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Effects of previous episodes of influenza and vaccination in preventing laboratory-confirmed influenza in Navarre, Spain, 2013/14 season.
Euro Surveill. 2016 Jun 02; 20(22)ES

Abstract

We estimated whether previous episodes of influenza and trivalent influenza vaccination prevented laboratory-confirmed influenza in Navarre, Spain, in season 2013/14. Patients with medically-attended influenza-like illness (MA-ILI) in hospitals (n = 645) and primary healthcare (n = 525) were included. We compared 589 influenza cases and 581 negative controls. MA-ILI related to a specific virus subtype in the previous five seasons was defined as a laboratory-confirmed influenza infection with the same virus subtype or MA-ILI during weeks when more than 25% of swabs were positive for this subtype. Persons with previous MA-ILI had 30% (95% confidence interval (CI): -7 to 54) lower risk of MA-ILI, and those with previous MA-ILI related to A(H1N1)pdm09 or A(H3N2) virus, had a, respectively, 63% (95% CI: 16-84) and 65% (95% CI: 13-86) lower risk of new laboratory-confirmed influenza by the same subtype. Overall adjusted vaccine effectiveness in preventing laboratory-confirmed influenza was 31% (95% CI: 5-50): 45% (95% CI: 12-65) for A(H1N1)pdm09 and 20% (95% CI: -16 to 44) for A(H3N2). While a previous influenza episode induced high protection only against the same virus subtype, influenza vaccination provided low to moderate protection against all circulating subtypes. Influenza vaccine remains the main preventive option for high-risk populations.

Authors+Show Affiliations

Instituto de Salud Pública de Navarra, IdiSNA - Navarra Institute for Health Research, Pamplona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27277013

Citation

Castilla, Jesús, et al. "Effects of Previous Episodes of Influenza and Vaccination in Preventing Laboratory-confirmed Influenza in Navarre, Spain, 2013/14 Season." Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, vol. 20, no. 22, 2016.
Castilla J, Navascués A, Fernández-Alonso M, et al. Effects of previous episodes of influenza and vaccination in preventing laboratory-confirmed influenza in Navarre, Spain, 2013/14 season. Euro Surveill. 2016;20(22).
Castilla, J., Navascués, A., Fernández-Alonso, M., Reina, G., Albéniz, E., Pozo, F., Álvarez, N., Martínez-Baz, I., Guevara, M., García-Cenoz, M., Irisarri, F., Casado, I., & Ezpeleta, C. (2016). Effects of previous episodes of influenza and vaccination in preventing laboratory-confirmed influenza in Navarre, Spain, 2013/14 season. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 20(22). https://doi.org/10.2807/1560-7917.ES.2016.21.22.30243
Castilla J, et al. Effects of Previous Episodes of Influenza and Vaccination in Preventing Laboratory-confirmed Influenza in Navarre, Spain, 2013/14 Season. Euro Surveill. 2016 Jun 2;20(22) PubMed PMID: 27277013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of previous episodes of influenza and vaccination in preventing laboratory-confirmed influenza in Navarre, Spain, 2013/14 season. AU - Castilla,Jesús, AU - Navascués,Ana, AU - Fernández-Alonso,Mirian, AU - Reina,Gabriel, AU - Albéniz,Esther, AU - Pozo,Francisco, AU - Álvarez,Nerea, AU - Martínez-Baz,Iván, AU - Guevara,Marcela, AU - García-Cenoz,Manuel, AU - Irisarri,Fátima, AU - Casado,Itziar, AU - Ezpeleta,Carmen, AU - ,, PY - 2015/07/27/received PY - 2016/02/25/accepted PY - 2016/6/10/entrez PY - 2016/6/10/pubmed PY - 2017/2/28/medline KW - Influenza KW - case control study KW - influenza vaccine KW - influenza-like illness KW - vaccine effectiveness JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JO - Euro Surveill VL - 20 IS - 22 N2 - We estimated whether previous episodes of influenza and trivalent influenza vaccination prevented laboratory-confirmed influenza in Navarre, Spain, in season 2013/14. Patients with medically-attended influenza-like illness (MA-ILI) in hospitals (n = 645) and primary healthcare (n = 525) were included. We compared 589 influenza cases and 581 negative controls. MA-ILI related to a specific virus subtype in the previous five seasons was defined as a laboratory-confirmed influenza infection with the same virus subtype or MA-ILI during weeks when more than 25% of swabs were positive for this subtype. Persons with previous MA-ILI had 30% (95% confidence interval (CI): -7 to 54) lower risk of MA-ILI, and those with previous MA-ILI related to A(H1N1)pdm09 or A(H3N2) virus, had a, respectively, 63% (95% CI: 16-84) and 65% (95% CI: 13-86) lower risk of new laboratory-confirmed influenza by the same subtype. Overall adjusted vaccine effectiveness in preventing laboratory-confirmed influenza was 31% (95% CI: 5-50): 45% (95% CI: 12-65) for A(H1N1)pdm09 and 20% (95% CI: -16 to 44) for A(H3N2). While a previous influenza episode induced high protection only against the same virus subtype, influenza vaccination provided low to moderate protection against all circulating subtypes. Influenza vaccine remains the main preventive option for high-risk populations. SN - 1560-7917 UR - https://www.unboundmedicine.com/medline/citation/27277013/Effects_of_previous_episodes_of_influenza_and_vaccination_in_preventing_laboratory_confirmed_influenza_in_Navarre_Spain_2013/14_season_ L2 - http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=22488 DB - PRIME DP - Unbound Medicine ER -