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The use of collagen-based matrices in the treatment of full-thickness wounds.
Burns 2016; 42(6):1257-64B

Abstract

Chronic and complex full-thickness wounds have become increasingly prevalent. Besides autologous skin transplantation, innovative wound dressing products have gained interest, as the functional and esthetic outcome is still limited. In this respect, the effect of a novel modifiable collagen-gelatin fleece on the healing of deep dermal wounds was examined and compared with untreated controls and Matriderm(®). A total of 48 full-thickness skin defects were generated on six minipigs and treated with the novel collagen-gelatin fleece of different thicknesses in single or multiple application (n=36) or treated with Matriderm(®) in a single application (n=6), or the wounds were left untreated (n=6). Wound healing was analyzed planimetrically by wound closure per time and histologically with regard to epidermal thickness and cell density. Compared to untreated wounds, wound closure per time and histological skin quality with regard to the mean epidermal thickness and epidermal cell amount were enhanced in both treatment groups. Overall, the best results for the novel collagen-gelatin fleece were achieved for multiple applications with a thickness of 150g/m(2). The novel biomaterial shows accelerated and improved dermal wound repair in a minipig model. As the manufacturing process of the scaffold allows the integration of bioactive substances such as antibiotics and growth factors, we intend to design a composite biomaterial using this scaffold as a carrier matrix.

Authors+Show Affiliations

Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tübingen, Tübingen, Germany.Department of Plastic, Hand, Reconstructive and Aesthetic Surgery, Helios Clinic Wuppertal GmbH, University Witten/Herdecke, Herdecke, Germany.Department of Medical Oncology and Hematology, Medical Center II, University Hospital of Tuebingen, Eberhard Karls University Tübingen, Tübingen, Germany. Electronic address: jan-ole-werner@gmx.de.Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tübingen, Tübingen, Germany.Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tübingen, Tübingen, Germany.Department of Plastic, Hand, Reconstructive and Aesthetic Surgery, Helios Clinic Wuppertal GmbH, University Witten/Herdecke, Herdecke, Germany.Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tübingen, Tübingen, Germany.Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tübingen, Tübingen, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27297940

Citation

Petersen, Wiebke, et al. "The Use of Collagen-based Matrices in the Treatment of Full-thickness Wounds." Burns : Journal of the International Society for Burn Injuries, vol. 42, no. 6, 2016, pp. 1257-64.
Petersen W, Rahmanian-Schwarz A, Werner JO, et al. The use of collagen-based matrices in the treatment of full-thickness wounds. Burns. 2016;42(6):1257-64.
Petersen, W., Rahmanian-Schwarz, A., Werner, J. O., Schiefer, J., Rothenberger, J., Hübner, G., ... Held, M. (2016). The use of collagen-based matrices in the treatment of full-thickness wounds. Burns : Journal of the International Society for Burn Injuries, 42(6), pp. 1257-64. doi:10.1016/j.burns.2016.03.017.
Petersen W, et al. The Use of Collagen-based Matrices in the Treatment of Full-thickness Wounds. Burns. 2016;42(6):1257-64. PubMed PMID: 27297940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of collagen-based matrices in the treatment of full-thickness wounds. AU - Petersen,Wiebke, AU - Rahmanian-Schwarz,Afshin, AU - Werner,Jan-Ole, AU - Schiefer,Jennifer, AU - Rothenberger,Jens, AU - Hübner,Gunnar, AU - Schaller,Hans-Eberhard, AU - Held,Manuel, Y1 - 2016/06/11/ PY - 2015/06/14/received PY - 2016/03/15/revised PY - 2016/03/23/accepted PY - 2016/6/15/entrez PY - 2016/6/15/pubmed PY - 2017/3/14/medline SP - 1257 EP - 64 JF - Burns : journal of the International Society for Burn Injuries JO - Burns VL - 42 IS - 6 N2 - Chronic and complex full-thickness wounds have become increasingly prevalent. Besides autologous skin transplantation, innovative wound dressing products have gained interest, as the functional and esthetic outcome is still limited. In this respect, the effect of a novel modifiable collagen-gelatin fleece on the healing of deep dermal wounds was examined and compared with untreated controls and Matriderm(®). A total of 48 full-thickness skin defects were generated on six minipigs and treated with the novel collagen-gelatin fleece of different thicknesses in single or multiple application (n=36) or treated with Matriderm(®) in a single application (n=6), or the wounds were left untreated (n=6). Wound healing was analyzed planimetrically by wound closure per time and histologically with regard to epidermal thickness and cell density. Compared to untreated wounds, wound closure per time and histological skin quality with regard to the mean epidermal thickness and epidermal cell amount were enhanced in both treatment groups. Overall, the best results for the novel collagen-gelatin fleece were achieved for multiple applications with a thickness of 150g/m(2). The novel biomaterial shows accelerated and improved dermal wound repair in a minipig model. As the manufacturing process of the scaffold allows the integration of bioactive substances such as antibiotics and growth factors, we intend to design a composite biomaterial using this scaffold as a carrier matrix. SN - 1879-1409 UR - https://www.unboundmedicine.com/medline/citation/27297940/The_use_of_collagen_based_matrices_in_the_treatment_of_full_thickness_wounds_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0305-4179(16)30035-3 DB - PRIME DP - Unbound Medicine ER -