Tags

Type your tag names separated by a space and hit enter

Cohort study of electronic cigarette use: effectiveness and safety at 24 months.
Tob Control. 2017 05; 26(3):284-292.TC

Abstract

OBJECTIVE

To evaluate the safety and effectiveness of e-cigarettes, by comparing users of only e-cigarettes, smokers of only tobacco cigarettes and dual users.

DESIGN

Prospective cohort study. We update previous 12-month findings and report the results of the 24-month follow-up.

DATA SOURCES

Direct contact and questionnaires by phone or via internet.

METHODS

Adults (30-75 years) were classified as: (1) tobacco smokers, if they smoked ≥1 tobacco cigarette/day, (2) e-cigarette users, if they inhaled ≥50 puffs/week of any type of e-cigarette and (3) dual users, if they smoked tobacco cigarettes and also used e-cigarettes. Carbon monoxide levels were tested in 50% of those declaring tobacco smoking abstinence. Hospital discharge data were used to validate possibly related serious adverse events in 46.0% of the sample.

MAIN OUTCOME MEASURES

Sustained abstinence from tobacco cigarettes and/or e-cigarettes after 24 months, the difference in the number of tobacco cigarettes smoked daily between baseline and 24 months, possibly related serious adverse events.

RESULTS

Data at 24 months were available for 229 e-cigarette users, 480 tobacco smokers and 223 dual users (overall response rate 68.8%). Of the e-cigarette users, 61.1% remained abstinent from tobacco (while 23.1% and 26.0% of tobacco-only smokers and dual users achieved tobacco abstinence). The rate (18.8%) of stopping use of either product (tobacco and/or e-cigarettes) was not higher for e-cigarette users compared with tobacco smokers or dual users. Self-rated health and adverse events were similar between all groups. Among those continuing to smoke, there were no differences in the proportion of participants reducing tobacco cigarette consumption by 50% or more, the average daily number of cigarettes and the average self-rated health by baseline group. Most dual users at baseline abandoned e-cigarettes and continued to smoke tobacco. Those who continued dual using or converted from tobacco smoking to dual use during follow-up experienced significant improvements in the 3 outcomes compared with those who continued or switched to only smoking tobacco (p<0.001).

CONCLUSIONS

E-cigarette use alone might support tobacco quitters remaining abstinent from smoking. However, dual use did not improve the likelihood of quitting tobacco or e-cigarette use, but may be helpful to reduce tobacco consumption. Adverse event data were scarce and must be considered preliminary.

TRIAL REGISTRATION NUMBER

NCT01785537.

Authors+Show Affiliations

Department of Medicine and Aging Sciences, University of Chieti, Chieti, Italy. Local Health Unit of Pescara, Pescara, Italy. "University G. d'Annunzio" Foundation, Chieti, Italy. Regional Healthcare Agency of Abruzzo, Pescara, Italy.Department of Medicine and Aging Sciences, University of Chieti, Chieti, Italy. Local Health Unit of Pescara, Pescara, Italy.Department "G. F. Ingrassia"-Hygiene and Public Health, University of Catania, Catania, Italy.Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.Department of Public Health Sciences, University of Turin, Turin, Italy.Italian National Institute of Health, Rome, Italy. Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Largo Francesco Vito, Roma, Italy.Department of Public Health and Infectious Diseases, Sapienza University of Rome, Roma, Italy.Department of Public Health and Infectious Diseases, Sapienza University of Rome, Roma, Italy.Department "G. F. Ingrassia"-Hygiene and Public Health, University of Catania, Catania, Italy.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27272748

