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Low insulin-like growth factor 1 is associated with low high-density lipoprotein cholesterol and metabolic syndrome in Chinese nondiabetic obese children and adolescents: a cross-sectional study.
Lipids Health Dis. 2016 Jun 24; 15:112.LH

Abstract

BACKGROUND

Low serum high-density lipoprotein cholesterol (HDL-C) is an independent risk factor for developing cardiovascular disease. Insulin-like growth factor 1(IGF-1) levels have been proven to be positively associated with HDL-C, but few studies were based on the dataset of children or adolescents. The aim of this study is to investigate the relationship among IGF-1, HDL-C and the metabolic syndrome in Chinese nondiabetic obese children and adolescents.

METHODS

As a cross-sectional study, this study includes 120 obese Chinese children and adolescents and 120 healthy ones. The obese subjects were divided into two groups based on using 1.03 mmol/L as a threshold value for HDL-C. Clinical examination and laboratory examinations were assessed for all participants.

RESULTS

Obese subjects had significantly lower IGF-1SDS and higher Height SDS than those in the control group. Among 120 obese children and adolescents, 22 (18.3 %) subjects had an HDL-C level <1.03 mmol/L. IGF-1SDS was significantly lower (P = 0.001) in obese subjects with low HDL-C. According to the results of multivariate logistic regression analysis, IGF-1 SDS is significantly associated with low HDL-C(OR 0.518, 95 % CI 0.292-0.916; P = 0.024), after being adjusted for age, gender, pubertal status, BMI SDS, SBP, DBP, HOMR-IR, total cholesterol, low density lipoprotein-cholesterol, triglycerides, ALT and uric acid. In addition, IGF-1 SDS is significantly correlated with the level of serum HDL-C in study population (r = 0.19, P = 0.003). Based on logistic regression analysis with adjustment for age, gender and pubertal status, the increased IGF-1 SDS was associated with a decreased probability of metabolic syndrome (OR 0.555, 95 % CI 0.385-0.801; P = 0.002) and hypertriglyceridemia (OR 0.582, 95 % CI 0.395-0.856; P = 0.006), but no significant correlation with hypertension.

CONCLUSION

Obese children had lower IGF-1SDS and taller stature compared with the control group. Low levels of IGF-1 SDS were associated with low levels of HDL-C in chinese nondiabetic obese children and adolescents, independent of insulin resistance, as well as other traditional cardiovascular disease risk markers.

Authors+Show Affiliations

Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, 9677 Jingshi Road, Jinan, 250021, China.Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, 9677 Jingshi Road, Jinan, 250021, China.Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, 9677 Jingshi Road, Jinan, 250021, China.Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, 9677 Jingshi Road, Jinan, 250021, China.Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, 9677 Jingshi Road, Jinan, 250021, China. lgmusa05@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27343122

Citation

Liang, Shuang, et al. "Low Insulin-like Growth Factor 1 Is Associated With Low High-density Lipoprotein Cholesterol and Metabolic Syndrome in Chinese Nondiabetic Obese Children and Adolescents: a Cross-sectional Study." Lipids in Health and Disease, vol. 15, 2016, p. 112.
Liang S, Hu Y, Liu C, et al. Low insulin-like growth factor 1 is associated with low high-density lipoprotein cholesterol and metabolic syndrome in Chinese nondiabetic obese children and adolescents: a cross-sectional study. Lipids Health Dis. 2016;15:112.
Liang, S., Hu, Y., Liu, C., Qi, J., & Li, G. (2016). Low insulin-like growth factor 1 is associated with low high-density lipoprotein cholesterol and metabolic syndrome in Chinese nondiabetic obese children and adolescents: a cross-sectional study. Lipids in Health and Disease, 15, 112. https://doi.org/10.1186/s12944-016-0275-7
Liang S, et al. Low Insulin-like Growth Factor 1 Is Associated With Low High-density Lipoprotein Cholesterol and Metabolic Syndrome in Chinese Nondiabetic Obese Children and Adolescents: a Cross-sectional Study. Lipids Health Dis. 2016 Jun 24;15:112. PubMed PMID: 27343122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low insulin-like growth factor 1 is associated with low high-density lipoprotein cholesterol and metabolic syndrome in Chinese nondiabetic obese children and adolescents: a cross-sectional study. AU - Liang,Shuang, AU - Hu,Yanyan, AU - Liu,Caihong, AU - Qi,Jianhong, AU - Li,Guimei, Y1 - 2016/06/24/ PY - 2016/04/22/received PY - 2016/06/15/accepted PY - 2016/6/26/entrez PY - 2016/6/28/pubmed PY - 2017/3/25/medline KW - Children KW - High-density lipoprotein cholesterol KW - Insulin like growth factor 1 KW - Metabolic syndrome KW - Obesity SP - 112 EP - 112 JF - Lipids in health and disease JO - Lipids Health Dis VL - 15 N2 - BACKGROUND: Low serum high-density lipoprotein cholesterol (HDL-C) is an independent risk factor for developing cardiovascular disease. Insulin-like growth factor 1(IGF-1) levels have been proven to be positively associated with HDL-C, but few studies were based on the dataset of children or adolescents. The aim of this study is to investigate the relationship among IGF-1, HDL-C and the metabolic syndrome in Chinese nondiabetic obese children and adolescents. METHODS: As a cross-sectional study, this study includes 120 obese Chinese children and adolescents and 120 healthy ones. The obese subjects were divided into two groups based on using 1.03 mmol/L as a threshold value for HDL-C. Clinical examination and laboratory examinations were assessed for all participants. RESULTS: Obese subjects had significantly lower IGF-1SDS and higher Height SDS than those in the control group. Among 120 obese children and adolescents, 22 (18.3 %) subjects had an HDL-C level <1.03 mmol/L. IGF-1SDS was significantly lower (P = 0.001) in obese subjects with low HDL-C. According to the results of multivariate logistic regression analysis, IGF-1 SDS is significantly associated with low HDL-C(OR 0.518, 95 % CI 0.292-0.916; P = 0.024), after being adjusted for age, gender, pubertal status, BMI SDS, SBP, DBP, HOMR-IR, total cholesterol, low density lipoprotein-cholesterol, triglycerides, ALT and uric acid. In addition, IGF-1 SDS is significantly correlated with the level of serum HDL-C in study population (r = 0.19, P = 0.003). Based on logistic regression analysis with adjustment for age, gender and pubertal status, the increased IGF-1 SDS was associated with a decreased probability of metabolic syndrome (OR 0.555, 95 % CI 0.385-0.801; P = 0.002) and hypertriglyceridemia (OR 0.582, 95 % CI 0.395-0.856; P = 0.006), but no significant correlation with hypertension. CONCLUSION: Obese children had lower IGF-1SDS and taller stature compared with the control group. Low levels of IGF-1 SDS were associated with low levels of HDL-C in chinese nondiabetic obese children and adolescents, independent of insulin resistance, as well as other traditional cardiovascular disease risk markers. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/27343122/Low_insulin_like_growth_factor_1_is_associated_with_low_high_density_lipoprotein_cholesterol_and_metabolic_syndrome_in_Chinese_nondiabetic_obese_children_and_adolescents:_a_cross_sectional_study_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-016-0275-7 DB - PRIME DP - Unbound Medicine ER -