Pd-Catalyzed C-H Alkylation of Arenes Using PyrDipSi, a Transformable and Removable Silicon-Tethered Directing Group.Chemistry. 2016 Aug 01; 22(32):11201-4.C
Abstract
An efficient Pd-catalyzed ortho-C-H alkylation reaction of arenes using a transformable and removable Si-tethered pyridyldiisopropylsilyl (PyrDipSi) directing group has been developed. In addition, the PyrDipSi directing group allows for an efficient sequential double-fold C-H alkylation/oxygenation of arenes to produce meta-alkylated phenols. This directing group can easily be removed or converted into valuable functionalities, such as aryl, iodo, boronic ester, or phenol.
Links
Pub Type(s)
Journal Article
Language
eng
PubMed ID
27272930
Citation
Sarkar, Dhruba, and Vladimir Gevorgyan. "Pd-Catalyzed C-H Alkylation of Arenes Using PyrDipSi, a Transformable and Removable Silicon-Tethered Directing Group." Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 22, no. 32, 2016, pp. 11201-4.
Sarkar D, Gevorgyan V. Pd-Catalyzed C-H Alkylation of Arenes Using PyrDipSi, a Transformable and Removable Silicon-Tethered Directing Group. Chemistry. 2016;22(32):11201-4.
Sarkar, D., & Gevorgyan, V. (2016). Pd-Catalyzed C-H Alkylation of Arenes Using PyrDipSi, a Transformable and Removable Silicon-Tethered Directing Group. Chemistry (Weinheim an Der Bergstrasse, Germany), 22(32), 11201-4. https://doi.org/10.1002/chem.201602513
Sarkar D, Gevorgyan V. Pd-Catalyzed C-H Alkylation of Arenes Using PyrDipSi, a Transformable and Removable Silicon-Tethered Directing Group. Chemistry. 2016 Aug 1;22(32):11201-4. PubMed PMID: 27272930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Pd-Catalyzed C-H Alkylation of Arenes Using PyrDipSi, a Transformable and Removable Silicon-Tethered Directing Group.
AU - Sarkar,Dhruba,
AU - Gevorgyan,Vladimir,
Y1 - 2016/07/04/
PY - 2016/05/26/received
PY - 2016/6/9/entrez
PY - 2016/6/9/pubmed
PY - 2016/6/9/medline
KW - C−H alkylation
KW - catalysis
KW - directing group
KW - palladium
KW - silicon
SP - 11201
EP - 4
JF - Chemistry (Weinheim an der Bergstrasse, Germany)
JO - Chemistry
VL - 22
IS - 32
N2 - An efficient Pd-catalyzed ortho-C-H alkylation reaction of arenes using a transformable and removable Si-tethered pyridyldiisopropylsilyl (PyrDipSi) directing group has been developed. In addition, the PyrDipSi directing group allows for an efficient sequential double-fold C-H alkylation/oxygenation of arenes to produce meta-alkylated phenols. This directing group can easily be removed or converted into valuable functionalities, such as aryl, iodo, boronic ester, or phenol.
SN - 1521-3765
UR - https://www.unboundmedicine.com/medline/citation/27272930/Pd_Catalyzed_C_H_Alkylation_of_Arenes_Using_PyrDipSi_a_Transformable_and_Removable_Silicon_Tethered_Directing_Group_
DB - PRIME
DP - Unbound Medicine
ER -
