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Graphene/Nafion composite film modified glassy carbon electrode for simultaneous determination of paracetamol, aspirin and caffeine in pharmaceutical formulations.
Talanta. 2016 Sep 01; 158:21-29.T

Abstract

A graphene-Nafion composite film was fabricated on the glassy carbon electrode (GR-NF/GCE), and used for simultaneous determination of paracetamol (PAR), aspirin (ASA) and caffeine (CAF). The electrochemical behaviors of PAR, ASA and CAF were investigated by cyclic voltammetry and square-wave adsorptive anodic stripping voltammetry. By using stripping one for simultaneous determination of PAR, ASA and CAF, their electrochemical oxidation peaks appeared at +0.64, 1.04 and 1.44V, and good linear current responses were obtained with the detection limits of 18ngmL(-1) (1.2×10(-9)M), 11.7ngmL(-1) (6.5×10(-8)M) and 7.3ngmL(-1) (3.8×10(-8)M), respectively. Finally, the proposed electrochemical sensor was successfully applied for quantifying PAR, ASA and CAF in commercial tablet formulations.

Authors+Show Affiliations

Yüzüncü Yıl University, Faculty of Pharmacy, Department of Analytical Chemistry, 65080 Van, Turkey.Yüzüncü Yıl University, Faculty of Pharmacy, Department of Analytical Chemistry, 65080 Van, Turkey. Electronic address: yavuzyardim2002@yahoo.com.Yüzüncü Yıl University, Faculty of Science, Department of Inorganic Chemistry, 65080 Van, Turkey.Batman University, Health Services Vocational College, 72100 Batman, Turkey.Yüzüncü Yıl University, Faculty of Science, Department of Analytical Chemistry, 65080 Van, Turkey. Electronic address: zuhresenturk@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27343573

Citation

Yiğit, Aydın, et al. "Graphene/Nafion Composite Film Modified Glassy Carbon Electrode for Simultaneous Determination of Paracetamol, Aspirin and Caffeine in Pharmaceutical Formulations." Talanta, vol. 158, 2016, pp. 21-29.
Yiğit A, Yardım Y, Çelebi M, et al. Graphene/Nafion composite film modified glassy carbon electrode for simultaneous determination of paracetamol, aspirin and caffeine in pharmaceutical formulations. Talanta. 2016;158:21-29.
Yiğit, A., Yardım, Y., Çelebi, M., Levent, A., & Şentürk, Z. (2016). Graphene/Nafion composite film modified glassy carbon electrode for simultaneous determination of paracetamol, aspirin and caffeine in pharmaceutical formulations. Talanta, 158, 21-29. https://doi.org/10.1016/j.talanta.2016.05.046
Yiğit A, et al. Graphene/Nafion Composite Film Modified Glassy Carbon Electrode for Simultaneous Determination of Paracetamol, Aspirin and Caffeine in Pharmaceutical Formulations. Talanta. 2016 Sep 1;158:21-29. PubMed PMID: 27343573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Graphene/Nafion composite film modified glassy carbon electrode for simultaneous determination of paracetamol, aspirin and caffeine in pharmaceutical formulations. AU - Yiğit,Aydın, AU - Yardım,Yavuz, AU - Çelebi,Metin, AU - Levent,Abdulkadir, AU - Şentürk,Zühre, Y1 - 2016/05/16/ PY - 2016/03/06/received PY - 2016/05/11/revised PY - 2016/05/14/accepted PY - 2016/6/26/entrez PY - 2016/6/28/pubmed PY - 2018/1/27/medline KW - Aspirin KW - Caffeine KW - Graphene-Nafion composite film modified glassy carbon electrode KW - Paracetamol KW - Pharmaceutical formulation SP - 21 EP - 29 JF - Talanta JO - Talanta VL - 158 N2 - A graphene-Nafion composite film was fabricated on the glassy carbon electrode (GR-NF/GCE), and used for simultaneous determination of paracetamol (PAR), aspirin (ASA) and caffeine (CAF). The electrochemical behaviors of PAR, ASA and CAF were investigated by cyclic voltammetry and square-wave adsorptive anodic stripping voltammetry. By using stripping one for simultaneous determination of PAR, ASA and CAF, their electrochemical oxidation peaks appeared at +0.64, 1.04 and 1.44V, and good linear current responses were obtained with the detection limits of 18ngmL(-1) (1.2×10(-9)M), 11.7ngmL(-1) (6.5×10(-8)M) and 7.3ngmL(-1) (3.8×10(-8)M), respectively. Finally, the proposed electrochemical sensor was successfully applied for quantifying PAR, ASA and CAF in commercial tablet formulations. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/27343573/Graphene/Nafion_composite_film_modified_glassy_carbon_electrode_for_simultaneous_determination_of_paracetamol_aspirin_and_caffeine_in_pharmaceutical_formulations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(16)30372-1 DB - PRIME DP - Unbound Medicine ER -