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The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis.
Clin Exp Obstet Gynecol. 2016; 43(3):463-6.CE

Abstract

OBJECTIVE

Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in normal endometrium and in ectopic endometriotic tissues.

MATERIALS AND METHODS

Nectin-4 expression was investigated in ovarian endometriosis (n = 20), peritoneal endometriosis (n = 20), endometrium of endometriosis (n = 20), and in a control group (having no endometriosis) (n = 20) by immunohistochemical method.

RESULTS

Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 and p = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011).

CONCLUSION

The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27328518

Citation

Bedir, R, et al. "The Role of the Adhesion Molecule Nectin-4 in the Pathogenesis of Endometriosis." Clinical and Experimental Obstetrics & Gynecology, vol. 43, no. 3, 2016, pp. 463-6.
Bedir R, Sehitoglu I, Balik G, et al. The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis. Clin Exp Obstet Gynecol. 2016;43(3):463-6.
Bedir, R., Sehitoglu, I., Balik, G., Kagitci, M., Gucer, H., Yurdakul, C., & Bagci, P. (2016). The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis. Clinical and Experimental Obstetrics & Gynecology, 43(3), 463-6.
Bedir R, et al. The Role of the Adhesion Molecule Nectin-4 in the Pathogenesis of Endometriosis. Clin Exp Obstet Gynecol. 2016;43(3):463-6. PubMed PMID: 27328518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis. AU - Bedir,R, AU - Sehitoglu,I, AU - Balik,G, AU - Kagitci,M, AU - Gucer,H, AU - Yurdakul,C, AU - Bagci,P, PY - 2016/6/23/entrez PY - 2016/6/23/pubmed PY - 2016/7/29/medline SP - 463 EP - 6 JF - Clinical and experimental obstetrics & gynecology JO - Clin Exp Obstet Gynecol VL - 43 IS - 3 N2 - OBJECTIVE: Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in normal endometrium and in ectopic endometriotic tissues. MATERIALS AND METHODS: Nectin-4 expression was investigated in ovarian endometriosis (n = 20), peritoneal endometriosis (n = 20), endometrium of endometriosis (n = 20), and in a control group (having no endometriosis) (n = 20) by immunohistochemical method. RESULTS: Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 and p = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011). CONCLUSION: The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful. SN - 0390-6663 UR - https://www.unboundmedicine.com/medline/citation/27328518/The_role_of_the_adhesion_molecule_Nectin_4_in_the_pathogenesis_of_endometriosis_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -