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The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status.
Lipids Health Dis. 2016 Jun 07; 15:104.LH

Abstract

BACKGROUND

Triglyceride/high-density lipoprotein-cholesterol (TG/HDL-C) ratio was a surrogate marker of IR; however, the relationship of TG/HDL-C with IR might vary by ethnicity. This study aims to investigate whether lipid ratios-TG/HDL-C, cholesterol/high-density lipoprotein-cholesterol (TC/HDL-C) ratio, low-density lipoprotein-cholesterol/high-density lipoprotein-cholesterol (LDL-C/HDL-C)) could be potential clinical markers of insulin resistance (IR) and β cell function and further to explore the optimal cut-offs in a Chinese population with different levels of glucose tolerance.

METHODS

Four hundred seventy-nine subjects without a history of diabetes underwent a 75 g 2 h Oral Glucose Tolerance Test (OGTT). New-onset diabetes (n = 101), pre-diabetes (n = 186), and normal glucose tolerance (n = 192) were screened. IR was defined by HOMA-IR > 2.69. Based on indices (HOMA-β, early-phase disposition index [DI30], (ΔIns30/ΔGlu30)/HOMA-IR and total-phase index [DI120]) that indicated different phases of insulin secretion, the subjects were divided into two groups, and the lower group was defined as having inadequate β cell compensation. Logistic regression models and accurate estimates of the areas under receiver operating characteristic curves (AUROC) were obtained.

RESULTS

In all of the subjects, TG/HDL, TC/HDL-C, LDL-C/HDL-C, and TG were significantly associated with IR. The AUROCs of TG/HDL-C and TG were 0.71 (95 % CI: 0.66-0.75) and 0.71 (95 % CI: 0.65-0.75), respectively. The optimal cut-offs of TG/HDL-C and TG for IR diagnosis were 1.11 and 1.33 mmol/L, respectively. The AUROCs of TC/HDL-C and LDL-C/HDL-C were 0.66 and 0.65, respectively, but they were not acceptable for IR diagnosis. TG/HDL-C,LDL-C/HDL-C and TG were significantly associated with HOMA-β, but AUROCs were less than 0.50; therefore, the lipid ratios could not be predictors of basal β cell dysfunction. None of the lipid ratios was associated with early-phase insulin secretion. Only TG/HDL-C and TG were significantly correlated with total-phase insulin secretion, but they also were not acceptable predictors of total-phase insulin secretion (0.60 < AUROC < 0.70).

CONCLUSIONS

In a Chinese population with different levels of glucose tolerance, TG/HDL-C and TG could be the predictors of IR. The lipid ratios could not be reliable makers of β cell function in the population.

Authors+Show Affiliations

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing, 100730, China.Nankou Community Health Service Centers, Changping District, Beijing, 102200, China.Nankou Community Health Service Centers, Changping District, Beijing, 102200, China.Nankou Railway Hospital, Changping District, Beijing, 102200, China.Nankou Railway Hospital, Changping District, Beijing, 102200, China.Department of Nutrition, Peking Union Medical College Hospital, Beijing, 100730, China.Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing, 100730, China.Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing, 100730, China.Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing, 100730, China. liyuxiu@medmail.com.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27267043

