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Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG).
Nutr J. 2016 06 07; 15(1):60.NJ

Abstract

Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) enforce an overwhelming social and economic burden on society. They are primarily characterized through the accumulation of modified proteins, which further trigger biological responses such as inflammation, oxidative stress, excitotoxicity and modulation of signalling pathways. In a hope for cure, these diseases have been studied extensively over the last decade to successfully develop symptom-oriented therapies. However, so far no definite cure has been found. Therefore, there is a need to identify a class of drug capable of reversing neural damage and preventing further neural death. This review therefore assesses the reliability of the neuroprotective benefits of epigallocatechin-gallate (EGCG) by shedding light on their biological, pharmacological, antioxidant and metal chelation properties, with emphasis on their ability to invoke a range of cellular mechanisms in the brain. It also discusses the possible use of nanotechnology to enhance the neuroprotective benefits of EGCG.

Authors+Show Affiliations

Department of Integrative Biology, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.Department of Biotechnology, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.Centre for Interdisciplinary Biomedical Research, Adesh University, Bathinda, Punjab, India. khan.zaved@gmail.com.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27268025

Citation

Singh, Neha Atulkumar, et al. "Potential Neuroprotective Properties of Epigallocatechin-3-gallate (EGCG)." Nutrition Journal, vol. 15, no. 1, 2016, p. 60.
Singh NA, Mandal AK, Khan ZA. Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG). Nutr J. 2016;15(1):60.
Singh, N. A., Mandal, A. K., & Khan, Z. A. (2016). Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG). Nutrition Journal, 15(1), 60. https://doi.org/10.1186/s12937-016-0179-4
Singh NA, Mandal AK, Khan ZA. Potential Neuroprotective Properties of Epigallocatechin-3-gallate (EGCG). Nutr J. 2016 06 7;15(1):60. PubMed PMID: 27268025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG). AU - Singh,Neha Atulkumar, AU - Mandal,Abul Kalam Azad, AU - Khan,Zaved Ahmed, Y1 - 2016/06/07/ PY - 2016/03/31/received PY - 2016/06/02/accepted PY - 2016/6/9/entrez PY - 2016/6/9/pubmed PY - 2017/10/17/medline KW - Antioxidant KW - Cell signalling KW - EGCG KW - Iron chelator KW - Neurodegenerative diseases KW - Neuroprotection SP - 60 EP - 60 JF - Nutrition journal JO - Nutr J VL - 15 IS - 1 N2 - Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) enforce an overwhelming social and economic burden on society. They are primarily characterized through the accumulation of modified proteins, which further trigger biological responses such as inflammation, oxidative stress, excitotoxicity and modulation of signalling pathways. In a hope for cure, these diseases have been studied extensively over the last decade to successfully develop symptom-oriented therapies. However, so far no definite cure has been found. Therefore, there is a need to identify a class of drug capable of reversing neural damage and preventing further neural death. This review therefore assesses the reliability of the neuroprotective benefits of epigallocatechin-gallate (EGCG) by shedding light on their biological, pharmacological, antioxidant and metal chelation properties, with emphasis on their ability to invoke a range of cellular mechanisms in the brain. It also discusses the possible use of nanotechnology to enhance the neuroprotective benefits of EGCG. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/27268025/Potential_neuroprotective_properties_of_epigallocatechin_3_gallate__EGCG__ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/s12937-016-0179-4 DB - PRIME DP - Unbound Medicine ER -