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Left ventricular dysfunction in repaired tetralogy of Fallot: incidence and impact on atrial arrhythmias at long term-follow up.
Int J Cardiovasc Imaging. 2016 Sep; 32(9):1441-1449.IJ

Abstract

Left ventricle (LV) systolic dysfunction in repaired tetralogy of Fallot (TOF) has been identified as a risk factor for functional status and adverse outcome. The aims of this cross-sectional followed by a prospective study were: (1) to evaluate the prevalence of LV systolic dysfunction in a large cohort of adults with repaired tetralogy of Fallot, (2) to test the relationship between LV systolic dysfunction and other known risk factors and (3) to evaluate the impact of LV systolic dysfunction on adverse cardiac events. In a multicenter study, 237 adults repaired TOF (58 % males, age 30 ± 10 years) were evaluated by cardiac magnetic resonance (CMR). Demographics, surgical history, ECG, Echo-Color Doppler and follow-up data were recorded. LV was dilated (Z value >2) in 16 patients (6 %), however 56 patients (23.6 %) had a reduced LV systolic function left ventricle ejection fraction (LVEF) (Z value <-2). Patients with LV systolic dysfunction were mainly males (82 %), had reduced right ventricle ejection fraction (RVEF), and higher right and left Late Gadolinium Enhanced scores. In a multivariate regression analysis male gender and RVEF resulted to be independent factors associated to LV systolic dysfunction. Atrial arrhythmias were the main adverse cardiac event at the follow-up and were associated to higher biventricular volumes and lower biventricular ejection fraction (EF); however multivariable analysis identified age, right ventricle end-diastolic volume (RVEDVi) and tricuspid regurgitation as independents factors associated to atrial arrhythmias. At long term follow-up at least ¼ of repaired TOF has LV dysfunction. Lower LVEF is associated to male gender and lower RVEF.

Authors+Show Affiliations

Institute of Clinical Physiology, The National Research Council (CNR), Via Aurelia Sud, 54100, Massa-Pisa, Italy. aitlamia@ifc.cnr.it.Pediatric Cardiology Department, Giannina Gaslini Institute, Genova, Italy.Pediatric Cardiology, Department of Cardiology, Regional Hospital S.Maurizio, Bolzano, Italy.Magnetic Resonance, Department of Radiology, Regional Hospital S.Maurizio, Bolzano, Italy.Radiology Department, Giannina Gaslini Institute, Genova, Italy.Institute of Clinical Physiology, The National Research Council (CNR), Via Aurelia Sud, 54100, Massa-Pisa, Italy.Institute of Clinical Physiology, The National Research Council (CNR), Via Aurelia Sud, 54100, Massa-Pisa, Italy.Institute of Clinical Physiology, The National Research Council (CNR), Via Aurelia Sud, 54100, Massa-Pisa, Italy.O.U. Pediatric Cardiology, Ospedale del cuore, Fondazione G. Monasterio-CNR, Regione Toscana, Italy. MR Laboratory, Fondazione G. Monasterio-CNR, Regione Toscana, Italy.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

27318953

Citation

Ait Ali, Lamia, et al. "Left Ventricular Dysfunction in Repaired Tetralogy of Fallot: Incidence and Impact On Atrial Arrhythmias at Long Term-follow Up." The International Journal of Cardiovascular Imaging, vol. 32, no. 9, 2016, pp. 1441-1449.
Ait Ali L, Trocchio G, Crepaz R, et al. Left ventricular dysfunction in repaired tetralogy of Fallot: incidence and impact on atrial arrhythmias at long term-follow up. Int J Cardiovasc Imaging. 2016;32(9):1441-1449.
Ait Ali, L., Trocchio, G., Crepaz, R., Stuefer, J., Stagnaro, N., Siciliano, V., Molinaro, S., Sicari, R., & Festa, P. (2016). Left ventricular dysfunction in repaired tetralogy of Fallot: incidence and impact on atrial arrhythmias at long term-follow up. The International Journal of Cardiovascular Imaging, 32(9), 1441-1449.
Ait Ali L, et al. Left Ventricular Dysfunction in Repaired Tetralogy of Fallot: Incidence and Impact On Atrial Arrhythmias at Long Term-follow Up. Int J Cardiovasc Imaging. 2016;32(9):1441-1449. PubMed PMID: 27318953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Left ventricular dysfunction in repaired tetralogy of Fallot: incidence and impact on atrial arrhythmias at long term-follow up. AU - Ait Ali,Lamia, AU - Trocchio,GianLuca, AU - Crepaz,Roberto, AU - Stuefer,Josef, AU - Stagnaro,Nicola, AU - Siciliano,Valeria, AU - Molinaro,Sabrina, AU - Sicari,Rosa, AU - Festa,Pierluigi, Y1 - 2016/06/18/ PY - 2016/04/27/received PY - 2016/06/13/accepted PY - 2016/10/19/pubmed PY - 2017/4/25/medline PY - 2016/6/20/entrez KW - Cardiac magnetic resonance KW - Left ventricular dysfunction KW - Tetralogy of Fallot SP - 1441 EP - 1449 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 32 IS - 9 N2 - Left ventricle (LV) systolic dysfunction in repaired tetralogy of Fallot (TOF) has been identified as a risk factor for functional status and adverse outcome. The aims of this cross-sectional followed by a prospective study were: (1) to evaluate the prevalence of LV systolic dysfunction in a large cohort of adults with repaired tetralogy of Fallot, (2) to test the relationship between LV systolic dysfunction and other known risk factors and (3) to evaluate the impact of LV systolic dysfunction on adverse cardiac events. In a multicenter study, 237 adults repaired TOF (58 % males, age 30 ± 10 years) were evaluated by cardiac magnetic resonance (CMR). Demographics, surgical history, ECG, Echo-Color Doppler and follow-up data were recorded. LV was dilated (Z value >2) in 16 patients (6 %), however 56 patients (23.6 %) had a reduced LV systolic function left ventricle ejection fraction (LVEF) (Z value <-2). Patients with LV systolic dysfunction were mainly males (82 %), had reduced right ventricle ejection fraction (RVEF), and higher right and left Late Gadolinium Enhanced scores. In a multivariate regression analysis male gender and RVEF resulted to be independent factors associated to LV systolic dysfunction. Atrial arrhythmias were the main adverse cardiac event at the follow-up and were associated to higher biventricular volumes and lower biventricular ejection fraction (EF); however multivariable analysis identified age, right ventricle end-diastolic volume (RVEDVi) and tricuspid regurgitation as independents factors associated to atrial arrhythmias. At long term follow-up at least ¼ of repaired TOF has LV dysfunction. Lower LVEF is associated to male gender and lower RVEF. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/27318953/Left_ventricular_dysfunction_in_repaired_tetralogy_of_Fallot:_incidence_and_impact_on_atrial_arrhythmias_at_long_term_follow_up_ L2 - https://doi.org/10.1007/s10554-016-0928-7 DB - PRIME DP - Unbound Medicine ER -