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SARS and MERS: recent insights into emerging coronaviruses.
Nat Rev Microbiol. 2016 08; 14(8):523-34.NR

Abstract

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. The continuing introductions of MERS-CoV from dromedary camels, the subsequent travel-related viral spread, the unprecedented nosocomial outbreaks and the high case-fatality rates highlight the need for prophylactic and therapeutic measures. Scientific advancements since the 2002-2003 severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic allowed for rapid progress in our understanding of the epidemiology and pathogenesis of MERS-CoV and the development of therapeutics. In this Review, we detail our present understanding of the transmission and pathogenesis of SARS-CoV and MERS-CoV, and discuss the current state of development of measures to combat emerging coronaviruses.

Authors+Show Affiliations

Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.Vaccine and Infectious Disease Organization - International Vaccine Centre and Department of Veterinary Microbiology, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3, Canada.Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27344959

Citation

de Wit, Emmie, et al. "SARS and MERS: Recent Insights Into Emerging Coronaviruses." Nature Reviews. Microbiology, vol. 14, no. 8, 2016, pp. 523-34.
de Wit E, van Doremalen N, Falzarano D, et al. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016;14(8):523-34.
de Wit, E., van Doremalen, N., Falzarano, D., & Munster, V. J. (2016). SARS and MERS: recent insights into emerging coronaviruses. Nature Reviews. Microbiology, 14(8), 523-34. https://doi.org/10.1038/nrmicro.2016.81
de Wit E, et al. SARS and MERS: Recent Insights Into Emerging Coronaviruses. Nat Rev Microbiol. 2016;14(8):523-34. PubMed PMID: 27344959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS and MERS: recent insights into emerging coronaviruses. AU - de Wit,Emmie, AU - van Doremalen,Neeltje, AU - Falzarano,Darryl, AU - Munster,Vincent J, Y1 - 2016/06/27/ PY - 2016/6/28/entrez PY - 2016/6/28/pubmed PY - 2017/5/11/medline SP - 523 EP - 34 JF - Nature reviews. Microbiology JO - Nat Rev Microbiol VL - 14 IS - 8 N2 - The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. The continuing introductions of MERS-CoV from dromedary camels, the subsequent travel-related viral spread, the unprecedented nosocomial outbreaks and the high case-fatality rates highlight the need for prophylactic and therapeutic measures. Scientific advancements since the 2002-2003 severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic allowed for rapid progress in our understanding of the epidemiology and pathogenesis of MERS-CoV and the development of therapeutics. In this Review, we detail our present understanding of the transmission and pathogenesis of SARS-CoV and MERS-CoV, and discuss the current state of development of measures to combat emerging coronaviruses. SN - 1740-1534 UR - https://www.unboundmedicine.com/medline/citation/27344959/SARS_and_MERS:_recent_insights_into_emerging_coronaviruses_ L2 - https://doi.org/10.1038/nrmicro.2016.81 DB - PRIME DP - Unbound Medicine ER -