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LDL-C/apoB and HDL-C/apoA-1 ratios predict incident chronic kidney disease in a large apparently healthy cohort.
Atherosclerosis. 2016 08; 251:170-176.A

Abstract

BACKGROUND AND AIMS

The objective of this study was to evaluate the ability of lipid variables to predict the development of chronic kidney disease (CKD). We investigated the longitudinal association between lipid profiles and incident CKD in a large apparently healthy cohort.

METHODS

A retrospective longitudinal analysis of 10,288 subjects who had participated in comprehensive health check-ups at least four times over a 7-year period was conducted. The risk of incident CKD associated with lipid variables was analyzed using adjusted hazard ratio (HR) for CKD per 1 standard deviation (SD) increase in lipid level. The development of CKD was defined as estimated glomerular filtration rate <60 ml/min/1.73 m(2).

RESULTS

Over a mean follow-up of 56.5 ± 14.3 months, 356 (3.5%) subjects developed CKD. The multivariate adjusted HRs for incident CKD per 1 SD increase in baseline lipid level were 1.29 (95% confidence interval [CI], 1.17-1.41) for triglycerides (TG), 0.77 (0.68-0.88) for high-density lipoprotein cholesterol (HDL-C), 1.22 (1.12-1.32) for the TG/HDL-C ratio, 0.82 (0.73-0.92) for the low-density lipoprotein cholesterol/apolipoprotein B (LDL-C/apoB) ratio, and 0.74 (0.66-0.83) for the HDL-C/apoA-1 ratio. No longitudinal association was found between incident CKD and baseline total cholesterol, LDL-C, non-HDL-C, the LDL-C/HDL-C ratio, apoB, apoA-I, or the apoB/apoA-I ratio.

CONCLUSIONS

The LDL-C/apoB and HDL-C/apoA-1 ratios as well as TG and HDL-C concentrations independently predicted an increased risk for developing CKD. Our findings suggest that particle size of HDLs and LDLs may contribute to the development of CKD.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, 630-723, Republic of Korea.Division of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, 630-723, Republic of Korea.Division of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, 630-723, Republic of Korea.Department of Health Promotion Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 135-710, Republic of Korea.Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 135-710, Republic of Korea.Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 135-710, Republic of Korea.Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 135-710, Republic of Korea; Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, 135-710, Republic of Korea. Electronic address: jaehyeon@skku.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27341533

Citation

Bae, Ji Cheol, et al. "LDL-C/apoB and HDL-C/apoA-1 Ratios Predict Incident Chronic Kidney Disease in a Large Apparently Healthy Cohort." Atherosclerosis, vol. 251, 2016, pp. 170-176.
Bae JC, Han JM, Kwon S, et al. LDL-C/apoB and HDL-C/apoA-1 ratios predict incident chronic kidney disease in a large apparently healthy cohort. Atherosclerosis. 2016;251:170-176.
Bae, J. C., Han, J. M., Kwon, S., Jee, J. H., Yu, T. Y., Lee, M. K., & Kim, J. H. (2016). LDL-C/apoB and HDL-C/apoA-1 ratios predict incident chronic kidney disease in a large apparently healthy cohort. Atherosclerosis, 251, 170-176. https://doi.org/10.1016/j.atherosclerosis.2016.06.029
Bae JC, et al. LDL-C/apoB and HDL-C/apoA-1 Ratios Predict Incident Chronic Kidney Disease in a Large Apparently Healthy Cohort. Atherosclerosis. 2016;251:170-176. PubMed PMID: 27341533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - LDL-C/apoB and HDL-C/apoA-1 ratios predict incident chronic kidney disease in a large apparently healthy cohort. AU - Bae,Ji Cheol, AU - Han,Ji Min, AU - Kwon,Sam, AU - Jee,Jae Hwan, AU - Yu,Tae Yang, AU - Lee,Moon Kyu, AU - Kim,Jae Hyeon, Y1 - 2016/06/16/ PY - 2016/03/01/received PY - 2016/05/25/revised PY - 2016/06/15/accepted PY - 2016/6/25/entrez PY - 2016/6/25/pubmed PY - 2017/12/27/medline KW - Apolipoprotein KW - Chronic kidney disease KW - Dyslipidemia KW - Estimated glomerular filtration rate KW - Low-density lipoprotein cholesterol KW - Triglycerides to high-density lipoprotein cholesterol ratio SP - 170 EP - 176 JF - Atherosclerosis JO - Atherosclerosis VL - 251 N2 - BACKGROUND AND AIMS: The objective of this study was to evaluate the ability of lipid variables to predict the development of chronic kidney disease (CKD). We investigated the longitudinal association between lipid profiles and incident CKD in a large apparently healthy cohort. METHODS: A retrospective longitudinal analysis of 10,288 subjects who had participated in comprehensive health check-ups at least four times over a 7-year period was conducted. The risk of incident CKD associated with lipid variables was analyzed using adjusted hazard ratio (HR) for CKD per 1 standard deviation (SD) increase in lipid level. The development of CKD was defined as estimated glomerular filtration rate <60 ml/min/1.73 m(2). RESULTS: Over a mean follow-up of 56.5 ± 14.3 months, 356 (3.5%) subjects developed CKD. The multivariate adjusted HRs for incident CKD per 1 SD increase in baseline lipid level were 1.29 (95% confidence interval [CI], 1.17-1.41) for triglycerides (TG), 0.77 (0.68-0.88) for high-density lipoprotein cholesterol (HDL-C), 1.22 (1.12-1.32) for the TG/HDL-C ratio, 0.82 (0.73-0.92) for the low-density lipoprotein cholesterol/apolipoprotein B (LDL-C/apoB) ratio, and 0.74 (0.66-0.83) for the HDL-C/apoA-1 ratio. No longitudinal association was found between incident CKD and baseline total cholesterol, LDL-C, non-HDL-C, the LDL-C/HDL-C ratio, apoB, apoA-I, or the apoB/apoA-I ratio. CONCLUSIONS: The LDL-C/apoB and HDL-C/apoA-1 ratios as well as TG and HDL-C concentrations independently predicted an increased risk for developing CKD. Our findings suggest that particle size of HDLs and LDLs may contribute to the development of CKD. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/27341533/LDL_C/apoB_and_HDL_C/apoA_1_ratios_predict_incident_chronic_kidney_disease_in_a_large_apparently_healthy_cohort_ DB - PRIME DP - Unbound Medicine ER -