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Electrical status epilepticus in sleep (ESES)/continuous spikes and waves during slow sleep (CSWS) syndrome in children: An electroclinical evaluation according to the EEG patterns.
Epilepsy Behav. 2016 08; 61:107-111.EB

Abstract

OBJECTIVE

The aim of this study was to describe the electroclinical spectrum in children with electrical status epilepticus in sleep (ESES)/continuous spikes and waves during slow sleep (CSWS) syndrome according to the EEG patterns.

METHODS

Clinical data of 44 patients with ESES/CSWS syndrome who were treated and followed at least two years were analyzed. Records of EEGs of patients were reevaluated to determine two aspects of the ESES pattern: (1) the spike-wave index (SWI) on the NREM sleep EEG (Group I: typical vs. atypical ESES pattern (33/11 patients)) and (2) the area of maximum amplitude of continuous epileptic activity (Group II: anterior vs. posterior ESES pattern (33/11 patients)).

RESULTS

Symptomatic etiology was more defined in patients with the typical ESES pattern (40%) than the group with the atypical ESES pattern (9%) by a factor of four. All patients were receiving at least two antiepileptic drug (AED) treatments. Eighteen patients (41%) received AEDs plus ACTH therapy. Complete disappearance of the ESES pattern on the EEG was observed in 18 patients (41%), more than 50% reduction was observed in five patients (11%), less than 50% reduction was observed in eight patients (18%), and no response was observed in five patients (11%). No significant difference was found when comparing the groups in terms of reduction of seizures and the SWI. Seizure outcome at the two-year follow-up was similar between the group with ESES treated with AEDs plus ACTH and the group with ESES treated with AEDs without ACTH therapy.

SIGNIFICANCE

This study demonstrated that the rate of the SWI (typical vs. atypical ESES) and the maximum amplitude of the ESES pattern (anterior vs. posterior) have no significant correlation with seizure control and reduction of the SWI on the EEG in children with ESES syndrome.

Authors+Show Affiliations

Tepecik Training and Research Hospital, Department of Pediatric Neurology, Izmir, Turkey. Electronic address: pinargencpinar@yahoo.com.tr.Izmir Katip Çelebi University, Department of Pediatric Neurology, Izmir, Turkey.Ege University Hospital, Department of Pediatric Neurology, Izmir, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27337163

Citation

Gencpinar, Pinar, et al. "Electrical Status Epilepticus in Sleep (ESES)/continuous Spikes and Waves During Slow Sleep (CSWS) Syndrome in Children: an Electroclinical Evaluation According to the EEG Patterns." Epilepsy & Behavior : E&B, vol. 61, 2016, pp. 107-111.
Gencpinar P, Dundar NO, Tekgul H. Electrical status epilepticus in sleep (ESES)/continuous spikes and waves during slow sleep (CSWS) syndrome in children: An electroclinical evaluation according to the EEG patterns. Epilepsy Behav. 2016;61:107-111.
Gencpinar, P., Dundar, N. O., & Tekgul, H. (2016). Electrical status epilepticus in sleep (ESES)/continuous spikes and waves during slow sleep (CSWS) syndrome in children: An electroclinical evaluation according to the EEG patterns. Epilepsy & Behavior : E&B, 61, 107-111. https://doi.org/10.1016/j.yebeh.2016.05.014
Gencpinar P, Dundar NO, Tekgul H. Electrical Status Epilepticus in Sleep (ESES)/continuous Spikes and Waves During Slow Sleep (CSWS) Syndrome in Children: an Electroclinical Evaluation According to the EEG Patterns. Epilepsy Behav. 2016;61:107-111. PubMed PMID: 27337163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrical status epilepticus in sleep (ESES)/continuous spikes and waves during slow sleep (CSWS) syndrome in children: An electroclinical evaluation according to the EEG patterns. AU - Gencpinar,Pinar, AU - Dundar,Nihal Olgac, AU - Tekgul,Hasan, Y1 - 2016/06/21/ PY - 2016/01/27/received PY - 2016/05/12/revised PY - 2016/05/13/accepted PY - 2016/6/24/entrez PY - 2016/6/24/pubmed PY - 2017/9/5/medline KW - Amplitude KW - Continuous spikes and waves during slow sleep (CSWS) KW - Electrical status epilepticus in sleep (ESES) KW - Electroclinical evaluation KW - Electroencephalography (EEG) SP - 107 EP - 111 JF - Epilepsy & behavior : E&B JO - Epilepsy Behav VL - 61 N2 - OBJECTIVE: The aim of this study was to describe the electroclinical spectrum in children with electrical status epilepticus in sleep (ESES)/continuous spikes and waves during slow sleep (CSWS) syndrome according to the EEG patterns. METHODS: Clinical data of 44 patients with ESES/CSWS syndrome who were treated and followed at least two years were analyzed. Records of EEGs of patients were reevaluated to determine two aspects of the ESES pattern: (1) the spike-wave index (SWI) on the NREM sleep EEG (Group I: typical vs. atypical ESES pattern (33/11 patients)) and (2) the area of maximum amplitude of continuous epileptic activity (Group II: anterior vs. posterior ESES pattern (33/11 patients)). RESULTS: Symptomatic etiology was more defined in patients with the typical ESES pattern (40%) than the group with the atypical ESES pattern (9%) by a factor of four. All patients were receiving at least two antiepileptic drug (AED) treatments. Eighteen patients (41%) received AEDs plus ACTH therapy. Complete disappearance of the ESES pattern on the EEG was observed in 18 patients (41%), more than 50% reduction was observed in five patients (11%), less than 50% reduction was observed in eight patients (18%), and no response was observed in five patients (11%). No significant difference was found when comparing the groups in terms of reduction of seizures and the SWI. Seizure outcome at the two-year follow-up was similar between the group with ESES treated with AEDs plus ACTH and the group with ESES treated with AEDs without ACTH therapy. SIGNIFICANCE: This study demonstrated that the rate of the SWI (typical vs. atypical ESES) and the maximum amplitude of the ESES pattern (anterior vs. posterior) have no significant correlation with seizure control and reduction of the SWI on the EEG in children with ESES syndrome. SN - 1525-5069 UR - https://www.unboundmedicine.com/medline/citation/27337163/Electrical_status_epilepticus_in_sleep__ESES_/continuous_spikes_and_waves_during_slow_sleep__CSWS__syndrome_in_children:_An_electroclinical_evaluation_according_to_the_EEG_patterns_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1525-5050(16)30097-X DB - PRIME DP - Unbound Medicine ER -