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Intracellular Calcium Dysregulation: Implications for Alzheimer's Disease.
Biomed Res Int. 2016; 2016:6701324.BR

Abstract

Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive neuronal loss. AD is associated with aberrant processing of the amyloid precursor protein, which leads to the deposition of amyloid-β plaques within the brain. Together with plaques deposition, the hyperphosphorylation of the microtubules associated protein tau and the formation of intraneuronal neurofibrillary tangles are a typical neuropathological feature in AD brains. Cellular dysfunctions involving specific subcellular compartments, such as mitochondria and endoplasmic reticulum (ER), are emerging as crucial players in the pathogenesis of AD, as well as increased oxidative stress and dysregulation of calcium homeostasis. Specifically, dysregulation of intracellular calcium homeostasis has been suggested as a common proximal cause of neural dysfunction in AD. Aberrant calcium signaling has been considered a phenomenon mainly related to the dysfunction of intracellular calcium stores, which can occur in both neuronal and nonneuronal cells. This review reports the most recent findings on cellular mechanisms involved in the pathogenesis of AD, with main focus on the control of calcium homeostasis at both cytosolic and mitochondrial level.

Authors+Show Affiliations

Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", 60126 Ancona, Italy.Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", 60126 Ancona, Italy.Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", 60126 Ancona, Italy.Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", 60126 Ancona, Italy.Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", 60126 Ancona, Italy.Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", 60126 Ancona, Italy.Department of Health Sciences, University "Magna Graecia", 88100 Catanzaro, Italy.Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", 60126 Ancona, Italy.Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", 60126 Ancona, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27340665

Citation

Magi, Simona, et al. "Intracellular Calcium Dysregulation: Implications for Alzheimer's Disease." BioMed Research International, vol. 2016, 2016, p. 6701324.
Magi S, Castaldo P, Macrì ML, et al. Intracellular Calcium Dysregulation: Implications for Alzheimer's Disease. Biomed Res Int. 2016;2016:6701324.
Magi, S., Castaldo, P., Macrì, M. L., Maiolino, M., Matteucci, A., Bastioli, G., Gratteri, S., Amoroso, S., & Lariccia, V. (2016). Intracellular Calcium Dysregulation: Implications for Alzheimer's Disease. BioMed Research International, 2016, 6701324. https://doi.org/10.1155/2016/6701324
Magi S, et al. Intracellular Calcium Dysregulation: Implications for Alzheimer's Disease. Biomed Res Int. 2016;2016:6701324. PubMed PMID: 27340665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intracellular Calcium Dysregulation: Implications for Alzheimer's Disease. AU - Magi,Simona, AU - Castaldo,Pasqualina, AU - Macrì,Maria Loredana, AU - Maiolino,Marta, AU - Matteucci,Alessandra, AU - Bastioli,Guendalina, AU - Gratteri,Santo, AU - Amoroso,Salvatore, AU - Lariccia,Vincenzo, Y1 - 2016/06/02/ PY - 2016/03/23/received PY - 2016/05/15/accepted PY - 2016/6/25/entrez PY - 2016/6/25/pubmed PY - 2017/2/18/medline SP - 6701324 EP - 6701324 JF - BioMed research international JO - Biomed Res Int VL - 2016 N2 - Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive neuronal loss. AD is associated with aberrant processing of the amyloid precursor protein, which leads to the deposition of amyloid-β plaques within the brain. Together with plaques deposition, the hyperphosphorylation of the microtubules associated protein tau and the formation of intraneuronal neurofibrillary tangles are a typical neuropathological feature in AD brains. Cellular dysfunctions involving specific subcellular compartments, such as mitochondria and endoplasmic reticulum (ER), are emerging as crucial players in the pathogenesis of AD, as well as increased oxidative stress and dysregulation of calcium homeostasis. Specifically, dysregulation of intracellular calcium homeostasis has been suggested as a common proximal cause of neural dysfunction in AD. Aberrant calcium signaling has been considered a phenomenon mainly related to the dysfunction of intracellular calcium stores, which can occur in both neuronal and nonneuronal cells. This review reports the most recent findings on cellular mechanisms involved in the pathogenesis of AD, with main focus on the control of calcium homeostasis at both cytosolic and mitochondrial level. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/27340665/Intracellular_Calcium_Dysregulation:_Implications_for_Alzheimer's_Disease_ DB - PRIME DP - Unbound Medicine ER -