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Orthostatic-loading-induced transient venous refluxes (day orthostatic loading test), and remedial effect of micronized purified flavonoid fraction in patients with telangiectasia and reticular vein.
Int Angiol. 2017 Apr; 36(2):189-196.IA

Abstract

BACKGROUND

Orthostatic loading can induce transient venous reflux (TVR). Among patients with telangiectasia and reticular varices, we determined the proportion that developed TVR after a day of orthostatic loading (DOL test), and investigated the remedial effects of micronized purified flavonoid fraction (MPFF).

METHODS

All 96 patients enrolled in this study had telangiectasia and reticular varices. Patients underwent duplex scanning (DS) in the morning and evening, and vein diameters were measured. Patients with detectable evening TVR were treated daily with MPFF (Daflon® 1000 mg; Servier, Suresnes, France) for 90 days, and then reassessed. Patient quality of life (QOL) was evaluated using the Chronic Venous Insufficiency Questionnaire (CIVIQ-20).

RESULTS

At baseline, patients had telangiectasia (45.8%), reticular varices (13.5%), or both (40.7%). TVR was absent in all patients in the morning but present in over half of them (55.2%) in the evening. All TVR patients complained of leg heaviness versus 16.3% of non-TVR patients. The great saphenous vein (GSV) diameters of patients with TVR were significantly greater than those without (Р<0.0001). After MPFF treatment, TVR was eliminated in most patients (92.5%). The GSV diameter in treated patients was significantly reduced from baseline (5.69-5.14 mm; Р=0.000001). The majority of patients (88.6%) no longer experienced leg heaviness, with 11.4% having reduced symptoms. QOL improved.

CONCLUSIONS

More than half of the patients with telangiectasia and reticular varices experience TVR. TVRs can be exposed using the DOL test, which has no impact upon daily life. Daily MPFF (Daflon® 1000 mg) treatment over 90 days eliminated TVR, resolved venous symptoms, and improved QOL.

Authors+Show Affiliations

Department of Surgical Diseases, Omsk State Medical University, Omsk, Russia - yutsokanov@mail.ru.Department of Surgical Diseases, Omsk State Medical University, Omsk, Russia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27314532

Citation

Tsukanov, Yurii T., and Aleksandr I. Nikolaichuk. "Orthostatic-loading-induced Transient Venous Refluxes (day Orthostatic Loading Test), and Remedial Effect of Micronized Purified Flavonoid Fraction in Patients With Telangiectasia and Reticular Vein." International Angiology : a Journal of the International Union of Angiology, vol. 36, no. 2, 2017, pp. 189-196.
Tsukanov YT, Nikolaichuk AI. Orthostatic-loading-induced transient venous refluxes (day orthostatic loading test), and remedial effect of micronized purified flavonoid fraction in patients with telangiectasia and reticular vein. Int Angiol. 2017;36(2):189-196.
Tsukanov, Y. T., & Nikolaichuk, A. I. (2017). Orthostatic-loading-induced transient venous refluxes (day orthostatic loading test), and remedial effect of micronized purified flavonoid fraction in patients with telangiectasia and reticular vein. International Angiology : a Journal of the International Union of Angiology, 36(2), 189-196. https://doi.org/10.23736/S0392-9590.16.03708-1
Tsukanov YT, Nikolaichuk AI. Orthostatic-loading-induced Transient Venous Refluxes (day Orthostatic Loading Test), and Remedial Effect of Micronized Purified Flavonoid Fraction in Patients With Telangiectasia and Reticular Vein. Int Angiol. 2017;36(2):189-196. PubMed PMID: 27314532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Orthostatic-loading-induced transient venous refluxes (day orthostatic loading test), and remedial effect of micronized purified flavonoid fraction in patients with telangiectasia and reticular vein. AU - Tsukanov,Yurii T, AU - Nikolaichuk,Aleksandr I, Y1 - 2016/06/17/ PY - 2016/6/18/pubmed PY - 2017/9/16/medline PY - 2016/6/18/entrez SP - 189 EP - 196 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 36 IS - 2 N2 - BACKGROUND: Orthostatic loading can induce transient venous reflux (TVR). Among patients with telangiectasia and reticular varices, we determined the proportion that developed TVR after a day of orthostatic loading (DOL test), and investigated the remedial effects of micronized purified flavonoid fraction (MPFF). METHODS: All 96 patients enrolled in this study had telangiectasia and reticular varices. Patients underwent duplex scanning (DS) in the morning and evening, and vein diameters were measured. Patients with detectable evening TVR were treated daily with MPFF (Daflon® 1000 mg; Servier, Suresnes, France) for 90 days, and then reassessed. Patient quality of life (QOL) was evaluated using the Chronic Venous Insufficiency Questionnaire (CIVIQ-20). RESULTS: At baseline, patients had telangiectasia (45.8%), reticular varices (13.5%), or both (40.7%). TVR was absent in all patients in the morning but present in over half of them (55.2%) in the evening. All TVR patients complained of leg heaviness versus 16.3% of non-TVR patients. The great saphenous vein (GSV) diameters of patients with TVR were significantly greater than those without (Р<0.0001). After MPFF treatment, TVR was eliminated in most patients (92.5%). The GSV diameter in treated patients was significantly reduced from baseline (5.69-5.14 mm; Р=0.000001). The majority of patients (88.6%) no longer experienced leg heaviness, with 11.4% having reduced symptoms. QOL improved. CONCLUSIONS: More than half of the patients with telangiectasia and reticular varices experience TVR. TVRs can be exposed using the DOL test, which has no impact upon daily life. Daily MPFF (Daflon® 1000 mg) treatment over 90 days eliminated TVR, resolved venous symptoms, and improved QOL. SN - 1827-1839 UR - https://www.unboundmedicine.com/medline/citation/27314532/Orthostatic_loading_induced_transient_venous_refluxes__day_orthostatic_loading_test__and_remedial_effect_of_micronized_purified_flavonoid_fraction_in_patients_with_telangiectasia_and_reticular_vein_ L2 - https://www.minervamedica.it/index2.t?show=R34Y2017N02A0189 DB - PRIME DP - Unbound Medicine ER -