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Physical Activity and the Risk of Gallstone Disease: A Systematic Review and Meta-analysis.
J Clin Gastroenterol. 2017 Oct; 51(9):857-868.JC

Abstract

BACKGROUND

The role of physical activity in preventing gallstone disease independent of its effect on the body weight has not been well established. We performed a systematic review and meta-analysis of cohort and case-control studies to analyze this potential association.

METHODS

We searched PubMed and EMBASE to identify all published studies in English through April 2016. We pooled the relative risks (RRs) or odds ratios (ORs) and corresponding 95% confidence intervals (CIs) from individual studies using a random-effects model to investigate associations between physical activity and the risk of gallstone disease.

RESULTS

A total of 16 studies comprising 19 independent reports of approximately 260,000 participants met the inclusion criteria, including 6 case-control studies and 13 cohort studies. In a pooled analysis of cohort studies, physical activity (in a comparison of the highest-level and the lowest-level groups) was associated with a reduced risk of gallstone disease (RR=0.85; 95% CI, 0.78-0.92; I=79.5%). For men, the RR was 0.76 (95% CI, 0.60-0.97), and for women, the RR was similar (RR=0.77; 95% CI, 0.66-0.91). In a dose-response analysis, the RR of gallstone disease was 0.87 (95% CI, 0.83-0.92; I=1.0%) per 20 metabolic equivalent-hours of recreational physical per week. In comparison, case-control studies yielded a stronger significant risk reduction for gallstone disease (OR=0.64; 95% CI, 0.46-0.90; I=76.6%).

CONCLUSIONS

This study suggests an inverse association between physical activity and gallstone disease in both men and women; however, these findings should be interpreted cautiously because of study heterogeneity.

Authors+Show Affiliations

Department of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary and Pancreatic Diseases, Zhengzhou University, The First Affiliated Hospital of Zhengzhou University, School of Medicine, Zhengzhou, P.R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27322529

Citation

Zhang, Yan-Peng, et al. "Physical Activity and the Risk of Gallstone Disease: a Systematic Review and Meta-analysis." Journal of Clinical Gastroenterology, vol. 51, no. 9, 2017, pp. 857-868.
Zhang YP, Zhao YL, Sun YL, et al. Physical Activity and the Risk of Gallstone Disease: A Systematic Review and Meta-analysis. J Clin Gastroenterol. 2017;51(9):857-868.
Zhang, Y. P., Zhao, Y. L., Sun, Y. L., Zhu, R. T., Wang, W. J., & Li, J. (2017). Physical Activity and the Risk of Gallstone Disease: A Systematic Review and Meta-analysis. Journal of Clinical Gastroenterology, 51(9), 857-868. https://doi.org/10.1097/MCG.0000000000000571
Zhang YP, et al. Physical Activity and the Risk of Gallstone Disease: a Systematic Review and Meta-analysis. J Clin Gastroenterol. 2017;51(9):857-868. PubMed PMID: 27322529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical Activity and the Risk of Gallstone Disease: A Systematic Review and Meta-analysis. AU - Zhang,Yan-Peng, AU - Zhao,Ya-Lei, AU - Sun,Yu-Ling, AU - Zhu,Rong-Tao, AU - Wang,Wei-Jie, AU - Li,Jian, PY - 2016/6/21/pubmed PY - 2018/5/22/medline PY - 2016/6/21/entrez SP - 857 EP - 868 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 51 IS - 9 N2 - BACKGROUND: The role of physical activity in preventing gallstone disease independent of its effect on the body weight has not been well established. We performed a systematic review and meta-analysis of cohort and case-control studies to analyze this potential association. METHODS: We searched PubMed and EMBASE to identify all published studies in English through April 2016. We pooled the relative risks (RRs) or odds ratios (ORs) and corresponding 95% confidence intervals (CIs) from individual studies using a random-effects model to investigate associations between physical activity and the risk of gallstone disease. RESULTS: A total of 16 studies comprising 19 independent reports of approximately 260,000 participants met the inclusion criteria, including 6 case-control studies and 13 cohort studies. In a pooled analysis of cohort studies, physical activity (in a comparison of the highest-level and the lowest-level groups) was associated with a reduced risk of gallstone disease (RR=0.85; 95% CI, 0.78-0.92; I=79.5%). For men, the RR was 0.76 (95% CI, 0.60-0.97), and for women, the RR was similar (RR=0.77; 95% CI, 0.66-0.91). In a dose-response analysis, the RR of gallstone disease was 0.87 (95% CI, 0.83-0.92; I=1.0%) per 20 metabolic equivalent-hours of recreational physical per week. In comparison, case-control studies yielded a stronger significant risk reduction for gallstone disease (OR=0.64; 95% CI, 0.46-0.90; I=76.6%). CONCLUSIONS: This study suggests an inverse association between physical activity and gallstone disease in both men and women; however, these findings should be interpreted cautiously because of study heterogeneity. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/27322529/Physical_Activity_and_the_Risk_of_Gallstone_Disease:_A_Systematic_Review_and_Meta_analysis_ L2 - https://doi.org/10.1097/MCG.0000000000000571 DB - PRIME DP - Unbound Medicine ER -