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Carotenoid intake and adipose tissue carotenoid levels in relation to prostate cancer aggressiveness among African-American and European-American men in the North Carolina-Louisiana prostate cancer project (PCaP).
Prostate. 2016 09; 76(12):1053-66.P

Abstract

BACKGROUND

Associations between carotenoid intake and prostate cancer (CaP) incidence have varied across studies. This may result from combining indolent with aggressive disease in most studies. This study examined whether carotenoid intake and adipose tissue carotenoid levels were inversely associated with CaP aggressiveness.

METHODS

Data on African-American (AA, n = 1,023) and European-American (EA, n = 1,079) men with incident CaP from North Carolina and Louisiana were analyzed. Dietary carotenoid intake was assessed using a detailed-food frequency questionnaire (FFQ), and abdominal adipose tissue samples were analyzed for carotenoid concentrations using high-performance liquid chromatography. Multivariable logistic regression was used in race-stratified analyses to calculate odds ratios (ORs) and 95% confidence intervals (95%CI) comparing high aggressive CaP with low/intermediate aggressive CaP.

RESULTS

Carotenoid intake differed significantly between AAs and EAs, which included higher intake of lycopene among EAs and higher β-cryptoxanthin intake among AAs. Comparing the highest and lowest tertiles, dietary lycopene was associated inversely with high aggressive CaP among EAs (OR = 0.55, 95%CI: 0.34-0.89, Ptrend = 0.02), while an inverse association was observed between dietary β-cryptoxanthin intake and high aggressive CaP among AAs (OR = 0.56, 95%CI: 0.36-0.87, Ptrend = 0.01). Adipose tissue α-carotene and lycopene (cis + trans) concentrations were higher among EAs than AAs, and marginally significant inverse linear trends were observed for adipose α-carotene (Ptrend = 0.07) and lycopene (Ptrend = 0.11), and CaP aggressiveness among EAs only.

CONCLUSIONS

These results suggest that diets high in lycopene and β-cryptoxanthin may protect against aggressive CaP among EAs and AAs, respectively. Differences in dietary behaviors may explain the observed racial differences in associations. Prostate 76:1053-1066, 2016. © 2016 Wiley Periodicals, Inc.

Authors+Show Affiliations

Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina.Boozman College of Public Health, Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina.Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, Tennessee.Craft Technologies, Inc., Wilson, North Carolina.School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana.Department of Urology, Roswell Park Cancer Institute, Buffalo, New York.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.Department of Urology, Roswell Park Cancer Institute, Buffalo, New York.David Geffen School of Medicine at UCLA, Los Angeles, California.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27271547

Citation

Antwi, Samuel O., et al. "Carotenoid Intake and Adipose Tissue Carotenoid Levels in Relation to Prostate Cancer Aggressiveness Among African-American and European-American Men in the North Carolina-Louisiana Prostate Cancer Project (PCaP)." The Prostate, vol. 76, no. 12, 2016, pp. 1053-66.
Antwi SO, Steck SE, Su LJ, et al. Carotenoid intake and adipose tissue carotenoid levels in relation to prostate cancer aggressiveness among African-American and European-American men in the North Carolina-Louisiana prostate cancer project (PCaP). Prostate. 2016;76(12):1053-66.
Antwi, S. O., Steck, S. E., Su, L. J., Hebert, J. R., Zhang, H., Craft, N. E., Fontham, E. T., Smith, G. J., Bensen, J. T., Mohler, J. L., & Arab, L. (2016). Carotenoid intake and adipose tissue carotenoid levels in relation to prostate cancer aggressiveness among African-American and European-American men in the North Carolina-Louisiana prostate cancer project (PCaP). The Prostate, 76(12), 1053-66. https://doi.org/10.1002/pros.23189
Antwi SO, et al. Carotenoid Intake and Adipose Tissue Carotenoid Levels in Relation to Prostate Cancer Aggressiveness Among African-American and European-American Men in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Prostate. 2016;76(12):1053-66. PubMed PMID: 27271547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotenoid intake and adipose tissue carotenoid levels in relation to prostate cancer aggressiveness among African-American and European-American men in the North Carolina-Louisiana prostate cancer project (PCaP). AU - Antwi,Samuel O, AU - Steck,Susan E, AU - Su,L Joseph, AU - Hebert,James R, AU - Zhang,Hongmei, AU - Craft,Neal E, AU - Fontham,Elizabeth T H, AU - Smith,Gary J, AU - Bensen,Jeannette T, AU - Mohler,James L, AU - Arab,Lenore, Y1 - 2016/06/08/ PY - 2016/02/05/received PY - 2016/03/29/accepted PY - 2016/6/9/entrez PY - 2016/6/9/pubmed PY - 2017/7/14/medline KW - adipose tissue KW - carotenoids KW - lutein KW - lycopene KW - nutritional biomarkers KW - prostate cancer KW - supplements KW - zeaxanthin KW - α−carotene KW - β−carotene KW - β−cryptoxanthin SP - 1053 EP - 66 JF - The Prostate JO - Prostate VL - 76 IS - 12 N2 - BACKGROUND: Associations between carotenoid intake and prostate cancer (CaP) incidence have varied across studies. This may result from combining indolent with aggressive disease in most studies. This study examined whether carotenoid intake and adipose tissue carotenoid levels were inversely associated with CaP aggressiveness. METHODS: Data on African-American (AA, n = 1,023) and European-American (EA, n = 1,079) men with incident CaP from North Carolina and Louisiana were analyzed. Dietary carotenoid intake was assessed using a detailed-food frequency questionnaire (FFQ), and abdominal adipose tissue samples were analyzed for carotenoid concentrations using high-performance liquid chromatography. Multivariable logistic regression was used in race-stratified analyses to calculate odds ratios (ORs) and 95% confidence intervals (95%CI) comparing high aggressive CaP with low/intermediate aggressive CaP. RESULTS: Carotenoid intake differed significantly between AAs and EAs, which included higher intake of lycopene among EAs and higher β-cryptoxanthin intake among AAs. Comparing the highest and lowest tertiles, dietary lycopene was associated inversely with high aggressive CaP among EAs (OR = 0.55, 95%CI: 0.34-0.89, Ptrend = 0.02), while an inverse association was observed between dietary β-cryptoxanthin intake and high aggressive CaP among AAs (OR = 0.56, 95%CI: 0.36-0.87, Ptrend = 0.01). Adipose tissue α-carotene and lycopene (cis + trans) concentrations were higher among EAs than AAs, and marginally significant inverse linear trends were observed for adipose α-carotene (Ptrend = 0.07) and lycopene (Ptrend = 0.11), and CaP aggressiveness among EAs only. CONCLUSIONS: These results suggest that diets high in lycopene and β-cryptoxanthin may protect against aggressive CaP among EAs and AAs, respectively. Differences in dietary behaviors may explain the observed racial differences in associations. Prostate 76:1053-1066, 2016. © 2016 Wiley Periodicals, Inc. SN - 1097-0045 UR - https://www.unboundmedicine.com/medline/citation/27271547/Carotenoid_intake_and_adipose_tissue_carotenoid_levels_in_relation_to_prostate_cancer_aggressiveness_among_African_American_and_European_American_men_in_the_North_Carolina_Louisiana_prostate_cancer_project__PCaP__ L2 - https://doi.org/10.1002/pros.23189 DB - PRIME DP - Unbound Medicine ER -