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Oxygenated monoterpenes-rich volatile oils as potential antifungal agents for dermatophytes.
Nat Prod Res. 2017 Feb; 31(4):460-464.NP

Abstract

Essential oils (EOs) extracted from Lavandula luisieri and Cymbopogon citratus were tested for their antifungal activity against ten clinical isolates of dermatophytes isolated from cases of tinea pedis. Inhibition of conidial germination and antifungal drug/EO combination assay were tested on two ATCC reference strains of Trichophyton rubrum and Trichophyton mentagrophytes. EOs were characterised by high amount of oxygenated monoterpenes in their composition. Strong antifungal activity was observed for the majority of clinical strains, and fungicidal activity was demonstrated. Positive interaction between L. luisieri EO combined with terbinafine was observed against terbinafine-resistant strain (Tr ATCC MYA-4438). Significative reduction of the germination was observed above 100 μg mL-1. Both oils were safe to macrophage mammalian cells at tested concentration. This study describes the antifungal activity of L. luisieri and C. citratus EOs against dermatophytes, which could be useful in designing new formulations for topical treatments.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Dias N
a CEB - Centre of Biological Engineering , University of Minho, Campus Gualtar , Braga , Portugal.
Dias MC
b CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde , Gandra , Portugal.
Cavaleiro C
c CEF - Centro de Estudos Farmacêuticos/Faculty of Pharmacy , University of Coimbra , Coimbra , Portugal.
Sousa MC
c CEF - Centro de Estudos Farmacêuticos/Faculty of Pharmacy , University of Coimbra , Coimbra , Portugal. d CNC - Center for Neuroscience and Cell Biology , University of Coimbra , Coimbra , Portugal.
Lima N
a CEB - Centre of Biological Engineering , University of Minho, Campus Gualtar , Braga , Portugal.
Machado M
b CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde , Gandra , Portugal. c CEF - Centro de Estudos Farmacêuticos/Faculty of Pharmacy , University of Coimbra , Coimbra , Portugal. e CIBIO - Research Centre in Biodiversity and Genetic Resources, InBIO , Universidade do Porto , Campus Agrário de Vairão, Vila do Conde , Portugal.

MeSH

Antifungal AgentsArthrodermataceaeMicrobial Sensitivity TestsMonoterpenesOils, VolatileOxygenTrichophyton

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27309978

Citation

Dias, N, et al. "Oxygenated Monoterpenes-rich Volatile Oils as Potential Antifungal Agents for Dermatophytes." Natural Product Research, vol. 31, no. 4, 2017, pp. 460-464.
Dias N, Dias MC, Cavaleiro C, et al. Oxygenated monoterpenes-rich volatile oils as potential antifungal agents for dermatophytes. Nat Prod Res. 2017;31(4):460-464.
Dias, N., Dias, M. C., Cavaleiro, C., Sousa, M. C., Lima, N., & Machado, M. (2017). Oxygenated monoterpenes-rich volatile oils as potential antifungal agents for dermatophytes. Natural Product Research, 31(4), 460-464. https://doi.org/10.1080/14786419.2016.1195379
Dias N, et al. Oxygenated Monoterpenes-rich Volatile Oils as Potential Antifungal Agents for Dermatophytes. Nat Prod Res. 2017;31(4):460-464. PubMed PMID: 27309978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxygenated monoterpenes-rich volatile oils as potential antifungal agents for dermatophytes. AU - Dias,N, AU - Dias,M C, AU - Cavaleiro,C, AU - Sousa,M C, AU - Lima,N, AU - Machado,M, Y1 - 2016/06/16/ PY - 2016/6/17/pubmed PY - 2017/5/11/medline PY - 2016/6/17/entrez KW - Antifungals KW - dermatophytes KW - pathogenic fungi KW - skin infections SP - 460 EP - 464 JF - Natural product research JO - Nat Prod Res VL - 31 IS - 4 N2 - Essential oils (EOs) extracted from Lavandula luisieri and Cymbopogon citratus were tested for their antifungal activity against ten clinical isolates of dermatophytes isolated from cases of tinea pedis. Inhibition of conidial germination and antifungal drug/EO combination assay were tested on two ATCC reference strains of Trichophyton rubrum and Trichophyton mentagrophytes. EOs were characterised by high amount of oxygenated monoterpenes in their composition. Strong antifungal activity was observed for the majority of clinical strains, and fungicidal activity was demonstrated. Positive interaction between L. luisieri EO combined with terbinafine was observed against terbinafine-resistant strain (Tr ATCC MYA-4438). Significative reduction of the germination was observed above 100 μg mL-1. Both oils were safe to macrophage mammalian cells at tested concentration. This study describes the antifungal activity of L. luisieri and C. citratus EOs against dermatophytes, which could be useful in designing new formulations for topical treatments. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/27309978/Oxygenated_monoterpenes_rich_volatile_oils_as_potential_antifungal_agents_for_dermatophytes_ DB - PRIME DP - Unbound Medicine ER -