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Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort.
Cancer Causes Control 2016; 27(7):919-27CC

Abstract

BACKGROUND

The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC.

METHODS

We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective cohort of approximately half a million men and women from ten European countries. Overall obesity and abdominal obesity were assessed by body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Multivariate Cox proportional hazards regression modeling was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs). Stratified analyses were conducted by sex, BMI, and smoking status.

RESULTS

During an average of 13.9 years of follow-up, 131 incident cases of SIC (including 41 adenocarcinomas, 44 malignant carcinoid tumors, 15 sarcomas and 10 lymphomas, and 21 unknown histology) were identified. WC was positively associated with SIC in a crude model that also included BMI (HR per 5-cm increase = 1.20, 95 % CI 1.04, 1.39), but this association attenuated in the multivariable model (HR 1.18, 95 % CI 0.98, 1.42). However, the association between WC and SIC was strengthened when the analysis was restricted to adenocarcinoma of the small intestine (multivariable HR adjusted for BMI = 1.56, 95 % CI 1.11, 2.17). There were no other significant associations.

CONCLUSION

WC, rather than BMI, may be positively associated with adenocarcinomas but not carcinoid tumors of the small intestine.

IMPACT

Abdominal obesity is a potential risk factor for adenocarcinoma in the small intestine.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK. yunxia.lu@imperial.ac.uk.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK.International Agency for Research on Cancer (IARC-WHO), Lyon, France.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.International Agency for Research on Cancer (IARC-WHO), Lyon, France.Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.Department of Surgery, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden.Department of Odontology, Umeå University, Umeå, Sweden. Department of Biobank Research, Umeå University, Umeå, Sweden.Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden. Department of Biobank Research, Umeå University, Umeå, Sweden.Dipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy.Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133, Milan, Italy.Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute ISPO, Florence, Italy.Cancer Registry and Histopathology Unit, "Civic - M.P. Arezzo" Hospital, ASP Ragusa, Italy.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.Hellenic Health Foundation, 23 Alexandroupoleos, 115 27, Athens, Greece. Bureau of Epidemiologic Research, Academy of Athens, 13 Kaisareias Street, 115 27, Athens, Greece. Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, 115 27, Athens, Greece.Hellenic Health Foundation, 23 Alexandroupoleos, 115 27, Athens, Greece.Hellenic Health Foundation, 23 Alexandroupoleos, 115 27, Athens, Greece.Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Av. Gran Via 199-203, 08908, L'Hospitalet de Llobregat, Spain.Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain. Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain. Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain. Navarre Public Health Institute, Pamplona, Spain.Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, 94805, Villejuif, France. Université Paris Sud, UMRS 1018, 94805, Villejuif, France. Institut Gustave Roussy, 94805, Villejuif, France.Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, 94805, Villejuif, France. Université Paris Sud, UMRS 1018, 94805, Villejuif, France. Institut Gustave Roussy, 94805, Villejuif, France.Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, 94805, Villejuif, France. Université Paris Sud, UMRS 1018, 94805, Villejuif, France. Institut Gustave Roussy, 94805, Villejuif, France.Department of Community Medicine, Faculty of Health Sciences, The Arctic University of Norway, University of Tromsø, Tromsø, Norway. Department of Research, Cancer Registry of Norway, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Department of Genetic Epidemiology, Folkhälsan Research Center, Helsinki, Finland.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27294726

Citation

Lu, Yunxia, et al. "Comparison of Abdominal Adiposity and Overall Obesity in Relation to Risk of Small Intestinal Cancer in a European Prospective Cohort." Cancer Causes & Control : CCC, vol. 27, no. 7, 2016, pp. 919-27.
Lu Y, Cross AJ, Murphy N, et al. Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort. Cancer Causes Control. 2016;27(7):919-27.
Lu, Y., Cross, A. J., Murphy, N., Freisling, H., Travis, R. C., Ferrari, P., ... Riboli, E. (2016). Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort. Cancer Causes & Control : CCC, 27(7), pp. 919-27. doi:10.1007/s10552-016-0772-z.
Lu Y, et al. Comparison of Abdominal Adiposity and Overall Obesity in Relation to Risk of Small Intestinal Cancer in a European Prospective Cohort. Cancer Causes Control. 2016;27(7):919-27. PubMed PMID: 27294726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort. AU - Lu,Yunxia, AU - Cross,Amanda J, AU - Murphy,Neil, AU - Freisling,Heinz, AU - Travis,Ruth C, AU - Ferrari,Pietro, AU - Katzke,Verena A, AU - Kaaks,Rudolf, AU - Olsson,Åsa, AU - Johansson,Ingegerd, AU - Renström,Frida, AU - Panico,Salvatore, AU - Pala,Valeria, AU - Palli,Domenico, AU - Tumino,Rosario, AU - Peeters,Petra H, AU - Siersema,Peter D, AU - Bueno-de-Mesquita,H B, AU - Trichopoulou,Antonia, AU - Klinaki,Eleni, AU - Tsironis,Christos, AU - Agudo,Antonio, AU - Navarro,Carmen, AU - Sánchez,María-José, AU - Barricarte,Aurelio, AU - Boutron-Ruault,Marie-Christine, AU - Fagherazzi,Guy, AU - Racine,Antoine, AU - Weiderpass,Elisabete, AU - Gunter,Marc J, AU - Riboli,Elio, Y1 - 2016/06/13/ PY - 2015/11/24/received PY - 2016/05/17/accepted PY - 2016/6/14/entrez PY - 2016/6/14/pubmed PY - 2017/2/6/medline KW - Abdominal obesity KW - Cancer KW - Obesity KW - Small intestine SP - 919 EP - 27 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 27 IS - 7 N2 - BACKGROUND: The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC. METHODS: We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective cohort of approximately half a million men and women from ten European countries. Overall obesity and abdominal obesity were assessed by body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Multivariate Cox proportional hazards regression modeling was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs). Stratified analyses were conducted by sex, BMI, and smoking status. RESULTS: During an average of 13.9 years of follow-up, 131 incident cases of SIC (including 41 adenocarcinomas, 44 malignant carcinoid tumors, 15 sarcomas and 10 lymphomas, and 21 unknown histology) were identified. WC was positively associated with SIC in a crude model that also included BMI (HR per 5-cm increase = 1.20, 95 % CI 1.04, 1.39), but this association attenuated in the multivariable model (HR 1.18, 95 % CI 0.98, 1.42). However, the association between WC and SIC was strengthened when the analysis was restricted to adenocarcinoma of the small intestine (multivariable HR adjusted for BMI = 1.56, 95 % CI 1.11, 2.17). There were no other significant associations. CONCLUSION: WC, rather than BMI, may be positively associated with adenocarcinomas but not carcinoid tumors of the small intestine. IMPACT: Abdominal obesity is a potential risk factor for adenocarcinoma in the small intestine. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/27294726/Comparison_of_abdominal_adiposity_and_overall_obesity_in_relation_to_risk_of_small_intestinal_cancer_in_a_European_Prospective_Cohort_ L2 - https://doi.org/10.1007/s10552-016-0772-z DB - PRIME DP - Unbound Medicine ER -