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[Analysis of the Cochrane Review: Antihistamines for the Common Cold. Cochrane Database Syst Rev. 2015;11:CD009345].

Abstract

The common cold is an acute, self-limiting inflammation of the mucosa of the upper airways, which may involve one or all the sinuses, nasopharynx, oropharynx and larynx. It is common to have at least one episode per year. Common cold symptoms, which may include sore throat, sneezing, nasal congestion, runny nose, headache, malaise and mild fever usually disappear within a few days without treatment. The causative agent of most colds is rhinovirus. Although not associated with mortality, common cold is associated with significant morbidity. There is no vaccine or cure for common cold and, therefore, their treatment is centered on relieving the symptoms. This Cochrane review aimed to synthesize the existing evidence about the clinical benefit of antihistamines, used as monotherapy, compared with placebo or no treatment in children and adult patients with common cold. A total of 18 randomized clinical trials with 4342 participants were included. Main results were: 1) Antihistamines have a small (days one and two) beneficial effect in the short term on the severity of overall symptoms in adult patients, although this effect is not present in the medium to long term; 2) antihistamines were not associated with a clinically significant beneficial effect on the individual symptoms (nasal congestion, rhinorrhea, and sneezing); 3) Antihistamines are not associated with an increased risk of adverse effects; 4) No conclusion can be made about the effectiveness of antihistamines in pediatric populations. Our interpretation of the results is that the available evidence is insufficient to support the prescription or buying OTC antihistamines to relieve the symptoms of common cold without allergic component.

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  • Authors+Show Affiliations

    ,

    Department of Clinical and Experimental Medicine, Policlinico 'G. Martino'. University of Messina. Messina. Italy.

    ,

    Laboratório de Farmacologia Clínica e Terapêutica. Faculdade Medicina. Universidade de Lisboa. Portugal. Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

    ,

    Laboratório de Farmacologia Clínica e Terapêutica. Faculdade Medicina. Universidade de Lisboa. Portugal. Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

    Serviço de Farmacologia Clínica. Faculdade de Medicina de Lisboa. Lisboa. Portugal. Centro Colaborador Português da Rede Cochrane Iberoamericana. Lisboa. Portugal.

    Source

    Acta medica portuguesa 29:3 2016 Mar pg 164-7

    MeSH

    Common Cold
    Histamine Antagonists
    Humans
    Randomized Controlled Trials as Topic

    Pub Type(s)

    Journal Article
    Review

    Language

    por

    PubMed ID

    27285091

    Citation

    Sterrantino, Carmel, et al. "[Analysis of the Cochrane Review: Antihistamines for the Common Cold. Cochrane Database Syst Rev. 2015;11:CD009345]." Acta Medica Portuguesa, vol. 29, no. 3, 2016, pp. 164-7.
    Sterrantino C, Duarte G, Costa J, et al. [Analysis of the Cochrane Review: Antihistamines for the Common Cold. Cochrane Database Syst Rev. 2015;11:CD009345]. Acta Med Port. 2016;29(3):164-7.
    Sterrantino, C., Duarte, G., Costa, J., & Vaz-Carneiro, A. (2016). [Analysis of the Cochrane Review: Antihistamines for the Common Cold. Cochrane Database Syst Rev. 2015;11:CD009345]. Acta Medica Portuguesa, 29(3), pp. 164-7. doi:10.20344/amp.7526.
    Sterrantino C, et al. [Analysis of the Cochrane Review: Antihistamines for the Common Cold. Cochrane Database Syst Rev. 2015;11:CD009345]. Acta Med Port. 2016;29(3):164-7. PubMed PMID: 27285091.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Analysis of the Cochrane Review: Antihistamines for the Common Cold. Cochrane Database Syst Rev. 2015;11:CD009345]. AU - Sterrantino,Carmel, AU - Duarte,Gonçalo, AU - Costa,João, AU - Vaz-Carneiro,António, Y1 - 2016/03/31/ PY - 2016/02/15/received PY - 2016/02/16/accepted PY - 2016/6/11/entrez PY - 2016/6/11/pubmed PY - 2017/8/31/medline SP - 164 EP - 7 JF - Acta medica portuguesa JO - Acta Med Port VL - 29 IS - 3 N2 - The common cold is an acute, self-limiting inflammation of the mucosa of the upper airways, which may involve one or all the sinuses, nasopharynx, oropharynx and larynx. It is common to have at least one episode per year. Common cold symptoms, which may include sore throat, sneezing, nasal congestion, runny nose, headache, malaise and mild fever usually disappear within a few days without treatment. The causative agent of most colds is rhinovirus. Although not associated with mortality, common cold is associated with significant morbidity. There is no vaccine or cure for common cold and, therefore, their treatment is centered on relieving the symptoms. This Cochrane review aimed to synthesize the existing evidence about the clinical benefit of antihistamines, used as monotherapy, compared with placebo or no treatment in children and adult patients with common cold. A total of 18 randomized clinical trials with 4342 participants were included. Main results were: 1) Antihistamines have a small (days one and two) beneficial effect in the short term on the severity of overall symptoms in adult patients, although this effect is not present in the medium to long term; 2) antihistamines were not associated with a clinically significant beneficial effect on the individual symptoms (nasal congestion, rhinorrhea, and sneezing); 3) Antihistamines are not associated with an increased risk of adverse effects; 4) No conclusion can be made about the effectiveness of antihistamines in pediatric populations. Our interpretation of the results is that the available evidence is insufficient to support the prescription or buying OTC antihistamines to relieve the symptoms of common cold without allergic component. SN - 1646-0758 UR - https://www.unboundmedicine.com/medline/citation/27285091/[Analysis_of_the_Cochrane_Review:_Antihistamines_for_the_Common_Cold__Cochrane_Database_Syst_Rev__2015 L2 - http://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7526 DB - PRIME DP - Unbound Medicine ER -