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Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts.
Arthritis Care Res (Hoboken) 2017; 69(3):384-392AC

Abstract

OBJECTIVE

Moderate alcohol consumption has antiinflammatory properties and is associated with reduced cardiovascular disease and rheumatoid arthritis risks. We investigated the association between alcohol consumption and systemic lupus erythematosus (SLE) risk among women followed in the Nurses' Health Study (NHS) cohorts.

METHODS

We conducted a prospective cohort analysis among 204,055 women in NHS (1980-2012) and NHSII (1989-2011) who were free of connective tissue disease and provided alcohol information at baseline. Alcohol consumption was assessed using a semiquantitative food frequency questionnaire every 2-4 years. We validated incident SLE through medical record review after self-report. Cox proportional hazards models estimated hazard ratios (HRs) for SLE based on cumulative average alcohol intake, adjusting for potential confounders. Results were meta-analyzed using DerSimonian and Laird random-effects models. We further investigated SLE risk associated with wine, beer, and liquor intake.

RESULTS

We identified 125 incident SLE cases in NHS and 119 in NHSII. Mean ± SD age at SLE diagnosis was 55.8 ± 9.5 years in NHS and 43.4 ± 7.7 years in NHSII. Compared to no alcohol intake, the meta-analyzed multivariable HR for cumulative alcohol consumption ≥5 gm/day was 0.61 (95% confidence interval [95% CI] 0.41-0.89). When limiting alcohol exposure to >4 years prior to SLE diagnosis, the multivariable HR was similar: 0.61 (95% CI 0.41-0.91). Women who drank ≥2 servings/week of wine had significantly decreased SLE risk (HR 0.65, 95% CI 0.45-0.96) compared to women who did not drink wine.

CONCLUSION

In these large prospective cohorts, we demonstrated an inverse association between moderate alcohol consumption (≥5 grams or 0.5 drink/day) and SLE risk in women.

Authors+Show Affiliations

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27273851

Citation

Barbhaiya, Medha, et al. "Influence of Alcohol Consumption On the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts." Arthritis Care & Research, vol. 69, no. 3, 2017, pp. 384-392.
Barbhaiya M, Lu B, Sparks JA, et al. Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts. Arthritis Care Res (Hoboken). 2017;69(3):384-392.
Barbhaiya, M., Lu, B., Sparks, J. A., Malspeis, S., Chang, S. C., Karlson, E. W., & Costenbader, K. H. (2017). Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts. Arthritis Care & Research, 69(3), pp. 384-392. doi:10.1002/acr.22945.
Barbhaiya M, et al. Influence of Alcohol Consumption On the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts. Arthritis Care Res (Hoboken). 2017;69(3):384-392. PubMed PMID: 27273851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts. AU - Barbhaiya,Medha, AU - Lu,Bing, AU - Sparks,Jeffrey A, AU - Malspeis,Susan, AU - Chang,Shun-Chiao, AU - Karlson,Elizabeth W, AU - Costenbader,Karen H, PY - 2015/12/10/received PY - 2016/04/08/revised PY - 2016/05/24/accepted PY - 2016/6/9/pubmed PY - 2017/7/14/medline PY - 2016/6/9/entrez SP - 384 EP - 392 JF - Arthritis care & research JO - Arthritis Care Res (Hoboken) VL - 69 IS - 3 N2 - OBJECTIVE: Moderate alcohol consumption has antiinflammatory properties and is associated with reduced cardiovascular disease and rheumatoid arthritis risks. We investigated the association between alcohol consumption and systemic lupus erythematosus (SLE) risk among women followed in the Nurses' Health Study (NHS) cohorts. METHODS: We conducted a prospective cohort analysis among 204,055 women in NHS (1980-2012) and NHSII (1989-2011) who were free of connective tissue disease and provided alcohol information at baseline. Alcohol consumption was assessed using a semiquantitative food frequency questionnaire every 2-4 years. We validated incident SLE through medical record review after self-report. Cox proportional hazards models estimated hazard ratios (HRs) for SLE based on cumulative average alcohol intake, adjusting for potential confounders. Results were meta-analyzed using DerSimonian and Laird random-effects models. We further investigated SLE risk associated with wine, beer, and liquor intake. RESULTS: We identified 125 incident SLE cases in NHS and 119 in NHSII. Mean ± SD age at SLE diagnosis was 55.8 ± 9.5 years in NHS and 43.4 ± 7.7 years in NHSII. Compared to no alcohol intake, the meta-analyzed multivariable HR for cumulative alcohol consumption ≥5 gm/day was 0.61 (95% confidence interval [95% CI] 0.41-0.89). When limiting alcohol exposure to >4 years prior to SLE diagnosis, the multivariable HR was similar: 0.61 (95% CI 0.41-0.91). Women who drank ≥2 servings/week of wine had significantly decreased SLE risk (HR 0.65, 95% CI 0.45-0.96) compared to women who did not drink wine. CONCLUSION: In these large prospective cohorts, we demonstrated an inverse association between moderate alcohol consumption (≥5 grams or 0.5 drink/day) and SLE risk in women. SN - 2151-4658 UR - https://www.unboundmedicine.com/medline/citation/27273851/Influence_of_Alcohol_Consumption_on_the_Risk_of_Systemic_Lupus_Erythematosus_Among_Women_in_the_Nurses'_Health_Study_Cohorts_ L2 - https://doi.org/10.1002/acr.22945 DB - PRIME DP - Unbound Medicine ER -