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Proposal for new diagnostic criteria for low skeletal muscle mass based on computed tomography imaging in Asian adults.
Nutrition 2016 Nov-Dec; 32(11-12):1200-5N

Abstract

OBJECTIVES

Low skeletal muscle, referred to as sarcopenia, has been shown to be an independent predictor of lower overall survival in various kinds of diseases. Several studies have evaluated the low skeletal muscle mass using computed tomography (CT) imaging. However, the cutoff values based on CT imaging remain undetermined in Asian populations.

METHODS

Preoperative plain CT imaging at the third lumbar vertebrae level was used to measure the psoas muscle mass index (PMI, cm(2)/m(2)) in 541 adult donors for living donor liver transplantation (LDLT). We analyzed PMI distribution according to sex or donor age, and determined the sex-specific cutoff values of PMI to define low skeletal muscle mass.

RESULTS

PMI in men was significantly higher than observed in women (8.85 ± 1.61 cm(2)/m(2) versus 5.77 ± 1.21 cm(2)/m(2); P < 0.001). PMI was significantly lower in individuals ≥50 y than in younger donors in both men and women (P < 0.001 and P < 0.001, respectively). On the basis of the younger donor data, we determined the sex-specific cutoff values for the low skeletal muscle mass were 6.36 cm(2)/m(2) for men and 3.92 cm(2)/m(2) for women (mean - 2 SD).

CONCLUSION

Data from healthy young Asian adults were used to establish new criteria for low skeletal muscle mass that would be applicable for defining sarcopenia in Asian populations.

Authors+Show Affiliations

Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: kaido@kuhp.kyoto-u.ac.jp.Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Surgery, Mansoura University, Mansoura, Egypt.Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27292773

Citation

Hamaguchi, Yuhei, et al. "Proposal for New Diagnostic Criteria for Low Skeletal Muscle Mass Based On Computed Tomography Imaging in Asian Adults." Nutrition (Burbank, Los Angeles County, Calif.), vol. 32, no. 11-12, 2016, pp. 1200-5.
Hamaguchi Y, Kaido T, Okumura S, et al. Proposal for new diagnostic criteria for low skeletal muscle mass based on computed tomography imaging in Asian adults. Nutrition. 2016;32(11-12):1200-5.
Hamaguchi, Y., Kaido, T., Okumura, S., Kobayashi, A., Hammad, A., Tamai, Y., ... Uemoto, S. (2016). Proposal for new diagnostic criteria for low skeletal muscle mass based on computed tomography imaging in Asian adults. Nutrition (Burbank, Los Angeles County, Calif.), 32(11-12), pp. 1200-5. doi:10.1016/j.nut.2016.04.003.
Hamaguchi Y, et al. Proposal for New Diagnostic Criteria for Low Skeletal Muscle Mass Based On Computed Tomography Imaging in Asian Adults. Nutrition. 2016;32(11-12):1200-5. PubMed PMID: 27292773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proposal for new diagnostic criteria for low skeletal muscle mass based on computed tomography imaging in Asian adults. AU - Hamaguchi,Yuhei, AU - Kaido,Toshimi, AU - Okumura,Shinya, AU - Kobayashi,Atsushi, AU - Hammad,Ahmed, AU - Tamai,Yumiko, AU - Inagaki,Nobuya, AU - Uemoto,Shinji, Y1 - 2016/05/04/ PY - 2016/01/11/received PY - 2016/03/22/revised PY - 2016/04/11/accepted PY - 2016/6/14/entrez PY - 2016/6/14/pubmed PY - 2017/3/23/medline KW - Computed tomography KW - Cutoff value KW - Healthy young population KW - Living donor liver transplantation KW - Psoas muscle mass index KW - Sarcopenia SP - 1200 EP - 5 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 32 IS - 11-12 N2 - OBJECTIVES: Low skeletal muscle, referred to as sarcopenia, has been shown to be an independent predictor of lower overall survival in various kinds of diseases. Several studies have evaluated the low skeletal muscle mass using computed tomography (CT) imaging. However, the cutoff values based on CT imaging remain undetermined in Asian populations. METHODS: Preoperative plain CT imaging at the third lumbar vertebrae level was used to measure the psoas muscle mass index (PMI, cm(2)/m(2)) in 541 adult donors for living donor liver transplantation (LDLT). We analyzed PMI distribution according to sex or donor age, and determined the sex-specific cutoff values of PMI to define low skeletal muscle mass. RESULTS: PMI in men was significantly higher than observed in women (8.85 ± 1.61 cm(2)/m(2) versus 5.77 ± 1.21 cm(2)/m(2); P < 0.001). PMI was significantly lower in individuals ≥50 y than in younger donors in both men and women (P < 0.001 and P < 0.001, respectively). On the basis of the younger donor data, we determined the sex-specific cutoff values for the low skeletal muscle mass were 6.36 cm(2)/m(2) for men and 3.92 cm(2)/m(2) for women (mean - 2 SD). CONCLUSION: Data from healthy young Asian adults were used to establish new criteria for low skeletal muscle mass that would be applicable for defining sarcopenia in Asian populations. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/27292773/Proposal_for_new_diagnostic_criteria_for_low_skeletal_muscle_mass_based_on_computed_tomography_imaging_in_Asian_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(16)30043-0 DB - PRIME DP - Unbound Medicine ER -