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Ag nanoclusters could efficiently quench the photoresponse of CdS quantum dots for novel energy transfer-based photoelectrochemical bioanalysis.
Biosens Bioelectron. 2016 Nov 15; 85:930-934.BB

Abstract

Herein the influence of ultrasmall Ag nanoclusters (Ag NCs) against CdS quantum dots (QDs) in a photoelectrochemical (PEC) nanosystem was exploited for the first time, based on which a novel PEC bioanalysis was successfully developed via the efficient quenching effect of Ag NCs against the CdS QDs. In a model system, DNA assay was achieved by using molecular beacon (MB) probes anchored on a CdS QDs modified electrode, and the MB probes contain two segments that can hybridize with both target DNA sequence and the label of DNA encapsulated Ag NCs. After the MB probe was unfolded by the target DNA sequence, the labels of oligonucleotide encapsulated Ag NCs would be brought in close proximity to the CdS QDs electrode surface, and efficient photocurrent quenching of QDs could be resulted from an energy transfer process that originated from NCs. Thus, by monitoring the attenuation in the photocurrent signal, an elegant and sensitive PEC DNA bioanalysis could be accomplished. The developed biosensor displayed a linear range from 1.0pM to 10nM and the detection limit was experimentally found to be of 0.3pM. This work presents a feasible signaling principle that could act as a common basis for general PEC bioanalysis development.

Authors+Show Affiliations

School of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China; State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.School of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China. Electronic address: liangyy403@126.com.School of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China.State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. Electronic address: zww@nju.edu.cn.State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27315518

Citation

Zhang, Ling, et al. "Ag Nanoclusters Could Efficiently Quench the Photoresponse of CdS Quantum Dots for Novel Energy Transfer-based Photoelectrochemical Bioanalysis." Biosensors & Bioelectronics, vol. 85, 2016, pp. 930-934.
Zhang L, Sun Y, Liang YY, et al. Ag nanoclusters could efficiently quench the photoresponse of CdS quantum dots for novel energy transfer-based photoelectrochemical bioanalysis. Biosens Bioelectron. 2016;85:930-934.
Zhang, L., Sun, Y., Liang, Y. Y., He, J. P., Zhao, W. W., Xu, J. J., & Chen, H. Y. (2016). Ag nanoclusters could efficiently quench the photoresponse of CdS quantum dots for novel energy transfer-based photoelectrochemical bioanalysis. Biosensors & Bioelectronics, 85, 930-934. https://doi.org/10.1016/j.bios.2016.06.018
Zhang L, et al. Ag Nanoclusters Could Efficiently Quench the Photoresponse of CdS Quantum Dots for Novel Energy Transfer-based Photoelectrochemical Bioanalysis. Biosens Bioelectron. 2016 Nov 15;85:930-934. PubMed PMID: 27315518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ag nanoclusters could efficiently quench the photoresponse of CdS quantum dots for novel energy transfer-based photoelectrochemical bioanalysis. AU - Zhang,Ling, AU - Sun,Yue, AU - Liang,Yan-Yu, AU - He,Jian-Ping, AU - Zhao,Wei-Wei, AU - Xu,Jing-Juan, AU - Chen,Hong-Yuan, Y1 - 2016/06/08/ PY - 2016/04/16/received PY - 2016/05/26/revised PY - 2016/06/07/accepted PY - 2016/6/18/entrez PY - 2016/6/18/pubmed PY - 2017/2/9/medline KW - Bioanalysis KW - Energy transfer KW - Nanoclusters KW - Photoelectrochemical KW - Quantum dots SP - 930 EP - 934 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 85 N2 - Herein the influence of ultrasmall Ag nanoclusters (Ag NCs) against CdS quantum dots (QDs) in a photoelectrochemical (PEC) nanosystem was exploited for the first time, based on which a novel PEC bioanalysis was successfully developed via the efficient quenching effect of Ag NCs against the CdS QDs. In a model system, DNA assay was achieved by using molecular beacon (MB) probes anchored on a CdS QDs modified electrode, and the MB probes contain two segments that can hybridize with both target DNA sequence and the label of DNA encapsulated Ag NCs. After the MB probe was unfolded by the target DNA sequence, the labels of oligonucleotide encapsulated Ag NCs would be brought in close proximity to the CdS QDs electrode surface, and efficient photocurrent quenching of QDs could be resulted from an energy transfer process that originated from NCs. Thus, by monitoring the attenuation in the photocurrent signal, an elegant and sensitive PEC DNA bioanalysis could be accomplished. The developed biosensor displayed a linear range from 1.0pM to 10nM and the detection limit was experimentally found to be of 0.3pM. This work presents a feasible signaling principle that could act as a common basis for general PEC bioanalysis development. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/27315518/Ag_nanoclusters_could_efficiently_quench_the_photoresponse_of_CdS_quantum_dots_for_novel_energy_transfer_based_photoelectrochemical_bioanalysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(16)30552-8 DB - PRIME DP - Unbound Medicine ER -