Citation

Manzoli, Lamberto, et al. "Cohort Study of Electronic Cigarette Use: Effectiveness and Safety at 24 Months." Tobacco Control, vol. 26, no. 3, 2017, pp. 284-292.
Manzoli L, Flacco ME, Ferrante M, et al. Cohort study of electronic cigarette use: effectiveness and safety at 24 months. Tob Control. 2017;26(3):284-292.
Manzoli, L., Flacco, M. E., Ferrante, M., La Vecchia, C., Siliquini, R., Ricciardi, W., Marzuillo, C., Villari, P., & Fiore, M. (2017). Cohort study of electronic cigarette use: effectiveness and safety at 24 months. Tobacco Control, 26(3), 284-292. https://doi.org/10.1136/tobaccocontrol-2015-052822
Manzoli L, et al. Cohort Study of Electronic Cigarette Use: Effectiveness and Safety at 24 Months. Tob Control. 2017;26(3):284-292. PubMed PMID: 27272748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cohort study of electronic cigarette use: effectiveness and safety at 24 months. AU - Manzoli,Lamberto, AU - Flacco,Maria Elena, AU - Ferrante,Margherita, AU - La Vecchia,Carlo, AU - Siliquini,Roberta, AU - Ricciardi,Walter, AU - Marzuillo,Carolina, AU - Villari,Paolo, AU - Fiore,Maria, AU - ,, Y1 - 2016/06/06/ PY - 2015/11/11/received PY - 2016/04/19/accepted PY - 2016/6/9/pubmed PY - 2017/7/18/medline PY - 2016/6/9/entrez KW - Cessation KW - Electronic nicotine delivery devices KW - Harm Reduction SP - 284 EP - 292 JF - Tobacco control JO - Tob Control VL - 26 IS - 3 N2 - OBJECTIVE: To evaluate the safety and effectiveness of e-cigarettes, by comparing users of only e-cigarettes, smokers of only tobacco cigarettes and dual users. DESIGN: Prospective cohort study. We update previous 12-month findings and report the results of the 24-month follow-up. DATA SOURCES: Direct contact and questionnaires by phone or via internet. METHODS: Adults (30-75 years) were classified as: (1) tobacco smokers, if they smoked ≥1 tobacco cigarette/day, (2) e-cigarette users, if they inhaled ≥50 puffs/week of any type of e-cigarette and (3) dual users, if they smoked tobacco cigarettes and also used e-cigarettes. Carbon monoxide levels were tested in 50% of those declaring tobacco smoking abstinence. Hospital discharge data were used to validate possibly related serious adverse events in 46.0% of the sample. MAIN OUTCOME MEASURES: Sustained abstinence from tobacco cigarettes and/or e-cigarettes after 24 months, the difference in the number of tobacco cigarettes smoked daily between baseline and 24 months, possibly related serious adverse events. RESULTS: Data at 24 months were available for 229 e-cigarette users, 480 tobacco smokers and 223 dual users (overall response rate 68.8%). Of the e-cigarette users, 61.1% remained abstinent from tobacco (while 23.1% and 26.0% of tobacco-only smokers and dual users achieved tobacco abstinence). The rate (18.8%) of stopping use of either product (tobacco and/or e-cigarettes) was not higher for e-cigarette users compared with tobacco smokers or dual users. Self-rated health and adverse events were similar between all groups. Among those continuing to smoke, there were no differences in the proportion of participants reducing tobacco cigarette consumption by 50% or more, the average daily number of cigarettes and the average self-rated health by baseline group. Most dual users at baseline abandoned e-cigarettes and continued to smoke tobacco. Those who continued dual using or converted from tobacco smoking to dual use during follow-up experienced significant improvements in the 3 outcomes compared with those who continued or switched to only smoking tobacco (p<0.001). CONCLUSIONS: E-cigarette use alone might support tobacco quitters remaining abstinent from smoking. However, dual use did not improve the likelihood of quitting tobacco or e-cigarette use, but may be helpful to reduce tobacco consumption. Adverse event data were scarce and must be considered preliminary. TRIAL REGISTRATION NUMBER: NCT01785537. SN - 1468-3318 UR - https://www.unboundmedicine.com/medline/citation/27272748/Cohort_study_of_electronic_cigarette_use:_effectiveness_and_safety_at_24_months_ L2 - https://tobaccocontrol.bmj.com/lookup/pmidlookup?view=long&amp;pmid=27272748 DB - PRIME DP - Unbound Medicine ER -