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A new C20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens.
Nat Prod Res. 2017 Mar; 31(5):523-528.NP

Abstract

A new denudatine-type C20-diterpenoid alkaloid, pubesine (1), along with seven known diterpenoid alkaloids, altaconitine (2), 14-benzoylaconine (3), spicatine A (4), 14-benzoylaconine-8-palmitate (5), 14-O-acetylsenbusine A (6), senbusine A (7) and 14-acetylneoline (8) were isolated from the whole plant of Aconitum soongaricum var. pubescens. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against H460, MCF-7 and Hep G2 human cancer cell lines.

Authors+Show Affiliations

a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China. b Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering , Southwest Jiaotong University , Chengdu , China. c School of Chemistry and Chemical Engineering , China West Normal University , Nanchong , China.a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China. b Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering , Southwest Jiaotong University , Chengdu , China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27328130

Citation

Chen, Lin, et al. "A New C20-diterpenoid Alkaloid From Aconitum Soongaricum Var. Pubescens." Natural Product Research, vol. 31, no. 5, 2017, pp. 523-528.
Chen L, Shan L, Xu W, et al. A new C20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens. Nat Prod Res. 2017;31(5):523-528.
Chen, L., Shan, L., Xu, W., Zhang, J., Huang, S., & Zhou, X. (2017). A new C20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens. Natural Product Research, 31(5), 523-528. https://doi.org/10.1080/14786419.2016.1198348
Chen L, et al. A New C20-diterpenoid Alkaloid From Aconitum Soongaricum Var. Pubescens. Nat Prod Res. 2017;31(5):523-528. PubMed PMID: 27328130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new C20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens. AU - Chen,Lin, AU - Shan,Lianhai, AU - Xu,Wenliang, AU - Zhang,Jifa, AU - Huang,Shuai, AU - Zhou,Xianli, Y1 - 2016/06/21/ PY - 2016/6/22/pubmed PY - 2017/4/18/medline PY - 2016/6/22/entrez KW - Aconitum soongaricum var. pubescens KW - Diterpenoid alkaloid KW - cytotoxic activity KW - pubesine SP - 523 EP - 528 JF - Natural product research JO - Nat Prod Res VL - 31 IS - 5 N2 - A new denudatine-type C20-diterpenoid alkaloid, pubesine (1), along with seven known diterpenoid alkaloids, altaconitine (2), 14-benzoylaconine (3), spicatine A (4), 14-benzoylaconine-8-palmitate (5), 14-O-acetylsenbusine A (6), senbusine A (7) and 14-acetylneoline (8) were isolated from the whole plant of Aconitum soongaricum var. pubescens. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against H460, MCF-7 and Hep G2 human cancer cell lines. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/27328130/A_new_C20_diterpenoid_alkaloid_from_Aconitum_soongaricum_var__pubescens_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2016.1198348 DB - PRIME DP - Unbound Medicine ER -