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[A multifocal form of cutaneous leishmaniasis caused by Leishmania infantum in an immunocompetent child treated with a short course of liposomal amphotericin B].
Ann Dermatol Venereol. 2016 Oct; 143(10):622-624.AD

Abstract

BACKGROUND

Cutaneous leishmaniasis (CL) is a parasitic infestation caused by various species of Leishmania protozoa transmitted by the bite of phlebotomine sand flies. Herein we report a case of multifocal CL due to Leishmania infantum in an immunocompetent child treated with liposomal amphotericin B.

PATIENTS AND METHODS

A 10-month-old baby was referred for multiple ulcerated nodules of the face and upper limbs present for 5 months and following travel to North Morocco. Histological and parasitological examinations resulted in a diagnosis of CL due to L. infantum. The child was treated with intravenous liposomal amphotericin B in accordance with the schedule for visceral leishmaniasis (10mg/kg over 2 days), and rapid improvement of the lesions was seen within 10 days.

DISCUSSION

Clinical polymorphism of CL exists according to the infecting species. The multifocal presentation in our patient is very unusual for CL due to L. infantum in an immunocompetent child. To our knowledge, there have been no previous reports of successful use of parenteral liposomal amphotericin B for CL caused by L. infantum as described in our case.

Authors+Show Affiliations

Service de dermatologie, hôpital Archet 2, CHU, route de Saint-Antoine-de-Ginestière, 06200 Nice, France. Electronic address: helene.taquin@yahoo.fr.Service de dermatologie, hôpital Archet 2, CHU, route de Saint-Antoine-de-Ginestière, 06200 Nice, France.Service de parasitologie-mycologie, hôpital Archet 2, CHU, route de Saint-Antoine-de-Ginestière, 06200 Nice, France.Service de dermatologie, hôpital Archet 2, CHU, route de Saint-Antoine-de-Ginestière, 06200 Nice, France.

Pub Type(s)

Case Reports
Journal Article

Language

fre

PubMed ID

27292718

Citation

Taquin, H, et al. "[A Multifocal Form of Cutaneous Leishmaniasis Caused By Leishmania Infantum in an Immunocompetent Child Treated With a Short Course of Liposomal Amphotericin B]." Annales De Dermatologie Et De Venereologie, vol. 143, no. 10, 2016, pp. 622-624.
Taquin H, Chiaverini C, Marty P, et al. [A multifocal form of cutaneous leishmaniasis caused by Leishmania infantum in an immunocompetent child treated with a short course of liposomal amphotericin B]. Ann Dermatol Venereol. 2016;143(10):622-624.
Taquin, H., Chiaverini, C., Marty, P., & Lacour, J. P. (2016). [A multifocal form of cutaneous leishmaniasis caused by Leishmania infantum in an immunocompetent child treated with a short course of liposomal amphotericin B]. Annales De Dermatologie Et De Venereologie, 143(10), 622-624. https://doi.org/10.1016/j.annder.2016.03.025
Taquin H, et al. [A Multifocal Form of Cutaneous Leishmaniasis Caused By Leishmania Infantum in an Immunocompetent Child Treated With a Short Course of Liposomal Amphotericin B]. Ann Dermatol Venereol. 2016;143(10):622-624. PubMed PMID: 27292718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A multifocal form of cutaneous leishmaniasis caused by Leishmania infantum in an immunocompetent child treated with a short course of liposomal amphotericin B]. AU - Taquin,H, AU - Chiaverini,C, AU - Marty,P, AU - Lacour,J-P, Y1 - 2016/06/10/ PY - 2015/11/11/received PY - 2016/01/25/revised PY - 2016/03/17/accepted PY - 2016/6/14/pubmed PY - 2017/4/8/medline PY - 2016/6/14/entrez KW - Amphotéricine B liposomale (Ambisome(®)) KW - Infantile cutaneous leishmaniasis KW - Leishmania infantum KW - Leishmaniose cutanée infantile KW - Liposomal amphotericin B (Ambisome(®)) SP - 622 EP - 624 JF - Annales de dermatologie et de venereologie JO - Ann Dermatol Venereol VL - 143 IS - 10 N2 - BACKGROUND: Cutaneous leishmaniasis (CL) is a parasitic infestation caused by various species of Leishmania protozoa transmitted by the bite of phlebotomine sand flies. Herein we report a case of multifocal CL due to Leishmania infantum in an immunocompetent child treated with liposomal amphotericin B. PATIENTS AND METHODS: A 10-month-old baby was referred for multiple ulcerated nodules of the face and upper limbs present for 5 months and following travel to North Morocco. Histological and parasitological examinations resulted in a diagnosis of CL due to L. infantum. The child was treated with intravenous liposomal amphotericin B in accordance with the schedule for visceral leishmaniasis (10mg/kg over 2 days), and rapid improvement of the lesions was seen within 10 days. DISCUSSION: Clinical polymorphism of CL exists according to the infecting species. The multifocal presentation in our patient is very unusual for CL due to L. infantum in an immunocompetent child. To our knowledge, there have been no previous reports of successful use of parenteral liposomal amphotericin B for CL caused by L. infantum as described in our case. SN - 0151-9638 UR - https://www.unboundmedicine.com/medline/citation/27292718/[A_multifocal_form_of_cutaneous_leishmaniasis_caused_by_Leishmania_infantum_in_an_immunocompetent_child_treated_with_a_short_course_of_liposomal_amphotericin_B]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0151-9638(16)30096-5 DB - PRIME DP - Unbound Medicine ER -