Tags

Type your tag names separated by a space and hit enter

Retrospective cohort analysis of healthcare claims in the United States characterising asthma exacerbations in paediatric patients.
World Allergy Organ J. 2016; 9:18.WA

Abstract

BACKGROUND

Asthma is the most common chronic disease in childhood and places a significant burden on public and private health systems. This retrospective cohort analysis utilised administrative healthcare claims data (US Clinformatics™ Multiplan database; compliant with the US Department of Health & Human Services Health Insurance Portability and Accountability Act) to characterise asthma exacerbations requiring intervention in a US paediatric patient population.

METHODS

Patients aged > 1-17 years with a recorded asthma diagnosis and receiving treatment were identified in the US Clinformatics™ Multiplan database over a 9-year period (2004-2012). Both incident and prevalent cases of asthma were included, with the most recently recorded asthma diagnosis designated as the index date. The 12-month period following the index date was analysed for asthma exacerbations, defined as an event requiring treatment with systemic corticosteroid or resulting in an asthma-related hospitalisation or emergency department visit.

RESULTS

Data from 734,114 children with asthma (41.5 % females, 58.5 % males) were analysed, of this cohort 34.4 % experienced ≥ 1 exacerbation during the follow-up period. The proportion who experienced ≥ 1 exacerbation increased from 28.9 % in 2004 to 36.3 % in 2012, based on the reported index date. Their mean annual exacerbation frequency was 1.4; 85.8 % of exacerbations were defined by systemic corticosteroids use. A consistent trend of increased exacerbation incidence in the fall and early winter was observed, in particular exacerbations defined by systemic corticosteroid use. A greater proportion of asthma-related hospitalisations were associated with younger age.

CONCLUSIONS

Approximately one-third of children experienced ≥ 1 exacerbation in real-world clinical practice. A targeted treatment approach with a focus on those with a history of recurrent exacerbations is recommended to improve asthma control. This targeted approach could also minimise the frequent systemic corticosteroid exposure particularly at an early age when side effects of systemic corticosteroids are more pronounced.

Authors+Show Affiliations

UCB Biosciences Inc., 8010 Arco Corporate Drive, Raleigh, NC 27617 USA.GSK, Worldwide Epidemiology, Stockley Park West, Uxbridge, Middlesex UK.Genentech, 1 DNA Way, South San Francisco, CA 94401 USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27298711

Citation

Suruki, Robert Y., et al. "Retrospective Cohort Analysis of Healthcare Claims in the United States Characterising Asthma Exacerbations in Paediatric Patients." The World Allergy Organization Journal, vol. 9, 2016, p. 18.
Suruki RY, Boudiaf N, Ortega HG. Retrospective cohort analysis of healthcare claims in the United States characterising asthma exacerbations in paediatric patients. World Allergy Organ J. 2016;9:18.
Suruki, R. Y., Boudiaf, N., & Ortega, H. G. (2016). Retrospective cohort analysis of healthcare claims in the United States characterising asthma exacerbations in paediatric patients. The World Allergy Organization Journal, 9, 18. https://doi.org/10.1186/s40413-016-0109-0
Suruki RY, Boudiaf N, Ortega HG. Retrospective Cohort Analysis of Healthcare Claims in the United States Characterising Asthma Exacerbations in Paediatric Patients. World Allergy Organ J. 2016;9:18. PubMed PMID: 27298711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retrospective cohort analysis of healthcare claims in the United States characterising asthma exacerbations in paediatric patients. AU - Suruki,Robert Y, AU - Boudiaf,Nada, AU - Ortega,Hector G, Y1 - 2016/06/06/ PY - 2016/01/25/received PY - 2016/05/18/accepted PY - 2016/6/15/entrez PY - 2016/6/15/pubmed PY - 2016/6/15/medline KW - Asthma KW - Exacerbations KW - Paediatric KW - Systemic corticosteroids SP - 18 EP - 18 JF - The World Allergy Organization journal JO - World Allergy Organ J VL - 9 N2 - BACKGROUND: Asthma is the most common chronic disease in childhood and places a significant burden on public and private health systems. This retrospective cohort analysis utilised administrative healthcare claims data (US Clinformatics™ Multiplan database; compliant with the US Department of Health & Human Services Health Insurance Portability and Accountability Act) to characterise asthma exacerbations requiring intervention in a US paediatric patient population. METHODS: Patients aged > 1-17 years with a recorded asthma diagnosis and receiving treatment were identified in the US Clinformatics™ Multiplan database over a 9-year period (2004-2012). Both incident and prevalent cases of asthma were included, with the most recently recorded asthma diagnosis designated as the index date. The 12-month period following the index date was analysed for asthma exacerbations, defined as an event requiring treatment with systemic corticosteroid or resulting in an asthma-related hospitalisation or emergency department visit. RESULTS: Data from 734,114 children with asthma (41.5 % females, 58.5 % males) were analysed, of this cohort 34.4 % experienced ≥ 1 exacerbation during the follow-up period. The proportion who experienced ≥ 1 exacerbation increased from 28.9 % in 2004 to 36.3 % in 2012, based on the reported index date. Their mean annual exacerbation frequency was 1.4; 85.8 % of exacerbations were defined by systemic corticosteroids use. A consistent trend of increased exacerbation incidence in the fall and early winter was observed, in particular exacerbations defined by systemic corticosteroid use. A greater proportion of asthma-related hospitalisations were associated with younger age. CONCLUSIONS: Approximately one-third of children experienced ≥ 1 exacerbation in real-world clinical practice. A targeted treatment approach with a focus on those with a history of recurrent exacerbations is recommended to improve asthma control. This targeted approach could also minimise the frequent systemic corticosteroid exposure particularly at an early age when side effects of systemic corticosteroids are more pronounced. SN - 1939-4551 UR - https://www.unboundmedicine.com/medline/citation/27298711/Retrospective_cohort_analysis_of_healthcare_claims_in_the_United_States_characterising_asthma_exacerbations_in_paediatric_patients_ L2 - https://waojournal.biomedcentral.com/articles/10.1186/s40413-016-0109-0 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.