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Influenza Vaccination Reduces Hospitalization for Heart Failure in Elderly Patients with Chronic Kidney Disease: A Population-Based Cohort Study.
Acta Cardiol Sin 2016; 32(3):290-8AC

Abstract

BACKGROUND

Elderly patients with chronic kidney disease (CKD) are at a higher risk of hospitalization for cardiovascular diseases (CVD). Previous studies have reported the beneficial effects of the influenza vaccine in patients with CVD. However, the effects of influenza vaccination on the reduction of hospitalizations for heart failure (HF) in elderly patients with CKD remain unclear.

METHODS

This cohort study comprised elderly patients (≥ 55 years of age) with a recorded diagnosis of CKD (n = 4406) between January 1, 1999 and December 31, 2008. Each patient was followed-up until the end of 2008. The hazard ratio (HR) and 95% confidence interval (CI) for the association between the influenza vaccination and the first HF hospitalization were analyzed. In addition, the patients were categorized into four groups based on their vaccination status (unvaccinated and total number of vaccinations: 1, 2-3, and ≥ 4).

RESULTS

We found that elderly patients with CKD receiving influenza vaccination exhibited a lower risk of HF hospitalization (adjusted HR, 0.31; 95% CI, 0.26-0.39, p < 0.001). The protective effects of influenza vaccination remained consistent regardless of the age group (55-64, 65-74, ≥ 75), sex, and influenza seasonality. When the patients were stratified according to the total number of vaccinations, the adjusted HRs for HF hospitalization were 0.60 (0.47-0.77), 0.30 (0.23-0.41), and 0.10 (0.06-0.16) for patients who received 1, 2-3, and ≥ 4 vaccinations during the follow-up period, respectively.

CONCLUSIONS

The results revealed that elderly patients with CKD receiving annual influenza vaccination are at a lower risk of HF hospitalization.

Authors+Show Affiliations

Center of Excellence for Cancer Research, Taipei Medical University; ; Cancer Center, Taipei Medical University - Wan Fang Hospital;Cancer Center, Taipei Medical University - Wan Fang Hospital;Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei; ; Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei; ; Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27274169

Citation

Fang, Yu-Ann, et al. "Influenza Vaccination Reduces Hospitalization for Heart Failure in Elderly Patients With Chronic Kidney Disease: a Population-Based Cohort Study." Acta Cardiologica Sinica, vol. 32, no. 3, 2016, pp. 290-8.
Fang YA, Chen CI, Liu JC, et al. Influenza Vaccination Reduces Hospitalization for Heart Failure in Elderly Patients with Chronic Kidney Disease: A Population-Based Cohort Study. Acta Cardiol Sin. 2016;32(3):290-8.
Fang, Y. A., Chen, C. I., Liu, J. C., & Sung, L. C. (2016). Influenza Vaccination Reduces Hospitalization for Heart Failure in Elderly Patients with Chronic Kidney Disease: A Population-Based Cohort Study. Acta Cardiologica Sinica, 32(3), pp. 290-8.
Fang YA, et al. Influenza Vaccination Reduces Hospitalization for Heart Failure in Elderly Patients With Chronic Kidney Disease: a Population-Based Cohort Study. Acta Cardiol Sin. 2016;32(3):290-8. PubMed PMID: 27274169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza Vaccination Reduces Hospitalization for Heart Failure in Elderly Patients with Chronic Kidney Disease: A Population-Based Cohort Study. AU - Fang,Yu-Ann, AU - Chen,Chang-I, AU - Liu,Ju-Chi, AU - Sung,Li-Chin, PY - 2016/6/9/entrez PY - 2016/6/9/pubmed PY - 2016/6/9/medline KW - Chronic kidney disease KW - Cohort studies KW - Heart failure KW - Influenza vaccines SP - 290 EP - 8 JF - Acta Cardiologica Sinica JO - Acta Cardiol Sin VL - 32 IS - 3 N2 - BACKGROUND: Elderly patients with chronic kidney disease (CKD) are at a higher risk of hospitalization for cardiovascular diseases (CVD). Previous studies have reported the beneficial effects of the influenza vaccine in patients with CVD. However, the effects of influenza vaccination on the reduction of hospitalizations for heart failure (HF) in elderly patients with CKD remain unclear. METHODS: This cohort study comprised elderly patients (≥ 55 years of age) with a recorded diagnosis of CKD (n = 4406) between January 1, 1999 and December 31, 2008. Each patient was followed-up until the end of 2008. The hazard ratio (HR) and 95% confidence interval (CI) for the association between the influenza vaccination and the first HF hospitalization were analyzed. In addition, the patients were categorized into four groups based on their vaccination status (unvaccinated and total number of vaccinations: 1, 2-3, and ≥ 4). RESULTS: We found that elderly patients with CKD receiving influenza vaccination exhibited a lower risk of HF hospitalization (adjusted HR, 0.31; 95% CI, 0.26-0.39, p < 0.001). The protective effects of influenza vaccination remained consistent regardless of the age group (55-64, 65-74, ≥ 75), sex, and influenza seasonality. When the patients were stratified according to the total number of vaccinations, the adjusted HRs for HF hospitalization were 0.60 (0.47-0.77), 0.30 (0.23-0.41), and 0.10 (0.06-0.16) for patients who received 1, 2-3, and ≥ 4 vaccinations during the follow-up period, respectively. CONCLUSIONS: The results revealed that elderly patients with CKD receiving annual influenza vaccination are at a lower risk of HF hospitalization. SN - 1011-6842 UR - https://www.unboundmedicine.com/medline/citation/27274169/Influenza_Vaccination_Reduces_Hospitalization_for_Heart_Failure_in_Elderly_Patients_with_Chronic_Kidney_Disease:_A_Population_Based_Cohort_Study_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27274169/ DB - PRIME DP - Unbound Medicine ER -