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The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury.
Drug Dev Res. 2016 08; 77(5):217-26.DD

Abstract

Preclinical Research The current work evaluates the interaction between two commonly used drugs, tramadol (Tra) and gabapentin (Gbp). Dose-response curves (DRC) and isobolographic analysis were used to confirm their synergistic antihyperalgesic and anti-allodynic responses in a rat neuropathic pain model involving chronic constriction injury of the sciatic nerve and in von Frey and acetone tests. Tra and Gbp produced dose-dependent antihyperalgesic and anti-allodynic effects. Dose-response studies of combinations of Tra and Gbp in combination showed the DRC was leftward-shifted compared to the DRCs for each compound alone. One combination demonstrated both antihyperalgesic and anti-allodynic effects greater than those observed after individual administration. The remaining combinations demonstrated an additive effect. The Tra+Gbp combination demonstrated a potentiative effect with smaller doses of Tra. Additionally, it was determined lethal dose 50 (LD50) of Tra alone and tramadol + Gbp 10 using mice to 48 h post administration. The DRC (death) were similar for Tra alone and in Tra in combination, despite the improved effectiveness of Tra in the presence of GBP, 10 mg/kg. A combination of these drugs could be effective in neuropathic pain therapy because they can produce potentiative (at a low dose) or additive effects. Drug Dev Res 77 : 217-226, 2016. © 2016 Wiley Periodicals, Inc.

Authors+Show Affiliations

Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P., 14330, Delegación Tlálpan, México D.F., México.Área Académica de Farmacia del Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.Sección de Estudios de Posgrado e Investigación de la Escuela Superior de Medicina del IPN, C.P. 11340, México D.F., México.Depto. de Sistemas Biológicos UAM-Xochimilco, C.P. 04960, México, D.F., México.Depto. de Sistemas Biológicos UAM-Xochimilco, C.P. 04960, México, D.F., México.Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P., 14330, Delegación Tlálpan, México D.F., México.Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P., 14330, Delegación Tlálpan, México D.F., México.Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P., 14330, Delegación Tlálpan, México D.F., México.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27300150

Citation

Corona-Ramos, Janette Nallely, et al. "The Antinociceptive Effects of Tramadol And/or Gabapentin On Rat Neuropathic Pain Induced By a Chronic Constriction Injury." Drug Development Research, vol. 77, no. 5, 2016, pp. 217-26.
Corona-Ramos JN, De la O-Arciniega M, Déciga-Campos M, et al. The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury. Drug Dev Res. 2016;77(5):217-26.
Corona-Ramos, J. N., De la O-Arciniega, M., Déciga-Campos, M., Medina-López, J. R., Domínguez-Ramírez, A. M., Jaramillo-Morales, O. A., Espinosa-Juárez, J. V., & López-Muñoz, F. J. (2016). The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury. Drug Development Research, 77(5), 217-26. https://doi.org/10.1002/ddr.21313
Corona-Ramos JN, et al. The Antinociceptive Effects of Tramadol And/or Gabapentin On Rat Neuropathic Pain Induced By a Chronic Constriction Injury. Drug Dev Res. 2016;77(5):217-26. PubMed PMID: 27300150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury. AU - Corona-Ramos,Janette Nallely, AU - De la O-Arciniega,Minarda, AU - Déciga-Campos,Myrna, AU - Medina-López,José Raúl, AU - Domínguez-Ramírez,Adriana Miriam, AU - Jaramillo-Morales,Osmar Antonio, AU - Espinosa-Juárez,Josué Vidal, AU - López-Muñoz,Francisco Javier, Y1 - 2016/06/14/ PY - 2016/04/01/received PY - 2016/05/07/accepted PY - 2016/6/15/entrez PY - 2016/6/15/pubmed PY - 2017/11/9/medline KW - combination KW - gabapentin KW - interaction KW - neuropathic pain KW - tramadol SP - 217 EP - 26 JF - Drug development research JO - Drug Dev Res VL - 77 IS - 5 N2 - Preclinical Research The current work evaluates the interaction between two commonly used drugs, tramadol (Tra) and gabapentin (Gbp). Dose-response curves (DRC) and isobolographic analysis were used to confirm their synergistic antihyperalgesic and anti-allodynic responses in a rat neuropathic pain model involving chronic constriction injury of the sciatic nerve and in von Frey and acetone tests. Tra and Gbp produced dose-dependent antihyperalgesic and anti-allodynic effects. Dose-response studies of combinations of Tra and Gbp in combination showed the DRC was leftward-shifted compared to the DRCs for each compound alone. One combination demonstrated both antihyperalgesic and anti-allodynic effects greater than those observed after individual administration. The remaining combinations demonstrated an additive effect. The Tra+Gbp combination demonstrated a potentiative effect with smaller doses of Tra. Additionally, it was determined lethal dose 50 (LD50) of Tra alone and tramadol + Gbp 10 using mice to 48 h post administration. The DRC (death) were similar for Tra alone and in Tra in combination, despite the improved effectiveness of Tra in the presence of GBP, 10 mg/kg. A combination of these drugs could be effective in neuropathic pain therapy because they can produce potentiative (at a low dose) or additive effects. Drug Dev Res 77 : 217-226, 2016. © 2016 Wiley Periodicals, Inc. SN - 1098-2299 UR - https://www.unboundmedicine.com/medline/citation/27300150/The_Antinociceptive_Effects_of_Tramadol_and/or_Gabapentin_on_Rat_Neuropathic_Pain_Induced_by_a_Chronic_Constriction_Injury_ L2 - https://doi.org/10.1002/ddr.21313 DB - PRIME DP - Unbound Medicine ER -