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Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis.
Indian J Pharmacol 2016 May-Jun; 48(3):312-5IJ

Abstract

OBJECTIVE

Equisetum arvense has been used to treat bone diseases. The traditional supplementation of calcium and Vitamin D for osteoporosis patients is insufficient considering the rise in patients every year. We have observed that extending the calcium and Vitamin D supplement with L-lysine, L-proline, L-arginine, and L-ascorbic acid (N) positively affects bone mineralization in ovariectomized rat. Here, we report a further extension of the above supplement with E. arvense.

MATERIALS AND METHODS

The changes in serum biomarkers, bone mineral content, and femur bone histology were studied and compared to the standard drug for osteoporosis, namely raloxifene (RAL).

RESULTS

We report a significant change in formation and resorption markers of bone as well as in cortical bone thickness and trabecular width in N and N + EA groups. The treatment N + EA also restored lipid profile near to normal level compared to ovariectomized group.

CONCLUSIONS

Treatment N + EA was found to be as effective as RAL in reversing the osteoporotic changes.

Authors+Show Affiliations

University Department of Biochemistry, RTM Nagpur University, Nagpur, Maharashtra, India.University Department of Biochemistry, RTM Nagpur University, Nagpur, Maharashtra, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27298503

Citation

Kotwal, Swati D., and Smita R. Badole. "Anabolic Therapy With Equisetum Arvense Along With Bone Mineralising Nutrients in Ovariectomized Rat Model of Osteoporosis." Indian Journal of Pharmacology, vol. 48, no. 3, 2016, pp. 312-5.
Kotwal SD, Badole SR. Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis. Indian J Pharmacol. 2016;48(3):312-5.
Kotwal, S. D., & Badole, S. R. (2016). Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis. Indian Journal of Pharmacology, 48(3), pp. 312-5. doi:10.4103/0253-7613.182880.
Kotwal SD, Badole SR. Anabolic Therapy With Equisetum Arvense Along With Bone Mineralising Nutrients in Ovariectomized Rat Model of Osteoporosis. Indian J Pharmacol. 2016;48(3):312-5. PubMed PMID: 27298503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis. AU - Kotwal,Swati D, AU - Badole,Smita R, PY - 2016/6/15/entrez PY - 2016/6/15/pubmed PY - 2017/5/24/medline KW - Bone mineralizing nutrients KW - Equisetum arvense KW - osteoporosis prevention SP - 312 EP - 5 JF - Indian journal of pharmacology JO - Indian J Pharmacol VL - 48 IS - 3 N2 - OBJECTIVE: Equisetum arvense has been used to treat bone diseases. The traditional supplementation of calcium and Vitamin D for osteoporosis patients is insufficient considering the rise in patients every year. We have observed that extending the calcium and Vitamin D supplement with L-lysine, L-proline, L-arginine, and L-ascorbic acid (N) positively affects bone mineralization in ovariectomized rat. Here, we report a further extension of the above supplement with E. arvense. MATERIALS AND METHODS: The changes in serum biomarkers, bone mineral content, and femur bone histology were studied and compared to the standard drug for osteoporosis, namely raloxifene (RAL). RESULTS: We report a significant change in formation and resorption markers of bone as well as in cortical bone thickness and trabecular width in N and N + EA groups. The treatment N + EA also restored lipid profile near to normal level compared to ovariectomized group. CONCLUSIONS: Treatment N + EA was found to be as effective as RAL in reversing the osteoporotic changes. SN - 1998-3751 UR - https://www.unboundmedicine.com/medline/citation/27298503/Anabolic_therapy_with_Equisetum_arvense_along_with_bone_mineralising_nutrients_in_ovariectomized_rat_model_of_osteoporosis_ L2 - http://www.ijp-online.com/article.asp?issn=0253-7613;year=2016;volume=48;issue=3;spage=312;epage=315;aulast=Kotwal DB - PRIME DP - Unbound Medicine ER -