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[The effect of incorporation technics of water soluble macromolecular binders on the properties of fluidized-bed dried granules].
Pharmazie. 1989 Jan; 44(1):43-6.P

Abstract

Five binders characterized by particle size and dissolution rate have been studied in order to evaluate their qualification for fluidized-bed granulation. For this purpose they were applied as powder and solution, respectively. Quality parameters of the granules and tablets obtained were compared. Compared with solutions of binders the dry incorporation of the binder led to a slower growth of the granules mainly depending on the dissolution rate of the binders. Due to this fact the formulations showed a decreased strength except PVP (high dissolution rate) which causes an increased growth of the granules at the same time. A size reduction of binders with a low dissolution rate led to tablets with characteristics of strength similar to the findings when solutions of binders were used, whereas the growth of granules remained uninfluenced.

Authors+Show Affiliations

Sektion Chemie, Humboldt-Universität zu Berlin.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

2727029

Citation

Richter, M, et al. "[The Effect of Incorporation Technics of Water Soluble Macromolecular Binders On the Properties of Fluidized-bed Dried Granules]." Die Pharmazie, vol. 44, no. 1, 1989, pp. 43-6.
Richter M, Rahn HW, Voigt R. [The effect of incorporation technics of water soluble macromolecular binders on the properties of fluidized-bed dried granules]. Pharmazie. 1989;44(1):43-6.
Richter, M., Rahn, H. W., & Voigt, R. (1989). [The effect of incorporation technics of water soluble macromolecular binders on the properties of fluidized-bed dried granules]. Die Pharmazie, 44(1), 43-6.
Richter M, Rahn HW, Voigt R. [The Effect of Incorporation Technics of Water Soluble Macromolecular Binders On the Properties of Fluidized-bed Dried Granules]. Pharmazie. 1989;44(1):43-6. PubMed PMID: 2727029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of incorporation technics of water soluble macromolecular binders on the properties of fluidized-bed dried granules]. AU - Richter,M, AU - Rahn,H W, AU - Voigt,R, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 43 EP - 6 JF - Die Pharmazie JO - Pharmazie VL - 44 IS - 1 N2 - Five binders characterized by particle size and dissolution rate have been studied in order to evaluate their qualification for fluidized-bed granulation. For this purpose they were applied as powder and solution, respectively. Quality parameters of the granules and tablets obtained were compared. Compared with solutions of binders the dry incorporation of the binder led to a slower growth of the granules mainly depending on the dissolution rate of the binders. Due to this fact the formulations showed a decreased strength except PVP (high dissolution rate) which causes an increased growth of the granules at the same time. A size reduction of binders with a low dissolution rate led to tablets with characteristics of strength similar to the findings when solutions of binders were used, whereas the growth of granules remained uninfluenced. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/2727029/[The_effect_of_incorporation_technics_of_water_soluble_macromolecular_binders_on_the_properties_of_fluidized_bed_dried_granules]_ DB - PRIME DP - Unbound Medicine ER -
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