 receptor may be an effective strategy, devoid of psychoactive effects, for managing toxin-induced nausea and vomiting. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/27263826/Cannabinoid_2__CB2__receptor_agonism_reduces_lithium_chloride_induced_vomiting_in_Suncus_murinus_and_nausea_induced_conditioned_gaping_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(16)30361-2 DB - PRIME DP - Unbound Medicine ER -