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Association of Vasomotor and Other Menopausal Symptoms with Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis.
PLoS One 2016; 11(6):e0157417Plos

Abstract

IMPORTANCE

Vasomotor symptoms (hot flushes and night sweats) and other symptoms, including depression, anxiety and panic attacks, are commonly experienced by menopausal women and have been associated with an unfavourable cardiovascular risk profile.

OBJECTIVE

To investigate whether presence of menopausal symptoms is associated with the development of cardiovascular disease (CVD).

METHODS

Five electronic databases (Medline, EMBASE and Web of Science) were search until February 17th, 2015 to identify relevant studies. Observational cohort studies or randomised intervention studies were eligible for inclusion if they followed participants prospectively (at least 1 year of follow-up), and reported relevant estimates on the association of any vasomotor symptoms, or other menopausal symptoms, with risk of CVD, coronary heart disease (CHD), or stroke in perimenopausal, menopausal, or postmenopausal women. Data were extracted by two independent reviewers using a pre-designed data collection form. Separate pooled relative risks (RRs) for age and non-established cardiovascular risk factors (e.g., education, ethnicity) adjusted data and for established cardiovascular risk factors and potential mediators-adjusted data (e.g., smoking, body mass index, and hypertension) were calculated.

RESULTS

Out of 9,987 initially identified references, ten studies were selected, including 213,976 women with a total of 10,037 cardiovascular disease outcomes. The age and non-established cardiovascular risk factors adjusted RRs) [95% confidence intervals] for development of CHD, Stroke and CVD comparing women with and without any menopausal symptoms were 1.34 [1.13-1.58], 1.30 [0.99-1.70], 1.48 [1.21-1.80] respectively, and the corresponding RRs adjusted for cardiovascular risk factors and potential mediators were 1.18 [1.03-1.35], 1.08 [0.89-1.32], 1.29 [0.98-1.71]. However, these analyses were limited by potential unmeasured confounding and the small number of studies on this topic.

CONCLUSION

Presence of vasomotor symptoms and other menopausal symptoms are generally associated with an increased risk of cardiovascular disease, which is mainly explained by cardiovascular risk factors.

Authors+Show Affiliations

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.Department of Public Health & Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, United Kingdom.Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.Department of Public Health & Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, United Kingdom.Department of Public Health & Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, United Kingdom.Department of Public Health & Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, United Kingdom.Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27315068

Citation

Muka, Taulant, et al. "Association of Vasomotor and Other Menopausal Symptoms With Risk of Cardiovascular Disease: a Systematic Review and Meta-Analysis." PloS One, vol. 11, no. 6, 2016, pp. e0157417.
Muka T, Oliver-Williams C, Colpani V, et al. Association of Vasomotor and Other Menopausal Symptoms with Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis. PLoS ONE. 2016;11(6):e0157417.
Muka, T., Oliver-Williams, C., Colpani, V., Kunutsor, S., Chowdhury, S., Chowdhury, R., ... Franco, O. H. (2016). Association of Vasomotor and Other Menopausal Symptoms with Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis. PloS One, 11(6), pp. e0157417. doi:10.1371/journal.pone.0157417.
Muka T, et al. Association of Vasomotor and Other Menopausal Symptoms With Risk of Cardiovascular Disease: a Systematic Review and Meta-Analysis. PLoS ONE. 2016;11(6):e0157417. PubMed PMID: 27315068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Vasomotor and Other Menopausal Symptoms with Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis. AU - Muka,Taulant, AU - Oliver-Williams,Clare, AU - Colpani,Veronica, AU - Kunutsor,Setor, AU - Chowdhury,Susmita, AU - Chowdhury,Rajiv, AU - Kavousi,Maryam, AU - Franco,Oscar H, Y1 - 2016/06/17/ PY - 2016/01/29/received PY - 2016/05/31/accepted PY - 2016/6/18/entrez PY - 2016/6/18/pubmed PY - 2017/7/14/medline SP - e0157417 EP - e0157417 JF - PloS one JO - PLoS ONE VL - 11 IS - 6 N2 - IMPORTANCE: Vasomotor symptoms (hot flushes and night sweats) and other symptoms, including depression, anxiety and panic attacks, are commonly experienced by menopausal women and have been associated with an unfavourable cardiovascular risk profile. OBJECTIVE: To investigate whether presence of menopausal symptoms is associated with the development of cardiovascular disease (CVD). METHODS: Five electronic databases (Medline, EMBASE and Web of Science) were search until February 17th, 2015 to identify relevant studies. Observational cohort studies or randomised intervention studies were eligible for inclusion if they followed participants prospectively (at least 1 year of follow-up), and reported relevant estimates on the association of any vasomotor symptoms, or other menopausal symptoms, with risk of CVD, coronary heart disease (CHD), or stroke in perimenopausal, menopausal, or postmenopausal women. Data were extracted by two independent reviewers using a pre-designed data collection form. Separate pooled relative risks (RRs) for age and non-established cardiovascular risk factors (e.g., education, ethnicity) adjusted data and for established cardiovascular risk factors and potential mediators-adjusted data (e.g., smoking, body mass index, and hypertension) were calculated. RESULTS: Out of 9,987 initially identified references, ten studies were selected, including 213,976 women with a total of 10,037 cardiovascular disease outcomes. The age and non-established cardiovascular risk factors adjusted RRs) [95% confidence intervals] for development of CHD, Stroke and CVD comparing women with and without any menopausal symptoms were 1.34 [1.13-1.58], 1.30 [0.99-1.70], 1.48 [1.21-1.80] respectively, and the corresponding RRs adjusted for cardiovascular risk factors and potential mediators were 1.18 [1.03-1.35], 1.08 [0.89-1.32], 1.29 [0.98-1.71]. However, these analyses were limited by potential unmeasured confounding and the small number of studies on this topic. CONCLUSION: Presence of vasomotor symptoms and other menopausal symptoms are generally associated with an increased risk of cardiovascular disease, which is mainly explained by cardiovascular risk factors. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27315068/Association_of_Vasomotor_and_Other_Menopausal_Symptoms_with_Risk_of_Cardiovascular_Disease:_A_Systematic_Review_and_Meta_Analysis_ L2 - http://dx.plos.org/10.1371/journal.pone.0157417 DB - PRIME DP - Unbound Medicine ER -