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Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection.
Parasitology. 2016 09; 143(10):1243-51.P

Abstract

This study investigated comparatively the pathogenicity of experimental infection of mice and guinea pigs, with Angiostrongylus mackerrasae and the closely related species A. cantonensis. Time course analyses showed that A. mackerrasae causes eosinophilic meningitis in these hosts, which suggests that the species has the potential to cause meningitis in humans and domestic animals. Both A. mackerrasae and the genetically similar A. cantonensis caused eosinophilic meningitis in mice at two time points of 14 and 21 days post infection (dpi). The brain lesions in mice infected with A. mackerrasae were more granulomatous in nature and the parasites were more likely to appear degenerate compared with lesions caused by A. cantonensis. This may indicate that the mouse immune system eliminates A. mackerrasae infection more effectively. The immunologic responses of mice infected with the two Angiostrongylus species was compared by assessing ex vivo stimulated spleen derived T cells and cytokines including interferon-gamma, interleukin 4 and interleukin 17 on 14 and 21 dpi. The results were similar for mice infected with A. cantonensis and A. mackerrasae. Serum from the infected animals with either A. cantonensis or A. mackerrasae recognized total soluble antigen of A. cantonensis female worms on Western blot.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Aghazadeh M
The University of Queensland,School of Veterinary Science,Gatton,Queensland 4343,Australia.
Harvie MC
QIMR Berghofer Medical Research Institute,Brisbane,Queensland 4006,Australia.
Owen HC
The University of Queensland,School of Veterinary Science,Gatton,Queensland 4343,Australia.
Veríssimo C
Laboratório de BiologiaParasitária e Parasitologia Molecular,Pontifícia Universidade Católica do Rio Grande do Sul,Porto Alegre,Brazil.
Aland KV
Queensland Museum and Sciencentre,Queensland 4101,Australia.
Reid SA
The University of Queensland,School of Public Health,Herston,QLD 4006,Australia.
Traub RJ
Faculty of Veterinary and Agricultural Sciences,University of Melbourne,Parkville,Victoria 3052,Australia.
McMANUS DP
QIMR Berghofer Medical Research Institute,Brisbane,Queensland 4006,Australia.
McCARTHY JS
QIMR Berghofer Medical Research Institute,Brisbane,Queensland 4006,Australia.
Jones MK
The University of Queensland,School of Veterinary Science,Gatton,Queensland 4343,Australia.

MeSH

AngiostrongylusAngiostrongylus cantonensisAnimalsAntigens, HelminthBrainCytokinesDisease Models, AnimalEosinophiliaFemaleGuinea PigsHumansInterferon-gammaMeningitisMiceSpleenStrongylida InfectionsT-Lymphocytes

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27278827

Citation

Aghazadeh, Mahdis, et al. "Comparative Pathogenesis of Eosinophilic Meningitis Caused By Angiostrongylus Mackerrasae and Angiostrongylus Cantonensis in Murine and Guinea Pig Models of Human Infection." Parasitology, vol. 143, no. 10, 2016, pp. 1243-51.
Aghazadeh M, Harvie MC, Owen HC, et al. Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection. Parasitology. 2016;143(10):1243-51.
Aghazadeh, M., Harvie, M. C., Owen, H. C., Veríssimo, C., Aland, K. V., Reid, S. A., Traub, R. J., McMANUS, D. P., McCARTHY, J. S., & Jones, M. K. (2016). Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection. Parasitology, 143(10), 1243-51. https://doi.org/10.1017/S003118201600069X
Aghazadeh M, et al. Comparative Pathogenesis of Eosinophilic Meningitis Caused By Angiostrongylus Mackerrasae and Angiostrongylus Cantonensis in Murine and Guinea Pig Models of Human Infection. Parasitology. 2016;143(10):1243-51. PubMed PMID: 27278827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection. AU - Aghazadeh,Mahdis, AU - Harvie,Marina C, AU - Owen,Helen C, AU - Veríssimo,Carolina, AU - Aland,Kieran V, AU - Reid,Simon A, AU - Traub,Rebecca J, AU - McMANUS,Donald P, AU - McCARTHY,James S, AU - Jones,Malcolm K, Y1 - 2016/06/09/ PY - 2016/6/10/entrez PY - 2016/6/10/pubmed PY - 2017/9/16/medline KW - Angiostrongylus cantonensis KW - Angiostrongylus mackerrasae KW - Rattus fuscipes KW - angiostrongyliasis KW - eosinophilic meningitis KW - rat lungworm SP - 1243 EP - 51 JF - Parasitology JO - Parasitology VL - 143 IS - 10 N2 - This study investigated comparatively the pathogenicity of experimental infection of mice and guinea pigs, with Angiostrongylus mackerrasae and the closely related species A. cantonensis. Time course analyses showed that A. mackerrasae causes eosinophilic meningitis in these hosts, which suggests that the species has the potential to cause meningitis in humans and domestic animals. Both A. mackerrasae and the genetically similar A. cantonensis caused eosinophilic meningitis in mice at two time points of 14 and 21 days post infection (dpi). The brain lesions in mice infected with A. mackerrasae were more granulomatous in nature and the parasites were more likely to appear degenerate compared with lesions caused by A. cantonensis. This may indicate that the mouse immune system eliminates A. mackerrasae infection more effectively. The immunologic responses of mice infected with the two Angiostrongylus species was compared by assessing ex vivo stimulated spleen derived T cells and cytokines including interferon-gamma, interleukin 4 and interleukin 17 on 14 and 21 dpi. The results were similar for mice infected with A. cantonensis and A. mackerrasae. Serum from the infected animals with either A. cantonensis or A. mackerrasae recognized total soluble antigen of A. cantonensis female worms on Western blot. SN - 1469-8161 UR - https://www.unboundmedicine.com/medline/citation/27278827/Comparative_pathogenesis_of_eosinophilic_meningitis_caused_by_Angiostrongylus_mackerrasae_and_Angiostrongylus_cantonensis_in_murine_and_guinea_pig_models_of_human_infection_ DB - PRIME DP - Unbound Medicine ER -