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Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial.
Br J Nutr 2016; 116(3):534-46BJ

Abstract

Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated measurements of dietary changes during follow-up. Moreover, previous studies included healthy and selected participants who did not represent subjects at high cardiovascular risk. We used yearly repeated measurements of diet to investigate the association between fibre intake and CVD in a Mediterranean cohort of elderly adults at high cardiovascular risk. We followed-up 7216 men (55-80 years) and women (60-80 years) initially free of CVD for up to 7 years in the PREvención con DIeta MEDiterránea study (registered as ISRCTN35739639). A 137-item validated FFQ was repeated yearly to assess diet. The primary end point, confirmed by a blinded ad hoc Event Adjudication Committee, was a composite of cardiovascular death, myocardial infarction and stroke. Time-dependent Cox's regression models were used to estimate the risk of CVD according to baseline dietary exposures and to their yearly updated changes. We found a significant inverse association for fibre (P for trend=0·020) and fruits (P for trend=0·024) in age-sex adjusted models, but the statistical significance was lost in fully adjusted models. However, we found a significant inverse association with CVD incidence for the sum of fruit and vegetable consumption. Participants who consumed in total nine or more servings/d of fruits plus vegetables had a hazard ratio 0·60 (95 % CI 0·40, 0·96) of CVD in comparison with those consuming <5 servings/d.

Authors+Show Affiliations

1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.2Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn),Instituto de Salud Carlos III,28029-Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.2Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn),Instituto de Salud Carlos III,28029-Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.2Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn),Instituto de Salud Carlos III,28029-Madrid,Spain.2Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn),Instituto de Salud Carlos III,28029-Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.1The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045),Madrid,Spain.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27264785

Citation

Buil-Cosiales, Pilar, et al. "Association Between Dietary Fibre Intake and Fruit, Vegetable or Whole-grain Consumption and the Risk of CVD: Results From the PREvención Con DIeta MEDiterránea (PREDIMED) Trial." The British Journal of Nutrition, vol. 116, no. 3, 2016, pp. 534-46.
Buil-Cosiales P, Toledo E, Salas-Salvadó J, et al. Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial. Br J Nutr. 2016;116(3):534-46.
Buil-Cosiales, P., Toledo, E., Salas-Salvadó, J., Zazpe, I., Farràs, M., Basterra-Gortari, F. J., ... Martínez-González, M. A. (2016). Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial. The British Journal of Nutrition, 116(3), pp. 534-46. doi:10.1017/S0007114516002099.
Buil-Cosiales P, et al. Association Between Dietary Fibre Intake and Fruit, Vegetable or Whole-grain Consumption and the Risk of CVD: Results From the PREvención Con DIeta MEDiterránea (PREDIMED) Trial. Br J Nutr. 2016;116(3):534-46. PubMed PMID: 27264785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial. AU - Buil-Cosiales,Pilar, AU - Toledo,Estefania, AU - Salas-Salvadó,Jordi, AU - Zazpe,Itziar, AU - Farràs,Marta, AU - Basterra-Gortari,Francisco Javier, AU - Diez-Espino,Javier, AU - Estruch,Ramon, AU - Corella,Dolores, AU - Ros,Emilio, AU - Marti,Amelia, AU - Gómez-Gracia,Enrique, AU - Ortega-Calvo,Manuel, AU - Arós,Fernando, AU - Moñino,Manuel, AU - Serra-Majem,Lluis, AU - Pintó,Xavier, AU - Lamuela-Raventós,Rosa Maria, AU - Babio,Nancy, AU - Gonzalez,Jose I, AU - Fitó,Montserrat, AU - Martínez-González,Miguel A, AU - ,, Y1 - 2016/06/06/ PY - 2016/6/7/entrez PY - 2016/6/7/pubmed PY - 2017/5/18/medline KW - CVD KW - DF dietary fibre KW - Dietary fibre KW - FC fruit consumption KW - Fruits KW - HR hazard ratios KW - MI myocardial infarction KW - PREDIMED PREvención con DIeta MEDiterránea KW - Primary prevention KW - T2D type 2 diabetes KW - Vegetables SP - 534 EP - 46 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 116 IS - 3 N2 - Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated measurements of dietary changes during follow-up. Moreover, previous studies included healthy and selected participants who did not represent subjects at high cardiovascular risk. We used yearly repeated measurements of diet to investigate the association between fibre intake and CVD in a Mediterranean cohort of elderly adults at high cardiovascular risk. We followed-up 7216 men (55-80 years) and women (60-80 years) initially free of CVD for up to 7 years in the PREvención con DIeta MEDiterránea study (registered as ISRCTN35739639). A 137-item validated FFQ was repeated yearly to assess diet. The primary end point, confirmed by a blinded ad hoc Event Adjudication Committee, was a composite of cardiovascular death, myocardial infarction and stroke. Time-dependent Cox's regression models were used to estimate the risk of CVD according to baseline dietary exposures and to their yearly updated changes. We found a significant inverse association for fibre (P for trend=0·020) and fruits (P for trend=0·024) in age-sex adjusted models, but the statistical significance was lost in fully adjusted models. However, we found a significant inverse association with CVD incidence for the sum of fruit and vegetable consumption. Participants who consumed in total nine or more servings/d of fruits plus vegetables had a hazard ratio 0·60 (95 % CI 0·40, 0·96) of CVD in comparison with those consuming <5 servings/d. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/27264785/Association_between_dietary_fibre_intake_and_fruit_vegetable_or_whole_grain_consumption_and_the_risk_of_CVD:_results_from_the_PREvención_con_DIeta_MEDiterránea__PREDIMED__trial_ L2 - https://www.cambridge.org/core/product/identifier/S0007114516002099/type/journal_article DB - PRIME DP - Unbound Medicine ER -