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Antidiabetic Potential of Purple and Red Rice (Oryza sativa L.) Bran Extracts.
J Agric Food Chem. 2016 Jul 06; 64(26):5345-53.JA

Abstract

Pigmented rice contains anthocyanins and proanthocyanidins that are concentrated in the bran layer. In this study, we determined the phenolic, flavonoid, anthocyanin, and proanthocyanidin content of five rice bran (1 brown, 2 red, and 2 purple) extracts. Each bran extract was evaluated for inhibitory effects on α-amylase and α-glucosidase activity, two key glucosidases required for starch digestion in humans. All purple and red bran extracts inhibited α-glucosidase activity, however only the red rice bran extracts inhibited α-amylase activity. Additionally, each bran extract was examined for their ability to stimulate glucose uptake in 3T3-L1 adipocytes, a key function in glucose homeostasis. Basal glucose uptake was increased between 2.3- and 2.7-fold by exposure to the red bran extracts, and between 1.9- and 3.1-fold by exposure to the purple bran extracts. In red rice bran, the highest enzyme inhibition and glucose uptake was observed with a proanthocyanidin-enriched fraction. Both IITA red bran and IAC purple bran increased expression of GLUT1 and GLUT4 mRNA, and genes encoding insulin-signaling pathway proteins.

Authors+Show Affiliations

Southern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture , New Orleans, Louisiana 70124, United States.Southern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture , New Orleans, Louisiana 70124, United States.Dale Bumpers National Rice Research Center, Agricultural Research Service, U.S. Department of Agriculture , 2890 Highway 130 East, Stuttgart, Arkansas 72160, United States.Southern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture , New Orleans, Louisiana 70124, United States.Microbiome Therapeutics , 11001 120th Avenue, Broomfield, Colorado 80021, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27285791

Citation

Boue, Stephen M., et al. "Antidiabetic Potential of Purple and Red Rice (Oryza Sativa L.) Bran Extracts." Journal of Agricultural and Food Chemistry, vol. 64, no. 26, 2016, pp. 5345-53.
Boue SM, Daigle KW, Chen MH, et al. Antidiabetic Potential of Purple and Red Rice (Oryza sativa L.) Bran Extracts. J Agric Food Chem. 2016;64(26):5345-53.
Boue, S. M., Daigle, K. W., Chen, M. H., Cao, H., & Heiman, M. L. (2016). Antidiabetic Potential of Purple and Red Rice (Oryza sativa L.) Bran Extracts. Journal of Agricultural and Food Chemistry, 64(26), 5345-53. https://doi.org/10.1021/acs.jafc.6b01909
Boue SM, et al. Antidiabetic Potential of Purple and Red Rice (Oryza Sativa L.) Bran Extracts. J Agric Food Chem. 2016 Jul 6;64(26):5345-53. PubMed PMID: 27285791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic Potential of Purple and Red Rice (Oryza sativa L.) Bran Extracts. AU - Boue,Stephen M, AU - Daigle,Kim W, AU - Chen,Ming-Hsuan, AU - Cao,Heping, AU - Heiman,Mark L, Y1 - 2016/06/22/ PY - 2016/6/11/entrez PY - 2016/6/11/pubmed PY - 2017/4/14/medline KW - adipocytes KW - anthocyanins KW - brown rice bran KW - glucose uptake KW - phenolics KW - proanthocyanidins KW - purple rice bran KW - red rice bran KW - α-amylase KW - α-glucosidase SP - 5345 EP - 53 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 64 IS - 26 N2 - Pigmented rice contains anthocyanins and proanthocyanidins that are concentrated in the bran layer. In this study, we determined the phenolic, flavonoid, anthocyanin, and proanthocyanidin content of five rice bran (1 brown, 2 red, and 2 purple) extracts. Each bran extract was evaluated for inhibitory effects on α-amylase and α-glucosidase activity, two key glucosidases required for starch digestion in humans. All purple and red bran extracts inhibited α-glucosidase activity, however only the red rice bran extracts inhibited α-amylase activity. Additionally, each bran extract was examined for their ability to stimulate glucose uptake in 3T3-L1 adipocytes, a key function in glucose homeostasis. Basal glucose uptake was increased between 2.3- and 2.7-fold by exposure to the red bran extracts, and between 1.9- and 3.1-fold by exposure to the purple bran extracts. In red rice bran, the highest enzyme inhibition and glucose uptake was observed with a proanthocyanidin-enriched fraction. Both IITA red bran and IAC purple bran increased expression of GLUT1 and GLUT4 mRNA, and genes encoding insulin-signaling pathway proteins. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/27285791/Antidiabetic_Potential_of_Purple_and_Red_Rice__Oryza_sativa_L___Bran_Extracts_ L2 - https://doi.org/10.1021/acs.jafc.6b01909 DB - PRIME DP - Unbound Medicine ER -