Tags

Type your tag names separated by a space and hit enter

Coffee intake and the incident risk of cognitive disorders: A dose-response meta-analysis of nine prospective cohort studies.
Clin Nutr 2017; 36(3):730-736CN

Abstract

BACKGROUND & AIMS

Previous epidemiological studies have provided inconsistent conclusions on the impact of coffee consumption in the developing of cognitive disorders. However, no previous meta-analysis has pooled the evidence from the prospective cohort studies to assess the influence of coffee drinking and its potential dose-response patterns on the risk of developing cognitive disorders specifically.

METHODS

Two databases (PubMed and Embase) were searched for evidence of cohort studies from inception to February 2016. We used a generic inverse-variance method with a random-effects model to pool the fully adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs). In the dose-response analyses, a generalized least-squares trend estimation model was applied to computing the study-specific slopes.

RESULTS

Nine prospective cohort studies involving 34,282 participants were included in our study. The duration of follow-up years ranged from 1.3 to 28. Compared with <1 cup, daily drinking of 1-2 cups of coffee was inversely linked with the occurrence of cognitive disorders (i.e., Alzheimer's disease, dementia, cognitive decline, and cognitive impairment), and the pooled RR (95% CI) was 0.82 (0.71, 0.94) with evidence of non-significant heterogeneity (I2 = 25%). Non-significant differences were presented for the association between coffee consumption (>3 vs. <1 cup/d) and incident cognitive disorders. The dose-response analysis showed a "J-shaped" curve relationship of the risk of developing cognitive disorders with coffee consumption.

CONCLUSIONS

A "J-shaped" association was presented between coffee intake and incident cognitive disorders, with the lowest risk of incident cognitive disorders at a daily consumption level of 1-2 cups of coffee.

Authors+Show Affiliations

Department of Epidemiology, Institute of Geriatrics, Chinese PLA (People's Liberation Army) General Hospital, China; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, China.Department of Nanomedicine, Houston Methodist Research Institute, Houston, USA.Department of Epidemiology, Institute of Geriatrics, Chinese PLA (People's Liberation Army) General Hospital, China; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, China; State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, China. Electronic address: yhe301@x263.net.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

27288328

Citation

Wu, Lei, et al. "Coffee Intake and the Incident Risk of Cognitive Disorders: a Dose-response Meta-analysis of Nine Prospective Cohort Studies." Clinical Nutrition (Edinburgh, Scotland), vol. 36, no. 3, 2017, pp. 730-736.
Wu L, Sun D, He Y. Coffee intake and the incident risk of cognitive disorders: A dose-response meta-analysis of nine prospective cohort studies. Clin Nutr. 2017;36(3):730-736.
Wu, L., Sun, D., & He, Y. (2017). Coffee intake and the incident risk of cognitive disorders: A dose-response meta-analysis of nine prospective cohort studies. Clinical Nutrition (Edinburgh, Scotland), 36(3), pp. 730-736. doi:10.1016/j.clnu.2016.05.015.
Wu L, Sun D, He Y. Coffee Intake and the Incident Risk of Cognitive Disorders: a Dose-response Meta-analysis of Nine Prospective Cohort Studies. Clin Nutr. 2017;36(3):730-736. PubMed PMID: 27288328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee intake and the incident risk of cognitive disorders: A dose-response meta-analysis of nine prospective cohort studies. AU - Wu,Lei, AU - Sun,Dali, AU - He,Yao, Y1 - 2016/05/30/ PY - 2016/02/21/received PY - 2016/05/23/revised PY - 2016/05/23/accepted PY - 2016/6/12/pubmed PY - 2018/3/24/medline PY - 2016/6/12/entrez KW - Alzheimer's disease KW - Coffee intake KW - Cognitive disorders KW - Cognitive impairment KW - Dementia KW - Meta-analysis SP - 730 EP - 736 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 36 IS - 3 N2 - BACKGROUND & AIMS: Previous epidemiological studies have provided inconsistent conclusions on the impact of coffee consumption in the developing of cognitive disorders. However, no previous meta-analysis has pooled the evidence from the prospective cohort studies to assess the influence of coffee drinking and its potential dose-response patterns on the risk of developing cognitive disorders specifically. METHODS: Two databases (PubMed and Embase) were searched for evidence of cohort studies from inception to February 2016. We used a generic inverse-variance method with a random-effects model to pool the fully adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs). In the dose-response analyses, a generalized least-squares trend estimation model was applied to computing the study-specific slopes. RESULTS: Nine prospective cohort studies involving 34,282 participants were included in our study. The duration of follow-up years ranged from 1.3 to 28. Compared with <1 cup, daily drinking of 1-2 cups of coffee was inversely linked with the occurrence of cognitive disorders (i.e., Alzheimer's disease, dementia, cognitive decline, and cognitive impairment), and the pooled RR (95% CI) was 0.82 (0.71, 0.94) with evidence of non-significant heterogeneity (I2 = 25%). Non-significant differences were presented for the association between coffee consumption (>3 vs. <1 cup/d) and incident cognitive disorders. The dose-response analysis showed a "J-shaped" curve relationship of the risk of developing cognitive disorders with coffee consumption. CONCLUSIONS: A "J-shaped" association was presented between coffee intake and incident cognitive disorders, with the lowest risk of incident cognitive disorders at a daily consumption level of 1-2 cups of coffee. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/27288328/Coffee_intake_and_the_incident_risk_of_cognitive_disorders:_A_dose_response_meta_analysis_of_nine_prospective_cohort_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(16)30111-X DB - PRIME DP - Unbound Medicine ER -