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Association of vitamin D receptor gene TaqI, BsmI, FokI and ApaI polymorphisms and susceptibility to extremity chronic osteomyelitis in Chinese population.
Injury. 2016 Aug; 47(8):1655-60.I

Abstract

Previous studies have indicated that vitamin D receptor (VDR) TaqI, BsmI, FokI and ApaI gene polymorphisms are associated with the risk of several inflammatory diseases. However, potential association of the VDR gene polymorphisms with susceptibility to extremity chronic osteomyelitis remains unclear. The present study aimed to investigate link between VDR gene polymorphisms and the risk of extremity chronic osteomyelitis in Chinese population. A total of 233 patients with chronic osteomyelitis and 200 healthy controls were genotyped for the 4 single-nucleotide polymorphisms (SNPs) (TaqI, BsmI, FokI and ApaI) in VDR gene using the SNaPshot genotyping method. The frequencies of mutant allele C in rs731236 (P=0.044, OR=1.830, 95% CI 1.009 - 3.319) and rs2228570 (P=0.029, OR=1.347, 95% CI 1.031 - 1.761) were significantly higher in patients than those in healthy controls. In addition, outcomes of the logistic regression analysis adjusted by gender and age revealed that significant links were found between rs731236 (P=0.05, OR=1.887, 95% CI 1.001 - 3.558), rs2228570 (P=0.042, OR=1.594, 95% CI 1.016-2.500) and the risk of developing chronic osteomyelitis by dominant genetic model. In addition, significant association was also found between rs2228570 and the risk of developing the disease by homozygous model (P=0.034, OR=1.803, 95% CI 1.046 - 3.106). However, no significant correlations were found between BsmI (rs1544410) or ApaI (rs7975232) gene polymorphisms and the susceptibility to the disease. To our knowledge, we reported for the first time that VDR gene TaqI (rs731236) and FokI (rs2228570) polymorphisms may contribute to the increased risk of chronic osteomyelitis in Chinese population.

Authors+Show Affiliations

Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China; Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China. Electronic address: smuyubin@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27329975

Citation

Jiang, Nan, et al. "Association of Vitamin D Receptor Gene TaqI, BsmI, FokI and ApaI Polymorphisms and Susceptibility to Extremity Chronic Osteomyelitis in Chinese Population." Injury, vol. 47, no. 8, 2016, pp. 1655-60.
Jiang N, Zhao XQ, Qin CH, et al. Association of vitamin D receptor gene TaqI, BsmI, FokI and ApaI polymorphisms and susceptibility to extremity chronic osteomyelitis in Chinese population. Injury. 2016;47(8):1655-60.
Jiang, N., Zhao, X. Q., Qin, C. H., Hu, Y. J., Wang, L., Xie, G. P., Wang, S. N., Chen, L. G., & Yu, B. (2016). Association of vitamin D receptor gene TaqI, BsmI, FokI and ApaI polymorphisms and susceptibility to extremity chronic osteomyelitis in Chinese population. Injury, 47(8), 1655-60. https://doi.org/10.1016/j.injury.2016.06.005
Jiang N, et al. Association of Vitamin D Receptor Gene TaqI, BsmI, FokI and ApaI Polymorphisms and Susceptibility to Extremity Chronic Osteomyelitis in Chinese Population. Injury. 2016;47(8):1655-60. PubMed PMID: 27329975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of vitamin D receptor gene TaqI, BsmI, FokI and ApaI polymorphisms and susceptibility to extremity chronic osteomyelitis in Chinese population. AU - Jiang,Nan, AU - Zhao,Xing-Qi, AU - Qin,Cheng-He, AU - Hu,Yan-Jun, AU - Wang,Lei, AU - Xie,Guo-Ping, AU - Wang,Sheng-Nan, AU - Chen,Li-Guang, AU - Yu,Bin, Y1 - 2016/06/04/ PY - 2016/01/22/received PY - 2016/05/31/revised PY - 2016/06/02/accepted PY - 2016/6/23/entrez PY - 2016/6/23/pubmed PY - 2017/9/12/medline KW - Chronic osteomyelitis KW - SNaPshot KW - Single-nucleotide polymorphism KW - Vitamin D receptor (VDR) gene KW - rs2228570 KW - rs731236 SP - 1655 EP - 60 JF - Injury JO - Injury VL - 47 IS - 8 N2 - Previous studies have indicated that vitamin D receptor (VDR) TaqI, BsmI, FokI and ApaI gene polymorphisms are associated with the risk of several inflammatory diseases. However, potential association of the VDR gene polymorphisms with susceptibility to extremity chronic osteomyelitis remains unclear. The present study aimed to investigate link between VDR gene polymorphisms and the risk of extremity chronic osteomyelitis in Chinese population. A total of 233 patients with chronic osteomyelitis and 200 healthy controls were genotyped for the 4 single-nucleotide polymorphisms (SNPs) (TaqI, BsmI, FokI and ApaI) in VDR gene using the SNaPshot genotyping method. The frequencies of mutant allele C in rs731236 (P=0.044, OR=1.830, 95% CI 1.009 - 3.319) and rs2228570 (P=0.029, OR=1.347, 95% CI 1.031 - 1.761) were significantly higher in patients than those in healthy controls. In addition, outcomes of the logistic regression analysis adjusted by gender and age revealed that significant links were found between rs731236 (P=0.05, OR=1.887, 95% CI 1.001 - 3.558), rs2228570 (P=0.042, OR=1.594, 95% CI 1.016-2.500) and the risk of developing chronic osteomyelitis by dominant genetic model. In addition, significant association was also found between rs2228570 and the risk of developing the disease by homozygous model (P=0.034, OR=1.803, 95% CI 1.046 - 3.106). However, no significant correlations were found between BsmI (rs1544410) or ApaI (rs7975232) gene polymorphisms and the susceptibility to the disease. To our knowledge, we reported for the first time that VDR gene TaqI (rs731236) and FokI (rs2228570) polymorphisms may contribute to the increased risk of chronic osteomyelitis in Chinese population. SN - 1879-0267 UR - https://www.unboundmedicine.com/medline/citation/27329975/Association_of_vitamin_D_receptor_gene_TaqI_BsmI_FokI_and_ApaI_polymorphisms_and_susceptibility_to_extremity_chronic_osteomyelitis_in_Chinese_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0020-1383(16)30223-6 DB - PRIME DP - Unbound Medicine ER -