Citation

Zhou, Meicen, et al. "The Triglyceride to High-density Lipoprotein Cholesterol (TG/HDL-C) Ratio as a Predictor of Insulin Resistance but Not of Β Cell Function in a Chinese Population With Different Glucose Tolerance Status." Lipids in Health and Disease, vol. 15, 2016, p. 104.
Zhou M, Zhu L, Cui X, et al. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status. Lipids Health Dis. 2016;15:104.
Zhou, M., Zhu, L., Cui, X., Feng, L., Zhao, X., He, S., Ping, F., Li, W., & Li, Y. (2016). The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status. Lipids in Health and Disease, 15, 104. https://doi.org/10.1186/s12944-016-0270-z
Zhou M, et al. The Triglyceride to High-density Lipoprotein Cholesterol (TG/HDL-C) Ratio as a Predictor of Insulin Resistance but Not of Β Cell Function in a Chinese Population With Different Glucose Tolerance Status. Lipids Health Dis. 2016 Jun 7;15:104. PubMed PMID: 27267043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status. AU - Zhou,Meicen, AU - Zhu,Lixin, AU - Cui,Xiangli, AU - Feng,Linbo, AU - Zhao,Xuefeng, AU - He,Shuli, AU - Ping,Fan, AU - Li,Wei, AU - Li,Yuxiu, Y1 - 2016/06/07/ PY - 2015/12/23/received PY - 2016/05/23/accepted PY - 2016/6/9/entrez PY - 2016/6/9/pubmed PY - 2017/3/28/medline KW - Glucose tolerance status KW - Insulin resistance KW - Lipid ratios KW - β cell function SP - 104 EP - 104 JF - Lipids in health and disease JO - Lipids Health Dis VL - 15 N2 - BACKGROUND: Triglyceride/high-density lipoprotein-cholesterol (TG/HDL-C) ratio was a surrogate marker of IR; however, the relationship of TG/HDL-C with IR might vary by ethnicity. This study aims to investigate whether lipid ratios-TG/HDL-C, cholesterol/high-density lipoprotein-cholesterol (TC/HDL-C) ratio, low-density lipoprotein-cholesterol/high-density lipoprotein-cholesterol (LDL-C/HDL-C)) could be potential clinical markers of insulin resistance (IR) and β cell function and further to explore the optimal cut-offs in a Chinese population with different levels of glucose tolerance. METHODS: Four hundred seventy-nine subjects without a history of diabetes underwent a 75 g 2 h Oral Glucose Tolerance Test (OGTT). New-onset diabetes (n = 101), pre-diabetes (n = 186), and normal glucose tolerance (n = 192) were screened. IR was defined by HOMA-IR > 2.69. Based on indices (HOMA-β, early-phase disposition index [DI30], (ΔIns30/ΔGlu30)/HOMA-IR and total-phase index [DI120]) that indicated different phases of insulin secretion, the subjects were divided into two groups, and the lower group was defined as having inadequate β cell compensation. Logistic regression models and accurate estimates of the areas under receiver operating characteristic curves (AUROC) were obtained. RESULTS: In all of the subjects, TG/HDL, TC/HDL-C, LDL-C/HDL-C, and TG were significantly associated with IR. The AUROCs of TG/HDL-C and TG were 0.71 (95 % CI: 0.66-0.75) and 0.71 (95 % CI: 0.65-0.75), respectively. The optimal cut-offs of TG/HDL-C and TG for IR diagnosis were 1.11 and 1.33 mmol/L, respectively. The AUROCs of TC/HDL-C and LDL-C/HDL-C were 0.66 and 0.65, respectively, but they were not acceptable for IR diagnosis. TG/HDL-C,LDL-C/HDL-C and TG were significantly associated with HOMA-β, but AUROCs were less than 0.50; therefore, the lipid ratios could not be predictors of basal β cell dysfunction. None of the lipid ratios was associated with early-phase insulin secretion. Only TG/HDL-C and TG were significantly correlated with total-phase insulin secretion, but they also were not acceptable predictors of total-phase insulin secretion (0.60 < AUROC < 0.70). CONCLUSIONS: In a Chinese population with different levels of glucose tolerance, TG/HDL-C and TG could be the predictors of IR. The lipid ratios could not be reliable makers of β cell function in the population. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/27267043/The_triglyceride_to_high_density_lipoprotein_cholesterol__TG/HDL_C__ratio_as_a_predictor_of_insulin_resistance_but_not_of_β_cell_function_in_a_Chinese_population_with_different_glucose_tolerance_status_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-016-0270-z DB - PRIME DP - Unbound Medicine ER -