Tags

Type your tag names separated by a space and hit enter

Preparation and drug release properties of norisoboldine-loaded chitosan microspheres.
Int J Biol Macromol. 2016 Oct; 91:1101-9.IJ

Abstract

This study aimed to develop injectable norisoboldine (NOR) chitosan microspheres formulated through the emulsion cross-linking method. The formulation was optimized using response surface methodology (RSM) with a three-level, three-factor Box-Behnken design (BBD). The morphology, size, physicochemical characterization and in vitro release behavior of the optimized formulation were evaluated. Scanning electron micrographs (SEM) indicated that the microspheres were spherical with a smooth surface. The encapsulation efficiency and drug loading content of the microspheres were 38.89%±1.72% and 4.25%±0.15%, respectively, with an average size of 105μm. Fourier-transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD) revealed the absence of a drug-polymer interaction and the amorphous nature of an entrapped drug. Analysis results of drug release in vitro show the burst release of the microsphere in 2h and a slow progression afterward. In vivo studies using Sprague-Dawley rats revealed that the NOR-loaded chitosan microspheres were biocompatible. This study suggests that the BBD with desired formulation could provide a suitable drug delivery system of chitosan microspheres.

Authors+Show Affiliations

The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, China.The Third People's Hospital of Jinan, Jinan 250132, China.The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, China.The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, China.The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, China. Electronic address: xhweixh@163.com.The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201210, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27344949

Citation

He, Miao, et al. "Preparation and Drug Release Properties of Norisoboldine-loaded Chitosan Microspheres." International Journal of Biological Macromolecules, vol. 91, 2016, pp. 1101-9.
He M, Wang H, Dou W, et al. Preparation and drug release properties of norisoboldine-loaded chitosan microspheres. Int J Biol Macromol. 2016;91:1101-9.
He, M., Wang, H., Dou, W., Chou, G., Wei, X., & Wang, Z. (2016). Preparation and drug release properties of norisoboldine-loaded chitosan microspheres. International Journal of Biological Macromolecules, 91, 1101-9. https://doi.org/10.1016/j.ijbiomac.2016.06.076
He M, et al. Preparation and Drug Release Properties of Norisoboldine-loaded Chitosan Microspheres. Int J Biol Macromol. 2016;91:1101-9. PubMed PMID: 27344949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and drug release properties of norisoboldine-loaded chitosan microspheres. AU - He,Miao, AU - Wang,Haiyan, AU - Dou,Wei, AU - Chou,Guixin, AU - Wei,Xiaohui, AU - Wang,Zhengtao, Y1 - 2016/06/23/ PY - 2016/01/31/received PY - 2016/06/15/revised PY - 2016/06/23/accepted PY - 2016/6/28/entrez PY - 2016/6/28/pubmed PY - 2017/3/7/medline KW - Chitosan KW - Microsphere KW - Norisoboldine KW - Response surface methodology SP - 1101 EP - 9 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 91 N2 - This study aimed to develop injectable norisoboldine (NOR) chitosan microspheres formulated through the emulsion cross-linking method. The formulation was optimized using response surface methodology (RSM) with a three-level, three-factor Box-Behnken design (BBD). The morphology, size, physicochemical characterization and in vitro release behavior of the optimized formulation were evaluated. Scanning electron micrographs (SEM) indicated that the microspheres were spherical with a smooth surface. The encapsulation efficiency and drug loading content of the microspheres were 38.89%±1.72% and 4.25%±0.15%, respectively, with an average size of 105μm. Fourier-transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD) revealed the absence of a drug-polymer interaction and the amorphous nature of an entrapped drug. Analysis results of drug release in vitro show the burst release of the microsphere in 2h and a slow progression afterward. In vivo studies using Sprague-Dawley rats revealed that the NOR-loaded chitosan microspheres were biocompatible. This study suggests that the BBD with desired formulation could provide a suitable drug delivery system of chitosan microspheres. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/27344949/Preparation_and_drug_release_properties_of_norisoboldine_loaded_chitosan_microspheres_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(16)30622-5 DB - PRIME DP - Unbound Medicine ER -