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Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study.

Abstract

Diet quality index scores on Healthy Eating Index 2010 (HEI-2010), Alternative HEI-2010, alternative Mediterranean Diet Index, and the Dietary Approaches to Stop Hypertension (DASH) index have been inversely associated with all-cause and cancer-specific death. This study assessed the association between these scores and colorectal cancer (CRC) incidence as well as CRC-specific mortality in the Women's Health Initiative Observational Study (1993-2012), a US study of postmenopausal women. During an average of 12.4 years of follow-up, there were 938 cases of CRC and 238 CRC-specific deaths. We estimated multivariate hazard ratios and 95% confidence intervals for relationships between quintiles of diet scores (from baseline food frequency questionnaires) and outcomes. HEI-2010 score (hazard ratios were 0.81, 0.77, and 0.73 with P values of 0.04, 0.01, and <0.01 for quintiles 3-5 vs. quintile 1, respectively) and DASH score (hazard ratios were 0.72, 0.74, and 0.78 with P values of <0.01, <0.01, and 0.03 for quintiles 3-5 vs. quintile 1, respectively), but not other diet scores, were associated with a lower risk of CRC in adjusted models. No diet scores were significantly associated with CRC-specific mortality. Closer adherence to HEI-2010 and DASH dietary recommendations was inversely associated with risk of CRC in this large cohort of postmenopausal women.

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  • Authors

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    Source

    American journal of epidemiology 184:1 2016 Jul 01 pg 23-32

    MeSH

    Aged
    Colorectal Neoplasms
    Diet
    Female
    Follow-Up Studies
    Humans
    Middle Aged
    Postmenopause
    Risk Factors
    Women's Health

    Pub Type(s)

    Journal Article
    Observational Study

    Language

    eng

    PubMed ID

    27267948

    Citation

    Vargas, Ashley J., et al. "Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study." American Journal of Epidemiology, vol. 184, no. 1, 2016, pp. 23-32.
    Vargas AJ, Neuhouser ML, George SM, et al. Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study. Am J Epidemiol. 2016;184(1):23-32.
    Vargas, A. J., Neuhouser, M. L., George, S. M., Thomson, C. A., Ho, G. Y., Rohan, T. E., ... Manson, J. E. (2016). Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study. American Journal of Epidemiology, 184(1), pp. 23-32. doi:10.1093/aje/kwv304.
    Vargas AJ, et al. Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study. Am J Epidemiol. 2016 Jul 1;184(1):23-32. PubMed PMID: 27267948.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study. AU - Vargas,Ashley J, AU - Neuhouser,Marian L, AU - George,Stephanie M, AU - Thomson,Cynthia A, AU - Ho,Gloria Y F, AU - Rohan,Thomas E, AU - Kato,Ikuko, AU - Nassir,Rami, AU - Hou,Lifang, AU - Manson,JoAnn E, Y1 - 2016/06/05/ PY - 2015/07/02/received PY - 2015/10/29/accepted PY - 2016/6/9/entrez PY - 2016/6/9/pubmed PY - 2019/3/21/medline KW - Alternative Healthy Eating Index KW - Alternative Mediterranean Diet KW - Dietary Approaches to Stop Hypertension KW - Healthy Eating Index KW - colorectal cancer KW - diet KW - diet quality KW - dietary patterns SP - 23 EP - 32 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 184 IS - 1 N2 - Diet quality index scores on Healthy Eating Index 2010 (HEI-2010), Alternative HEI-2010, alternative Mediterranean Diet Index, and the Dietary Approaches to Stop Hypertension (DASH) index have been inversely associated with all-cause and cancer-specific death. This study assessed the association between these scores and colorectal cancer (CRC) incidence as well as CRC-specific mortality in the Women's Health Initiative Observational Study (1993-2012), a US study of postmenopausal women. During an average of 12.4 years of follow-up, there were 938 cases of CRC and 238 CRC-specific deaths. We estimated multivariate hazard ratios and 95% confidence intervals for relationships between quintiles of diet scores (from baseline food frequency questionnaires) and outcomes. HEI-2010 score (hazard ratios were 0.81, 0.77, and 0.73 with P values of 0.04, 0.01, and <0.01 for quintiles 3-5 vs. quintile 1, respectively) and DASH score (hazard ratios were 0.72, 0.74, and 0.78 with P values of <0.01, <0.01, and 0.03 for quintiles 3-5 vs. quintile 1, respectively), but not other diet scores, were associated with a lower risk of CRC in adjusted models. No diet scores were significantly associated with CRC-specific mortality. Closer adherence to HEI-2010 and DASH dietary recommendations was inversely associated with risk of CRC in this large cohort of postmenopausal women. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/27267948/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwv304 DB - PRIME DP - Unbound Medicine ER -