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Coffee intake and the incident risk of cognitive disorders: A dose-response meta-analysis of nine prospective cohort studies.

Abstract

BACKGROUND & AIMS

Previous epidemiological studies have provided inconsistent conclusions on the impact of coffee consumption in the developing of cognitive disorders. However, no previous meta-analysis has pooled the evidence from the prospective cohort studies to assess the influence of coffee drinking and its potential dose-response patterns on the risk of developing cognitive disorders specifically.

METHODS

Two databases (PubMed and Embase) were searched for evidence of cohort studies from inception to February 2016. We used a generic inverse-variance method with a random-effects model to pool the fully adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs). In the dose-response analyses, a generalized least-squares trend estimation model was applied to computing the study-specific slopes.

RESULTS

Nine prospective cohort studies involving 34,282 participants were included in our study. The duration of follow-up years ranged from 1.3 to 28. Compared with <1 cup, daily drinking of 1-2 cups of coffee was inversely linked with the occurrence of cognitive disorders (i.e., Alzheimer's disease, dementia, cognitive decline, and cognitive impairment), and the pooled RR (95% CI) was 0.82 (0.71, 0.94) with evidence of non-significant heterogeneity (I2 = 25%). Non-significant differences were presented for the association between coffee consumption (>3 vs. <1 cup/d) and incident cognitive disorders. The dose-response analysis showed a "J-shaped" curve relationship of the risk of developing cognitive disorders with coffee consumption.

CONCLUSIONS

A "J-shaped" association was presented between coffee intake and incident cognitive disorders, with the lowest risk of incident cognitive disorders at a daily consumption level of 1-2 cups of coffee.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Institute of Geriatrics, Chinese PLA (People's Liberation Army) General Hospital, China; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, China.

    ,

    Department of Nanomedicine, Houston Methodist Research Institute, Houston, USA.

    Department of Epidemiology, Institute of Geriatrics, Chinese PLA (People's Liberation Army) General Hospital, China; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, China; State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, China. Electronic address: yhe301@x263.net.

    Source

    MeSH

    Coffee
    Cognition Disorders
    Dementia
    Diet
    Humans
    Incidence
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review

    Language

    eng

    PubMed ID

    27288328

    Citation

    Wu, Lei, et al. "Coffee Intake and the Incident Risk of Cognitive Disorders: a Dose-response Meta-analysis of Nine Prospective Cohort Studies." Clinical Nutrition (Edinburgh, Scotland), vol. 36, no. 3, 2017, pp. 730-736.
    Wu L, Sun D, He Y. Coffee intake and the incident risk of cognitive disorders: A dose-response meta-analysis of nine prospective cohort studies. Clin Nutr. 2017;36(3):730-736.
    Wu, L., Sun, D., & He, Y. (2017). Coffee intake and the incident risk of cognitive disorders: A dose-response meta-analysis of nine prospective cohort studies. Clinical Nutrition (Edinburgh, Scotland), 36(3), pp. 730-736. doi:10.1016/j.clnu.2016.05.015.
    Wu L, Sun D, He Y. Coffee Intake and the Incident Risk of Cognitive Disorders: a Dose-response Meta-analysis of Nine Prospective Cohort Studies. Clin Nutr. 2017;36(3):730-736. PubMed PMID: 27288328.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Coffee intake and the incident risk of cognitive disorders: A dose-response meta-analysis of nine prospective cohort studies. AU - Wu,Lei, AU - Sun,Dali, AU - He,Yao, Y1 - 2016/05/30/ PY - 2016/02/21/received PY - 2016/05/23/revised PY - 2016/05/23/accepted PY - 2016/6/12/pubmed PY - 2018/3/24/medline PY - 2016/6/12/entrez KW - Alzheimer's disease KW - Coffee intake KW - Cognitive disorders KW - Cognitive impairment KW - Dementia KW - Meta-analysis SP - 730 EP - 736 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 36 IS - 3 N2 - BACKGROUND & AIMS: Previous epidemiological studies have provided inconsistent conclusions on the impact of coffee consumption in the developing of cognitive disorders. However, no previous meta-analysis has pooled the evidence from the prospective cohort studies to assess the influence of coffee drinking and its potential dose-response patterns on the risk of developing cognitive disorders specifically. METHODS: Two databases (PubMed and Embase) were searched for evidence of cohort studies from inception to February 2016. We used a generic inverse-variance method with a random-effects model to pool the fully adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs). In the dose-response analyses, a generalized least-squares trend estimation model was applied to computing the study-specific slopes. RESULTS: Nine prospective cohort studies involving 34,282 participants were included in our study. The duration of follow-up years ranged from 1.3 to 28. Compared with <1 cup, daily drinking of 1-2 cups of coffee was inversely linked with the occurrence of cognitive disorders (i.e., Alzheimer's disease, dementia, cognitive decline, and cognitive impairment), and the pooled RR (95% CI) was 0.82 (0.71, 0.94) with evidence of non-significant heterogeneity (I2 = 25%). Non-significant differences were presented for the association between coffee consumption (>3 vs. <1 cup/d) and incident cognitive disorders. The dose-response analysis showed a "J-shaped" curve relationship of the risk of developing cognitive disorders with coffee consumption. CONCLUSIONS: A "J-shaped" association was presented between coffee intake and incident cognitive disorders, with the lowest risk of incident cognitive disorders at a daily consumption level of 1-2 cups of coffee. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/27288328/Coffee_intake_and_the_incident_risk_of_cognitive_disorders:_A_dose_response_meta_analysis_of_nine_prospective_cohort_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(16)30111-X DB - PRIME DP - Unbound Medicine ER -